Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis
...lp my lab at St. Jude understand why some cases of leukemia are so difficult to cure," Opferman said. "The mor...o prevents the abnormal white blood cells found in leukemia from undergoing apoptosis in response to chemotherapy or radiation. This makes the leukemia cells re...Viral protein influences key cell-signaling pathway
...t of them, the infection will lead to adult T cell leukemia or lymphoma (ATLL). ATLL is an aggressive disease characterized by a long latent period and the proliferation of T lymphocytes. The virus is spread by sexual activity, by contact with infected blood and by infected women to children through breast mi...UCLA launches $20 million stem cell institute to investigate HIV, cancer and neurological disorders
...aid the groundwork for development of the targeted leukemia therapy Gleevec, is director of the new institute. He also stressed the interdisciplinary approach necessary to face the challenges related to stem cell research. "Embryonic stem cells have the power to develop into every type of human tissue," said ...TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas
...might one day represent an effective treatment for leukemia patients." Other authors of the report include Ayten Kandilci, Cintia Carella, Jonas A. Nilsson, Jennifer A. Brennan, Kelli Boyd, John Cleveland (St. Jude); and Sema Sirma and Ugur Ozbek (Istanbul University). ...The very unexpected life and death of a leukemic cell
B cell chronic lymphocytic leukemia (CLL) is an incurable disease in which cells in th...atic disease of long-lived lymphocytes -- that the leukemia cells were both immortal and born at a slow rate, causing the slow rise in cell count over time. But...Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation
... part of therapy for a variety of diseases such as leukemia or sickle cell disease. In these cases physicians eliminate the patients' own stem cells that produce cancerous white cells or faulty red cells and replace them with healthy stem cells from donors. If the transplants succeed, the donated stem cells r...Placenta Is A Rich Source Of Blood Stem Cells
...stem cells are used in treating blood cancers like leukemia and other blood diseases, and in patients receiving transplants, but growing them in quantity is difficult. The cells don't multiply readily in the laboratory, so they must be harvested from bone marrow by needle aspiration, a painful procedure, or c...Genetically modified natural killer immune cells attack, kill leukemia cells
...dren who receive treatment for acute lymphoblastic leukemia (ALL) or other blood cancers. Results of the St. ...this sample into a dish containing a type of human leukemia cell called K562. Campana's team genetically modified the K562 cells so they carried on their surfac...Enzyme allows B cells to resist death, leading to leukemia
B cell chronic lymphocytic leukemia (B-CLL)is the most common leukemia in adults and is characterized by theprogressive accumulation of mature B lymphocytes in the blood, ...Genome-wide mouse study yields link to human leukemia
... a type of mouse that develops acute lymphoblastic leukemia (ALL). The mouse first goes through a pre-leukemic...aled that the methylation pattern in the mice with leukemia is strikingly similar to the pattern of methylation in human leukemia. In the process, the research...Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
When the most common adult leukemia in the United States was last reviewed by the New ...he world's foremost experts on chronic lymphocytic leukemia (CLL) to write an authoritative update covering the transformation in the scientific community's kno...