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Molecular biology fills gaps in knowledge of bat evolution

...overage of classifications of bats from the family level to the genus level and probe in more detail into the bat evolutionary record. He also plans to compare the completeness...

A new mechanism of regulating RNA degradation

...icer). And now it seems that regulation at the RNA level is even more complex than we first imaginated... ...would allow the cell to differentially control the level of SMD-target RNAs, while leaving the NMD-regulated RNAs untouched. This is likely to be the "tip o...

FDA Approves Human Hookworm Vaccine for Phase I Safety Trials

...icer). And now it seems that regulation at the RNA level is even more complex than we first imaginated... ...would allow the cell to differentially control the level of SMD-target RNAs, while leaving the NMD-regulated RNAs untouched. This is likely to be the "tip o...

UAB scientists discover the origin of a mysterious physical force

...he direction the wind is blowing, at a microscopic level water molecules are gently attracted towards the direction in which an electric field is pointing. However, when the water is in contact with surfaces that create small electric fields, such as chemical compounds like those found in many detergents, ...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

...n stayed about the same, regardless of the glucose level in the bloodstream. "That surprised us," Dr. Patti said. "The problem was not insulin resistance. It had something to do with insulin secretion." By contrast, babies who are born overweight (greater than 8 pounds) have higher risk of insulin resistan...

Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs

...e salt water) three times a week for twoweeks. The level of EPCs in the volunteers' blood will be measuredb...ered experimental,however, for use to increase the level of EPCs in patients withperipheral vascular disease.The investigators are seeking patients in whom p...

Controversial drug shown to act on brain protein to cut alcohol use

...y have determined that it does so byincreasing the level of a brain protein known as glial cellline-derived neurotrophic factor, or GDNF. In a separate study, theydemonstrated that GDNF by itself decreases alcohol consumption.The research is being published in the January 19 issue of The Journalof Neurosci...

Neuronal 'traffic jam' marks early Alzheimer's disease

...rting proteins. "We made a modest reduction in the level of a motor protein called kinesin-1 in the mice, and we got a considerable increase in plaque production and plaque deposition," said Goldstein. "This makes it clear there is some mechanistic connection between the transport deficit and plaque deposi...

Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer

... uses to damage human cells and cause disease, the level of certain bacteria in the colon can be an important determinant of the amoeba's virulence. Biomedical scientists say the E. histolytica sequence will help researchers develop new tools to predict which of the millions of people who ingest amoeba cy...

Timing is everything: First step in protein building revealed

...ilar. "Theidea is to really know at the molecular level how life is puttogether," says Jon Lorsch, Ph.D., professor of biophysics andbiophysical chemistry, one of the departments in Johns Hopkins'Institute for Basic Biomedical Sciences. "We see disease largely as anincorrect timing event -- the wrong thin...

Research advances quest for HIV-1 vaccine

...g broadly neutralizing antibodies at the molecular level and transferring this knowledge into the design of vaccines capable of stimulating broadly neutralizing antibodies against globally diverse HIV. According to Dr. Wayne Koff, IAVI Sr. VP for Vaccine Research, "Elucidation of the critical features of 4...

Research on Worms Yields Clues on Aging

...mone. "Sensory inputs fromthe outside regulate the level of insulin signaling inside the body,which then in turn regulates longevity in the worms," Kornfeld says.Testing the anticonvulsants on longer-lived mutant worms, theresearchers found the drugs further extended their lives, although notto the same de...

The transparent organism: EMBLEM and Carl Zeiss give labs a unique look at life

...nner workings of living organisms at a much higher level of detail than ever before. One innovation of SPIM is the illumination of a sample from the side rather than along the traditional view of the microscope lens. This eliminates a problem that has plagued three-dimensional microscopy in the past: rese...

Iron Deficiency Sparks Dramatic Changes In Gene Expression

...specific diagnosticmarkers that would indicate his level of iron deprivation, he said.With diagnostic markers in place, physicians could translate theseverity of the disease into the appropriate treatment....

Improved Outcomes Releases GeneLinker(TM) Gold and Platinum Version 4.6

... Bytes Software Inc.).GeneLinker Gold is the entry level product that is well suited toresearchers just entering the area of genomics or proteomics research,while GeneLinker Platinum offers powerful feature detection, committeesof neural networks, committees of SVMs and committees of Bayesianclassifiers th...

The secret lives of whales

...ast one ?which is us,?says Palumbi. “Ice ages, sea level change and even loss of local food sources did not interrupt their lives. Living in a fluid environment they could move to new areas of productivity and find food even as the climate around them changed.?/p> Palumbi compares the ability to read g...

Researchers reveal the infectious impact of salmon farms on wild salmon

...bate about sea lice is that there hasn't been this level of precision in the sampling and modeling," says coauthor Mark Lewis, a mathematical ecologist from the University of Alberta known for his work on West Nile virus and invasive species. "We have worked out the spatial footprint ?the data are strong a...

Clam embryo study shows pollutant mixture adversely affects nerve cell development

...ng the origins of BCE toxicity atthe single-neuron level to learn what genes are turned on and off bythe exposure to the chemical mixture. The research is focused on afamily of genes known as P53, which helps to regulate the cell cycle.They have also moved their studies to a new model system: thezebrafish,...

Study identifies predictors of HIV drug resistance in patients beginning triple therapy

...ng the origins of BCE toxicity atthe single-neuron level to learn what genes are turned on and off bythe exposure to the chemical mixture. The research is focused on afamily of genes known as P53, which helps to regulate the cell cycle.They have also moved their studies to a new model system: thezebrafish,...

ASU researchers finds novel chemistry at work to provide parrot's vibrant red colors

...d the colors of parrots, describing on a molecular level what is responsible for their bright red feathers. The work casts a new light on what is chemically responsible for the colors of birds, and defies previous assumptions and explanations for color variations in parrots, said Kevin McGraw, an assistan...

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