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Probing the promise and perils of nanoparticles

...o deliver drugs and genes---to see if they behaved like dendrimers. "It turns out that they cause the same permeability and, in general, they cause membrane destruction as well," said Banaszak Holl. Neutral polymers, however, did not damage membranes. Both Leroueil's work and the earlier research used mo...

Not-for-profit publishers call NIH public access rule a missed opportunity

...f NIH created an enhanced search engine that works like Google to crawl the journals' full text articles and link to the final published articles residing on the journal websites. This would offer significantly more assistance to those seeking medical research results than a database of NIH-funded manuscr...

Researchers devise way to mass-produce embryonic stem cells

...of millions more stem cells. Mass-producing cells like this could reduce stem cell production costs by at...uld not. "Cells grown on a flat surface don't act like they would in the body," Yang said. "The growing surface affects how a cell forms, what it looks lik...

Chemists identify immune system mechanism for methamphetamine binges

...small drug molecules," Janda says. "Glycation acts like a linker that allows [the methamphetamine] to be d...ome of it is bound up by antibodies and "soaked up like a sponge," according to the researcher. "If the mechanism we proposed proves true in humans, then i...

Great White shark evolution debate involves WSU Lake Campus geology professor

...cination with sharks. "The general public seems to like sharks, and maybe this is because they bring out t...rge scale changes of life over time and how things like mass extinction affect the course of life," he said. Ciampaglio discussed his shark research findin...

Viral protein influences key cell-signaling pathway

...ed women to children through breast milk. HTLV-1, like its cousin HIV, inserts its genetic information permanently into the DNA of a T lymphocyte and remains there for the life of the cell. HTLV-1 infection is also lifelong. A hallmark of HTLV-1 infection is the proliferation of T lymphocytes. This sets...

Flocking together: Study shows how animal groups find their way

...dividuals to form close-knit, evenly spaced groups like those of real animals, which pay a high price -- such as being eaten -- if they stray from their group. Second, a few animals were programmed to have a preferred direction, as if aware of a food source or other valued destination. These animals were...

Liposome finding implies electrical effect on cell development

... process involved in the development of structures like axons and dendrites in nerve cells. Hayes will pr...ely form and extend from the phospholipid balloon, like a seed putting forth a stalk or root. Hayes believes that the phenomena may have significant implic...

Controlling protein diversity

.... In other words, if the information in a gene is like the elements of a computer code, leaving out some ...agues have shown in previous studies that hormones like estrogen and progesterone can change the amounts of proteins made by their target genes. When hormon...

Robot-based system developed at Carnegie Mellon detects life in Chile's Atacama desert

...e detection system worked very well, and something like it ultimately may enable robots to look for life on Mars," said Alan Waggoner, Atacama team member and director of the Molecular Biosensor and Imaging Center at the university's Mellon College of Science. The "Life in the Atacama" 2004 field season ...

Alaskan puzzles, monitoring provide insight about North Pacific salmon runs

...c and fishery sciences. "The Kvichak sounds a lot like Columbia River or Puget Sound stocks," he says. Still, 20 miles away from the Kvichak are similar lakes and rivers with record production. "Our research is directed toward understanding why these runs see such different trends, by looking broadly a...

Nanoscale Diagnostic Sets Sights on Alzheimer's

...eases. This is particularly important for diseases like Alzheimer's where a reliable diagnostic tool is lacking and early intervention could have a significant impact on the lives of patients and their loved ones, in addition to lowering health care costs." ?Sohi Rastegar ...

Transgenic plants remove more selenium from polluted soil than wild plants, new tests show

...said Terry. "So what we want to do is take a plant like Indian mustard, because it can grow quickly -- up ... are heading in the right direction." Researchers like using the Indian mustard plant because it is very efficient at absorbing selenate, the bioavailable ...

50-year-old Mystery Solved: Protein Tags Regulate Key Ion Channel

... to reveal their function because they were silent like K2P1." Other membrane proteins key to biology, like transporters and hormone receptors, may also be controlled by SUMO since the binding site is present...

Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection

... infection gap between previously separate animals like humans and elk and deer, which suffer from a prion disease called chronic wasting disease. Surewicz stresses, however, prion infection between species is still rare. "Fortunately, transmission by eating is very ineffective. There have been hundreds ...

Scientists discover how plants disarm the toxic effects of excessive sunlight

...tic bacteria, including human and animal pathogens like Vibrio and Pseudomonads have systems to sense and protect themselves from singlet oxygen, says Donohue. Other reactive oxygen species - often called "free radicals" - are thought to be at the root of many debilitating diseases. "There have been cons...

Gene Therapy Cures Inherited Liver Disease In Rats

... viral vector is fairly benign long term, he would like to see one developed that minimizes the body's immune response to it immediately right after it is injected into the body. "Fifteen years ago, the goal was to get some correction of the problem," he said. "Most effects were transient. Now with these...

Multi-purpose protein regulates new protein synthesis and immune cell development

...ntervention for B cell-driven autoimmune diseases, like myasthenia gravis or systemic lupus erythematosus....ent, which could be helpful in autoimmune diseases like diabetes and lupus." ...

Gene therapy promising for growing tooth-supporting bone

... Giannobile added. He said he optimistically would like to see initial trials begin in humans in four to seven years. BMP-7 is part of a family of proteins that regulates cartilage and bone formation. Recent studies have shown that BMPs are present in tooth development and periodontal repair. This study...

Affymetrix Licenses Microfluidics Technology From Caliper Life Sciences

...e are pleased that a leading life sciences company like Affymetrix recognizes the vast potential of LabChip technologies," said Kevin Hrusovsky, President and CEO at Caliper. "Affymetrix is moving beyond basic research applications and is pioneering areas such as pharmacogenomics and personalized medicine...

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