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Tag: "library" at biology news

New study to explore cellular circuitry

...t four years, medical center researchers created a library of 6000 clones, or exact copies of the genes of th...h a "tag" attached. One common application of the library is to separate the tagged proteins from all others in the cell, and then use the collection of tagge...

New plant DNA libraries provides massive boost to world's plant researchers

...a far wider range than is available from other DNA library services. Secondly, the Warwick researchers have b...used in the treatment of a number of cancers. The library also includes: Apple, Banana, Foxglove, Mint, Olive, Orange, Pineapple, Evening Primrose, Strawberry...

U-M researchers identify new blood test for prostate cancer

...ancer. They began by testing the samples against a library of 2,300 bacteriophage, organisms that express proteins on their surface, and were able to narrow the field to the 22 biomarkers that most often pinpointed the cancerous blood samples. More than 230,000 men will be diagnosed with prostate cancer th...

Hunt for human genes involved in cell division under way

...NAs, Ambion Europe, Ltd., to produce a genome-wide library for this project," says Dr. Jan Ellenberg, EMBL Gr...gene. EMBL chose Ambion as a supplier of the siRNA library because its library could be tailored to the most up-to-date list of human target genes ?a list prov...

UIC developing drug for SARS

...in the space. If the fit is poor, he can explore a library of alternative molecules that might meet the chemical and configurational requirements. Ghosh will then assemble the molecules that appear to work, as if the chemicals were the sticks and spools of a Tinkertoy, to create a potential drug. Crucial t...

NIH renews network focused on how genes influence drug responses

...ine resource, which serves as a shared information library for pharmacogenetics research. To protect the privacy of research study participants, names and other identifying information are not stored in this knowledge base. (Russ B. Altman, M.D., Ph.D., Stanford University School of Medicine) Pharm...

Fragment of yellow fever virus may hold key to safer vaccine

... molecular techniques, the researchers generated a library of the millions of specialized antibodies that made up their immune repertoires. Then they screened the libraries with a vaccine strain of yellow fever. Four of the antibodies neutralized yellow fever. Genetic analysis showed they all homed in on on...

Harmless virus may hold key to more effective HIV drug discovery

... study, Weiss and Olszewski first created one such library by attaching the Nef protein onto the bacteriophag...ibrary, which they call an allelome, with a second library of small-molecule compounds in order to identify the specific compounds that could target the entire...

Scientists at Galileo Pharmaceuticals confirm inflammatory response linked to glucose levels

...hosphorylated by the enzyme. They then performed a library search of small molecules (58,000 of them) in an attempt to find those that would prevent phosphorylation. Small molecules are preferred because they are more easily used as a drug since they can get through the body and into cells. It is also import...

Scientists discover that three molecules may be developed into new Alzheimer's drugs

...hosphorylated by the enzyme. They then performed a library search of small molecules (58,000 of them) in an attempt to find those that would prevent phosphorylation. Small molecules are preferred because they are more easily used as a drug since they can get through the body and into cells. It is also import...

New Look at DNA Hints at Origin of UV Damage

...ethal infection." The researchers then screened a library of almost 1,000 Y. pestis mutants and found that six virulence factors are crucial for the bacterium to have full virulence. Of the six virulence factors, three are also required for infections in mammals. One of these factors is similar to an export...

Novel plague virulence factor identified

...ethal infection." The researchers then screened a library of almost 1,000 Y. pestis mutants and found that six virulence factors are crucial for the bacterium to have full virulence. Of the six virulence factors, three are also required for infections in mammals. One of these factors is similar to an export...

Researcher gets NSF grant to create mutant maize lines

... the only resource of its kind, a sequence-indexed library that allows researchers to do a database search for a DNA sequence and identify a single line of maize with a single disruption in the genome," says Brutnell, who notes that the project could expand the understanding of the functions of about 20 perc...

Achilles heel of the herpes virus possibly found

...on by human herpes virus. They searched the genome library to find genes essential to HSV infection, isolated... research team members in working with the genomic library and culture of human and pig cells, especially U-M doctorate graduate Aleida Perez and postdoctoral ...

Using nanoparticles, in vivo gene therapy activates brain stem cells

...of which allow for the development of an extensive library of tailored nanoparticles to target gene therapies for different tissues and cell types. A key advantage of the UB team's nanoparticle is its surface functionality, which allows it to be targeted to specific cells, explained Dhruba J. Bharali, Ph.D....

Unique library of plant genes germinates, takes root at UNC

...ay, its developers say. Named Phytome, the unique library is a compilation of voluminous genetic data on 39 ...y; Dihui Lu, a graduate student in information and library science; and computer programmer Jason Phillips. The National Science Foundation is supporting the ...

Scientists identify genes responsible for 'black rot' disease in vegetables

...then screened an Xcc transposon insertional mutant library in its host plant (cabbage). They screened a total of 16,512 Xcc mutants on individual cabbage plants and, of these, 172 proved to be non-pathogenic. Upon further characterization of the 172 non-pathogenic mutants, the researchers came up with a non-...

Researchers discover chemical compounds that affect plant growth

...known as gravitropism. The researchers screened a library of 10,000 small molecules, the practice is known as chemical genomics, to identify those that could positively or negatively affect gravity's effect on plant growth, which is closely linked to the movement of proteins through plant cell membranes, a ...

Newly Discovered Compound Blocks Known Cancer-Causing Protein

... Small Molecule Screening Facility, which houses a library of more than 13,000 compounds available for screening promising drugs with potential to fight cancer and other diseases. Using automated robotics, the facility provides the kind of drug discovery capability usually available only to pharmaceutical co...

PANTHER Protein Classification System Database 5.0

...la genes. ThePANTHER system database consists of a library of 6,683 proteinfamilies, divided into 31,750 functional subfamilies, and coveringapproximately 90% of mammalian protein coding genes. The Web-basedinterface allows life scientists to browse or analyze large sets ofgenes by their known or inferred bi...

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