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Tag: "libraries" at biology news

Exploring the dark matter of the genome

...elniker says, "We grind up whole flies and produce libraries of DNA fragments of two sizes, some that are 2 kilobases long" -- a kilobase (Kb) is 1,000 bases -- "and some that are 10 kilobases long. Contiguous lengths of sequence are assembled by matching overlaps of these fragments. With euchromatin, large, s...

Technique monitors thousands of molecules simultaneously

...edical researchers make molecules, build molecular libraries and understand the mechanisms by which molecules bind to receptor sites. "We believe we can move most of modern synthetic organic chemistry to this electrochemically addressable chip. In this way, a wide variety of molecules can be generated and th...

Bacteria in small sea life yield new way to make potential cancer drugs

... the way to the genetic creation of large chemical libraries for testing against human diseases. "This proves the concept works," Schmidt said. "We can extract bacteria from animals, take DNA from the bacteria, and produce compounds." Now that they've shown compounds can be synthesized from DNA, the rese...

Genetic study of Neanderthal DNA reveals early split between humans and Neanderthals

... create a library of Neanderthal DNA. Unlike the libraries used to sequence the human genome, which contained only human DNA fragments, the Neanderthal DNA library is riddled with contamination from microbes that lived off the nutrients in the Neanderthal remains, as well as contamination from humans handlin...

Nerve cell software keeps track of brain change

...aging team who built on mathematical software code libraries from many years of image analysis research and added a user-friendly, database-supported interface. "We're working with a leading Australian brain research institute to thoroughly validate HCA-Vision. The results will be reported in scientific jour...

Gut reaction: Researchers define the colon's genome

...ar prior to the study. The researchers created DNA libraries based on the samples, generating a total of 65,059 and 74,462 sequence reads, respectively, from the two subjects. They found evidence for several hundred bacterial phylotypes, most falling into two divisions of bacteria known as Firmicutes and Actin...

New RNAi tools enable systematic studies of gene function

...anies with the mission to build comprehensive RNAi libraries and make them available to scientists worldwide. "Switching off a single gene through RNAi reveals how that gene functions in a particular biological process. When RNAi's potential is applied to thousands of genes ?as it has been in fruit flies and ...

UT Southwestern researchers develop screening test for cells that activate immune system

...immuno-stimulatory drugs by screening high-quality libraries of compounds. Doing so may be the first step toward developing a new class of vaccines that force or trick the natural immune system to kick on, or initiate an immune response that can be copied and initiated artificially. Other UT Southwestern r...

New plant DNA libraries provides massive boost to world's plant researchers

...Warwick HRI have created an extensive new range of libraries of plant DNA that will provide a massive boost to ...rld's plant researchers. The new collection of DNA libraries is the largest of its type in the world and will provide researchers with a unique resource. The Wa...

‘Blue Brain?project explores thought at molecular level

... of Health. In addition to the genome survey, 100 libraries of expressed sequences from different pig tissues and developmental stages have been analyzed. These sequences will be released in the near future together with a publication on pig gene expression. This far, the pig sequence data have been obtained...

Public release of pig genomic sequences

... of Health. In addition to the genome survey, 100 libraries of expressed sequences from different pig tissues and developmental stages have been analyzed. These sequences will be released in the near future together with a publication on pig gene expression. This far, the pig sequence data have been obtained...

Hunt for human genes involved in cell division under way

...Check bioinformatics partner. Also, Ambion's siRNA libraries utilize a siRNA design algorithm developed by Cenix BioScience GmbH (an EMBL spin-off company), leading to high efficacy of the siRNAs. "We are happy to work with Ambion and Cenix BioScience on this ambitious project. This represents the first use o...

Molecular miners find pain relief drugs from the sea

... a single cone snail we can create and store large libraries of conotoxin genes." It was using this genetic mining technique that ACV1 was discovered ?its peptide sequence was predicted solely from the DNA sequence. The peptide was then chemically synthesised in large quantities suitable for biological testin...

NIH creates nationwide network of molecular libraries screening centers

...les have been found serendipitously. The molecular libraries screening program is an effort by NIH to take an efficient, high-throughput approach toward the discovery of many more useful compounds. The Molecular Libraries Screening Centers Network is being developed through the NIH Roadmap for medical researc...

Fragment of yellow fever virus may hold key to safer vaccine

... their immune repertoires. Then they screened the libraries with a vaccine strain of yellow fever. Four of the antibodies neutralized yellow fever. Genetic analysis showed they all homed in on one particular part of the protein coating the virus. The epitope is called E-71, signifying its address on the envel...

Harmless virus may hold key to more effective HIV drug discovery

...Weiss laboratory specializes in developing massive libraries of proteins that can potentially target and bind to other proteins, using a process called phage display. In this study, Weiss and Olszewski first created one such library by attaching the Nef protein onto the bacteriophage, which was then coaxed int...

Gov't Creates Gene Database of Normal Human Tissues

...detectors built into two chips using verified cDNA libraries upon which many other researchers currently rely. Analyzing the organ tissue with this tool allowed Khan and his team to identify 18,927 genes that constitute their database. "We found that each organ had a unique expression level profile," said Khan...

Signs of aging: Scientists evaluate genes associated with longevity

...prepared SAGE (serial analysis of gene expression) libraries from roundworms that contained a mutated form of t...ed genes, the researchers compared gene-expression libraries obtained from daf-2 mutants to those obtained from controls at different ages. They predicted that g...

Researchers discover chemical compounds that affect plant growth

... a chemical, which can be found by screening large libraries for compounds that specifically affect a measurable process." The scientists found 219 chemicals that affected the direction of plant growth due to gravity. Further screens reduced this number to 34, then down to 4 chemicals, which affected gravitro...

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