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Tag: "leukemic" at biology news

Man and mouse share genome structures

... technology to characterize chromatin structure in leukemic cells and gain insight into the molecular basis of disease. "The human genome still has many surprises lurking within it," said Lander, director of the Broad Institute and senior author on the study. "One of the most important is the mystery of how ...

Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine

... blood cell that gives rise to CLL, the biology of leukemic lymphocytes and the clinical course of CLL as it relates to the biology, the authors then offer a unifying hypothesis for the development, growth and evolution of the disease, and complete the review with a discussion of the clinical implications for...

Genetically modified natural killer immune cells attack, kill leukemia cells

... that prompts them to aggressively attack and kill leukemic cells. This finding, from researchers at St. Jude ... would become potent killers when they encountered leukemic cells. In order to grow large populations of NK cells, the team started with samples of blood conta...

The very unexpected life and death of a leukemic cell

...d his team calculated birth and death rates of the leukemic cells and found that, contrary to expectations, pr...a that CLL is a purely accumulative disorder where leukemic cells accumulate because they cannot die. Clearly CLL is a disease in which there is a dynamic inter...

Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells

... that prompts them to aggressively attack and kill leukemic cells. This finding, from researchers at St. Jude ... would become potent killers when they encountered leukemic cells. In order to grow large populations of NK cells, the team started with samples of blood conta...

Master regulatory gene found that guides fate of blood-producing stem cells

...l versus differentiation so that all the immature, leukemic cells differentiate and die. Over the past 10 years, several gene families have been suggested to be important in regulating HSC fate-for example homebox, wnt, notch 1, and telomerase genes. Emerson and colleagues figured that one transcription fact...

Stanford/Packard scientist's data-mining technique strikes genetic gold

...ene in which the expression drops significantly in leukemic cells. They also confirmed these relationships by studying genes known to be associated with muscle tissue in both humans and mice. Their classification system was stymied, however, when scientists included too much or too little information in the ...

St. Jude projects 90 percent cure rate for ALL

... whether treatment failure is due to resistance of leukemic cells to drugs, or merely due to the use of inadeq...and elsewhere in identifying specific mutations in leukemic cells that strongly suggest the likelihood that treatment will fail the child, the authors reported....

Mutation in blood stem cells provides clues to cancer development

...ms of blood cancer is partly due to a reservoir of leukemic stem cells that are resistant to current therapies. The discovery of the JAK2 mutation in stem cells in patients with PV is an important first step in developing treatments which target the earliest population of cells which propagate the disease." ...

Cancer scientists create 'human' leukemia process to map how disease begins, progresses

...arose from immature stem and progenitor cells. The leukemic stem cells that were created seemed to change as t...es of transplanted mice. Our findings of how these leukemic stem cells functioned could explain several features of the leukemia in children and adults that als...

Leukemic cells find safe haven in bone marrow

...s in the bone marrow create a protective niche for leukemic cells by releasing large amounts of asparagine, an amino acid that nearby leukemic cells must have to survive but do not make efficiently. This extra supply of asparagine helps leukem...

Major gene study uncovers secrets of leukemia

...ese mutations reduced the level of PAX5 protein in leukemic cells or resulted in the formation of PAX5 protein...s to differentiate into B lymphocytes. In ALL, the leukemic cells fail to differentiate normally and instead remain blocked at an immature stage of development....

Leukemia drug turns mini-molecules up, cancer genes down

...f small molecules called microRNAs (miRNAs) in the leukemic cells. The study also shows that three of these miRNAs inhibit the action of two genes important for cancer development, helping to explain how the drug works. The drug is called all-trans-retinoic acid (ATRA) and it is considered the gold stand...

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