Triplex assay used to assay duplex genomic DNA
...m temperature. Reactions can be monitored after as little as five minutes. The highly sensitive diagnostic assay allows for the direct detection of base sequence in human genomic duplex samples, thereby obviating the use of PCR which has inherent problems and is costly. "We developed the heteropolymeric tr...Living with water scarcity -- world must act now
... are home to the highest number of poor people. A little additional water can go a long way in these areas. "Upgrading these rainfed lands through better water management holds the greatest potential to increase productivity, and decrease poverty," says Johan Rockstrom of Stockholm Environment Institute a...Tiny clue reveals new path toward heart disease
...re known to contribute to coronary artery disease, little is known about genes that render an individual susceptible to developing the disease, said study co-investigator Elizabeth R. Hauser, Ph.D., an associate professor of medicine at the Duke Center for Human Genetics. In a previous study, the researc......ot live very long. However, when flies have only a little TCTP in their cells, they are very small, said Choi. Graduate student Ya-Chieh Hsu, through a series of studies that concentrated on the effect of the protein on the eyes and wings, elucidated the role of TCTP in the cell. "She was able to show ge...Mitochondrial genes move to the nucleus -- but it's not for the sex
...he nuclear genome is recombination, after all, but little recombination takes place in self-pollinating species. So what, exactly, might be luring mitochondrial genes to the nucleus? "We're not quite sure why yet, but we've hypothesized that successful mitochondrial genes are pairing up with related nuc...Targeting tumors the natural way
...icin destroyed cells even when they expressed very little integrin, indicating this strategy has the potential to kill cancerous and healthy cells indiscriminately. "This study suggests that the cell recognition mode we used can direct an endogenous immune response to destroy cancer cells selectively," sa...In presence of fragrant cleaning products, air purifiers that emit ozone can dirty the air
...he room when a purifier was not operating produced little change in the overall particle level. The scientists also developed a mathematical model that precisely matched their experimental observations. This model can be used to predict whether a given air purifier will make the air dirtier in a given in...Morphine makes lasting -- and surprising -- change in the brain
Morphine, as little as a single dose, blocks the brain’s ability to st...that LTP is blocked in the brains of rats given as little as a single dose of morphine. The drug’s impact was powerful: LTP continued to be blocked 24 hours l...Linheng Li Lab documents the development of cancer stem cells
...planted into a secondary host. Until now, however, little was known about the process by which mutations in a stem cell result in primary tumor initiation. The Li Lab team studied the intestinal system in mice in which one of the human tumor suppressor genes, PTEN, had been deleted. They found that the...Study finds mercury prevalent in many western fish
...reshold of concern for fish-eating mammals, though little research has been done on how different levels of mercury affect mink, otter and related animals. Nevertheless, the survey found that 93 percent of the streams and rivers with large piscivores exceeded that level of mercury deemed "protective" for fi...Army research mission focused on autism
..., or even looking at us anymore; he was in his own little world. At four years old, he had no language, was not potty trained, and was smearing (feces) on the walls. My baby had been stolen away from us." This was the reality Lyn Redwood of the National Autism Association faced when her child was diagnos...Ocean's 'twilight zone' may be a key to understanding climate change
...mosphere as a green-house gas, the oceans may have little impact on changes in the atmosphere or climate. T...ep ocean and is stored there, the oceans will have little impact on climate change." Buesseler was the leader of a project funded by the National Science F...Fish growth changes enhanced by climate change
...per cent slower than in the 1860s. There was no or little change in the growth rates of species found between 500 and 1,000 metres. Growth rates of the juveniles of the deep-water species all began decreasing well before the onset of commercial fishing. Dr Thresher said slower growth in fishes has bee...Turning a cellular sentinel into a cancer killer
...plays a central role in the development of cancer, little was known about whether p53 inactivation played a role in maintaining cancers. And researchers were not sure whether switching p53 back on in tumor cells would have any therapeutic effect. "It had been demonstrated that overexpressing p53 at very h...MIT: Pulsing light silences overactive neurons
...le that is very close to what you want, and with a little bit of luck it will turn out to work," Boyden said. The halorhodopsin work is one of the first projects from the Media Lab Neuroengineering and Neuromedia Group, which was formed about six months ago to enhance the Media Lab's study of the brain-b...Minuscule molecules pack a powerful punch
...tivity was found in lymphoma development. "Very little is known about the function of the hundreds of microRNA genes," said Dr Antony Rodriguez, lead author on the paper from the Wellcome Trust Sanger Institute. "Although plentiful, this class of gene had never before been knocked out in mice, the best m......embrane. When the osteoclast is on the move, these little dots amble randomly around the cell, but when the cells prepare to dissolve the bone, they make a beeline for the edge. Scientists had been unsure how podosomes were involved in ring formation or, if they did form the ring, whether they somehow fused...Biologists call for better choice of model organisms in 'evo-devo'
...cific parts of the phylogenetic tree. "There is little point in blindly increasing the diversity of model systems, without some specific goals in mind. "Our toolkit is too narrow, so as a community we need to clarify our objectives and set the agenda for future studies."...Brain works more chaotically than previously thought
...ear. Nerve cells receive their signals by means of little "arms", known as dendrites. Dendrites pass on the electrical impulses to the cell body, or soma, where they are processed. The component responsible for "distributing" the result is the axon. Axons are long cable-like projections of the cell along wh...Cholera pathogen reveals how bacteria generate energy to live
...ands, "We are trying to kill our enemies with very little knowledge." ...