lipid 2 3

Tag: "lipid" at biology news

Measuring artery repair cells could become new heart disease test

...hey could become as routine as the cholesterol and lipid tests cardiologists now commonly use. Patients with lower levels of circulating EPCs would be less able to repair cardiac damage. Thus, they would be those with greater disease and at greater risk for a cardiac event, said the Duke cardiologists Add...

Key heart and Alzheimer's disease protein imaged for first time in native state

...roteins change their shape once they've bound to a lipid and have begun their key functions. "Until now, we...rly apoE4, has long been studied for its role as a lipid transport protein and its involvement in cardiovascular disease. Much of the pioneering work on this...

Wrinkled membranes create novel drug-delivery system

...capsules, Chaieb begins by confining a drug inside lipid bilayer membranes. Some of the lipids are then "sewn together" through a polymerization process. Cooling the capsules by 10 degrees Celsius causes the capsules to crumple and collapse like deflated beach balls, releasing the drug. "The release rate ...

'Nano-keys' bind cell receptors and trigger allergic reactions

...faces of silicon with a layer of polymer or a thin lipid (fatty molecules that make up cell membranes) bilayer. The surfaces, which are engineered on the micron scale (0.000001 meter; there are 25,400 microns in an inch), are arranged in patterns that contain antigens and cause IgE-receptors to cluster whe...

Have a taste for fat? Yes! A sensor in the mouth promotes preference for fatty foods

...ility for an additional taste modality directed to lipid has often been suggested because many animals exhi...rd and colleagues identify the first candidate for lipid detection in the oral cavity. The authors combine genetic, morphological, behavioral and physiolo...

Chlamydia parasite lives off our fat

...ent for the bacteria to grow and multiply. Because lipid acquisition from the host is necessary for chlamydial replication, these pathogens are essentially lipid parasites. So, to add insult to injury, Chlamydia apparently lives on our fat. Lipid droplets are ...

Common alternative treatment for liver disease is found to be ineffective

... various hepatotoxins, including the prevention of lipid perioxidation, which is frequent in all stages of liver damage in alcoholic and non-alcoholic liver disease. "The ironic fact is," notes Christian Gluud of the Copenhagen Trial Unit, Center for Clinical Intervention Research at the Copenhagen Univer...

Life in deadly conditions

... particularly large number of proteins attached to lipid molecules, anchoring it to the cell membrane. Important functions of the energy metabolism - for example, the respiratory chain - are embedded in the cell membrane and have to be adapted to the adverse external conditions. Despite a detailed bioinfo...

Baby's genes affect mom's cholesterol levels

...study focused on two specific proteins involved in lipid metabolism, lipoprotein lipase and apolipoprotein E. "Apolipoprotein E and lipoprotein lipase play important roles in the degradation of triglyceride-rich lipoproteins," notes Descamps. "In pregnant women, the concentrations of these lipoproteins are...

Newly recognized gene mutation may reduce seeds, resurrect plants

...ed a previously unknown genetic connection between lipid development and embryo development in plants, said...ling and in energy storage. A still-to-be revealed lipid associated with formation of the cuticle that coats plant surfaces may signal whether a seed develop...

'Cookbook recipes' would cure disease with nontoxic DNA delivery systems

...en becomes: 'How do you stick a negatively charged lipid to a negatively charged DNA molecule?'" said Wong, who also is a researcher at the Beckman Institute for Advanced Science and Technology. "One idea is to glue the lipids and DNA together with positively charged ions like calcium." Using synchrotron ...

Weight control protein may yield antiobesity drugs

... The mice also exhibited a near doubling of blood lipid levels and their livers grew to more than twice their normal size owing to a massive accumulation of fat, Rui said. Moreover, the animals developed severely elevated blood sugar, insulin, and leptin concentrations. Elevated leptin levels are a hallm...

VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells

... SphK2 - a family of enzymes that forms the potent lipid mediator, sphingosine-1-phosphate, and that breast...tionally recognized for her pioneering work on new lipid mediators that regulate cell growth and cell death, and her colleagues, first discovered the role of...

Beyond genes: Lipid helps cell wall protein fold into proper shape

...how it folds so that it can function properly. Its lipid environment also plays a role," Dowhan said. "Peop...ein interacts with the lipid, and what part of the lipid with the protein?" said Dowhan, who holds the John S. Dunn Sr. Chair in Biochemistry and Molecular B...

Study casts doubt on 'Snowball Earth' theory

...hale deposits from southeastern Brazil and applied lipid biomarker techniques to identify prehistoric organisms based on the fatty remains of their cell membranes. The team, which included scientists from USC, Caltech, the University of Maryland and a Brazilian mining company, identified "a complex and pr...

Study shows how retinoic acid enters a cell's nucleus

...member of a group of proteins called intracellular lipid binding proteins (ILBP), which don't have a recognizable NLS. But now researchers have something new to look for -- folds in a molecule's structure and amino acids that flip when exposed to a hormone or a drug. Noy currently is working with an ILBP t...

Scripps research scientists identify infertility molecule

...rch Center. "[These results] offer new insights on lipid signals and fertility." If the receptors do turn out to be relevant to embryo implantation in humans, then the mechanisms involving these proteins might make good targets for therapeutic intervention, perhaps even leading to new treatments and succe...

Excess liver gene protects against high-fat diet

...balanced diet, the excess receptors worsened blood lipid levels, the researchers reported. The findings su... LXRa activity may have potential as therapies for lipid disorders and atherosclerosis, the group said. "The high-cholesterol, high-fat Western diet has abe...

New understanding of cell movement may yield ways to brake cancer's spread

...ey signaling protein that binds to PIP3. PIP3 is a lipid that accumulates on the leading edge of a cell abo...one end of the cell to the other. It is this PIP3 lipid gradient that sets the cell into motion toward the right direction. The PIP3-binding portion of DOCK...

Lipids get new comprehensive classification system

...sive amounts of data that will be generated by the lipid community, an international group of scientists ha...p bioinformatics approaches that establish dynamic lipid networks. In order to coordinate their efforts with those of other groups, such as the Lipid Bank in...

1 2 3 4