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Chemists create 'Superbowl' molecule; May lead to better health

...e Journal of the American Chemical Society. Shaped like a miniature football stadium, the molecule is capa...de and one on the bottom. It has an open top, much like an open-air stadium. Its general molecular formula is C268H320O52. The tiny molecules can be modifie...

DNA Molecules Used To Assemble Nanoparticles

...erent combinations with the DNA strands. "So it's like having a shelf full of Tinker Toys," Baker said. An array of single-functional dendrimers, such as targets, drugs, and contrast agents, and the ability to link them together quickly and easily in many different ways would enable a clinic to offer 25...

Bioartificial kidney under study at MCG

... the body. The stuff that isn't pumped out is just like urine: it goes in the toilet," Dr. Szerlip says. Preliminary findings on 10 patients at the University of Michigan Medical Center and Cleveland Clinic Foundation showed the device was safe and produced desired results such as reducing circulating in...

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...o turn genes on and off and adjust their activity, like a dimmer switch that varies the brightness of a light. Co-activators join with other regulatory proteins called transcription factors in controlling the expression of genes. Spiegelman and Jiandie Lin, PhD, the paper's lead author and a researcher at...

Spleen may be source of versatile stem cells

...protein has an intriguing function: when creatures like newtsregenerate a lost limb or tail, production of...payback that can come fromstudies of lower animals like newts and sponges. Combining theknowledge of Hox11's role in those animals with what we'd found abou...

UAB scientists discover the origin of a mysterious physical force

... small electric fields, such as chemical compounds like those found in many detergents, this is no longer the case: the water molecules have a remarkable capacity to organise themselves into complex structures that are strongly orientated in such a way as to cancel out the electric field, and on some occa...

Source of molecular triggers in cutaneous T cell lymphoma identified

...years ago. The Yale research group reported that, like all T cells, the cancerous CTCL cells require antigenic stimuli delivered by specialized dendritic cells of the epidermis, referred to as Langerhans cells (LC), in order to replicate. To determine the nature of the activating antigen, Carole Berger,...

Protein discovery could unlock the secret to better TB treatment

..., the disease becomes treatable using common drugs like antibiotics. Scientists believe that uncovering the molecular structure of this protein will lead the way to designing drugs which enable treatment of dormant and multidrug resistant TB. In England and Wales around 400 people die each year from the ...

Yellowstone microbes fueled by hydrogen, according to U. of Colorado study

...wingthe microbes to accumulate. "Bacteria are just like us. They like to betogether, they like to be attached to a surface and they like to havetheir food - dissolved hyd...

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...tsushi Kaneda, Ph.D. "Double the risk may not seem like much, but this loss of imprinting is common." The researchers' mice mirror two situations in people because the double dose of IGF2 was accomplished in two ways. One set of mice, obtained from Shirley Tilghman at Princeton, have a double dose of IGF...

Growth in the sea comes down to a struggle for iron

.... "The North Atlantic has a big spring bloom, just like we have on our coast, but these other areas have a...s very well. The idea is that it (the molecule) is like a magic bullet. They release it, it binds iron, and then only they have the key to unlock it and get...

New, automated tool successfully classifies and relates proteins in unprecedented way

...ting thisinformation is critical to foil a disease like cancer, where you mightwant to identify and disable part of a tumor cell's machinery needed toprocess proteins for cancer growth."Our tool represents a step forward because it is based on standardizedfeatures and not on features chosen by the human e...

Neuronal 'traffic jam' marks early Alzheimer's disease

...croscopy and biochemical markers, they looked just like the axonal transport blockages we saw in fruit flies." Detailed studies of the neurons revealed what Goldstein termed a "traffic jam" of transport-related proteins, organelles and sac-like vesicles that are the cargo-carriers for cellular proteins. ...

Mouse brain cells rapidly recover after Alzheimer's plaques are cleared

...theirAlzheimer's-like condition."For example, we'd like to know what's going wrong in the nerve cellbranches that get these swellings," Holtzman says. "Is it really acellular transport problem, or do the swellings result from theplaques' effects on nearby support cells? Or is it something else?"...

Key molecule in plant photo-protection identified

...theirAlzheimer's-like condition."For example, we'd like to know what's going wrong in the nerve cellbranches that get these swellings," Holtzman says. "Is it really acellular transport problem, or do the swellings result from theplaques' effects on nearby support cells? Or is it something else?"...

Antarctic ice shelf retreats happened before

...e of recent dramatic disintegration of ice shelves like Larsen B, the new study suggests that the ocean may play a more significant role in destroying them than previously thought. The University of Durham's, Dr Mike Bentley, one of the leaders of the project said, 'We know that rising air temperatures c...

Newly-discovered class of genes determines ?and restricts ?stem cell fate

...kin could be the cells that turn into skin cancers like melanoma. Understanding stem cell biology may therefore be important for developing new therapies for cancer. Adult resident stem cells have been identified in many types of organs and may be a potential reservoir for tissue regeneration. A fundamen...

Tiny particles could solve billion-dollar problem

...ast, breaking down TCE with more common catalysts, like iron, produces intermediate chemicals, like vinyl chloride, that are more toxic than TCE. In the CBEN experiments, Wong and collaborators compa...

Plants, animals share molecular growth mechanisms

...ent in the middle that is specific to plants. We'd like to know if this section is important and whether it regulates DIS3 or the whole WAVE complex." For growth and development biochemical processes to proceed normally, activators such as ARP 2/3 are needed to trigger actin filaments' formation and grow...

Researchers Uncover Key Step In Manufacture of Memory Protein

...to form long-term memory. Dr. Loh explained that, like other proteins, proBDNF is made inside the endoplasmic reticulum, a convoluted network of tubes and channels inside the cell. The proBDNF winds through the endoplasmic reticulum until it reaches another structure within the cell, the golgi apparatus....

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