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Tag: "lipid" at biology news

Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily

...arger protein) affected the energy of manufactured lipid bilayers made to mimic normal cell membranes. Lipi...tists used X-rays to detect the effect of FP-23 on lipid bilayers that mimic cell membranes. Lipid bilayers form different phases that change with temperatur...

In mice, drug protects against diabetes and atherosclerosis

... mice and humans carrying the gene variant. The lipid chaperone protein aP2 acts as a signal in cells, s... and trigger a heart attack. In mice lacking these lipid chaperones, there was no sign of heart disease. Next, the researchers turned to humans. While the...

Could fungal collection hold the key to new life-saving drugs?

...uppressive agents, antibiotics such as penicillin, lipid lowering agents and anti-fungal drugs....

New designer lipid-like peptide with lipid nanostructures for drug delivery systems

...c science of how lipid-like peptides interact with lipid molecules, but also may provide new strategies for...ater. “This is a systematic study to combine with lipid molecules,” Shuguang Zhang of MIT, a co-author said, “people have been curious about if these simila...

Hawaiian treasure, macadamia nuts good for the heart

... levels, normal blood pressure and were not taking lipid lowering drugs. Researchers randomly assigned participants to either the macadamia nut diet or the standard American diet and provided all meals for the participants for five weeks. The participants then switched diets and continued eating only food ...

Keeping the immune system from starting a 'food fight'

...istance, glucose intolerance, high blood sugar and lipid levels, and fatty liver disease. They also showed that the loss of STAMP2 exacerbated the metabolic symptoms of mice with a genetic predisposition to obesity due to other factors. When food enters the system, STAMP2 normally keeps the immunity res...

Chemical maps hint at drug's effects on schizophrenia

...alizes in diagnostic discovery with an emphasis on lipid metabolism. Atypical antipsychotics, a newer group... and communicating information in the brain. These lipid changes were partially reversed in patients treated with antipsychotic medications, said Joseph McEv...

Fat overrides effects of vitamin C

...niversity of Glasgow found that in the presence of lipid the ability of antioxidants, such as ascorbic acid (the active component of vitamin C), to protect against the generation of potential cancer-forming compounds in the stomach is less than when no lipids are present. “Our results illustrate how diet c...

Bacterial walls come tumbling down

... plucking sugars from a fat-sugar package known as lipid II. The antibiotic, which is another kind of sugar-lipid, probably mimics the lipid II molecule by tucking into a fold in the enzyme and taking up the space needed to bind to lipid II,...

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease

...rain's supply of the enzyme Hex, which reduced the lipid accumulations in the treated animals. The experimental treatment also dampened the inflammation that typically occurs in the brains of most degenerative diseases, including Sandhoff's, and likely contributes to disease progression. "Ou...

Link found between immune system and high plasma lipid levels

...ted link between the immune system and high plasma lipid levels (cholesterol and triglycerides in the blood...uce the risk of heart disease by lowering elevated lipid levels. In the April 13, 2007, issue of Science, the research team—led by James C. Lo, an MD, PhD...

Instruction manual for creating a molecular nose

...hesized membrane proteins directly into artificial lipid membranes (Angewandte Chemie, International Editio...ing the developing membrane proteins to artificial lipid membrane systems that mimic natural cell membranes from a statu nascendi, and the membrane proteins ...

Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment

...nction. To make matters worse, the products of the lipid breakdown are also known to trigger inflammation and cell death. Together, these facts compellingly suggest that SMase plays a critical role in the heretofore mysterious pathogenesis of lung injury in CF patients. They also present a new paradigm...

Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer

...cancer patients via an intravenously administered lipid nanoparticle in a phase I clinical trial at The University of Texas M. D. Anderson Cancer Center. The gene, FUS1, also was found to be active in the metastatic non-small cell lung cancer tumors. "We've treated 13 patients in this first-in-human st...

Tears reveal some of their deepest secrets to researchers

...pectrometry to differentiate between the different lipid components. This technique adds an electric charge...ctrometry is sensitive enough to detect individual lipid molecules, like oleamide," Nichols said. Oleamide was first identified as a lipid in the brain, w...

Researchers show that veins stiffen as we age

...screening at Christiana Hospital, which included a lipid profile, blood pressure monitoring, electrocardiogram and several other tests to ensure overall good health. Then each participant was involved in a series of research trials at UD's Human Performance Lab on the Newark campus. While each subject la...

New study finds chocolate chip cookies lower cholesterol

...ate Chip Cookies TM lower cholesterol and improve lipid subfraction profile, lowering the risk of heart disease, according to a published study in The Journal of Nutrition (October). The chocolate chip cookies, made with a combination of psyllium and plant sterols, are a tasty all-natural approach to red...

How mammals fuel milk production may have implications for cancer

...on, a mouse will produce its entire body weight in lipid as well as three times its total body weight in mi... Akt1 in the mammary glands of mice leads to early lipid accumulation during pregnancy, raising the possibility that the gene might be important in the incre...

Researchers to develop active nanoscale surfaces for biological separations

... closely coupled to the movement of the underlying lipid bilayer. "The advantage of these surfaces is th... molecules of all types move across the surface of lipid bilayers. "This particular project is focused on DNA, but the approach could potentially be used for...

Sandia researchers discover way to see how a drug attaches to a cell

... used as a blueprint consists of a double layer of lipid (detergent) molecules. The liposomes are placed in... in the narrow space between the two layers of the lipid transfer electrons to the platinum ions. The uncharged platinum atoms gather into tiny metal clumps....

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