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Tag: "leukemia" at biology news

NIH launches comprehensive effort to explore cancer genomics

...ange, such as Gleevec®, a drug for chronic myeloid leukemia and gastrointestinal stromal tumors, and Herceptin®, a drug for one form of breast cancer. These successful developments support further examination of the molecular origins of cancer to more quickly develop new tools to diagnose, treat, and prevent ...

Chernobyl: The true scale of the accident

... no evidence for any increases in the incidence of leukemia and cancer among affected residents." The interna... of 3,940 deaths from radiation-induced cancer and leukemia among the 200,000 emergency workers from 1986-1987, 116,000 evacuees and 270,000 residents of the mo...

HIV inserts into human genome using a DNA-associated protein

...ear cancer genes contributed to the development of leukemia in gene-therapy patients. "This is first example of a cellular factor that's a clear player in target site selection," says Bushman. "This isn't engineering yet, but it's a key piece of information on the way." ...

Dendritic cells offer new therapeutic target for drugs to treat MS and other autoimmune disease

...und that a gene pathway linked to a deadly form of leukemia may provide a new way to treat autoimmune diseases, including multiple sclerosis. Their tests in cell cultures and mice suggest that blocking the pathway by interfering with a blood cell growth gene, known as FLT3, targets an immune system cell often...

U-M scientists discover identifying markers for primitive blood-forming stem cells

... to new medical treatments for sickle cell anemia, leukemia and other types of cancer." As with most discoveries in stem cell science, U-M scientists say their work raises new questions for future research. So far they have identified three SLAM markers on hematopoietic stem cells, but they have no idea what...

Genes linked to treatment resistance in children with leukemia

...hers studied 246 children with acute lymphoblastic leukemia (ALL), all of whom were assigned to one of two gro...tudy. The researchers also looked for evidence of leukemia in each patient's central nervous system (CNS), a region that is vulnerable to infiltration by cance...

Protein structure key for AIDS, cell function

...hanisms involved in certain diseases, ranging from leukemia to diabetes and HIV-AIDS. Levels of the protein climb, for reasons unknown, when people fall ill, making human CD38 a marker for these diseases. As one example, researchers have shown that CD38 interrupts an interaction between the AIDS virus an...

A Father’s Day Gift: Free DNA Paternity Testing

...products. One of the most effective treatments for leukemia is based on derivatives of a sponge while a sponge-derived steroid compound completed phase one US trials as an asthma drug in 2000. Other research in progress includes treatments for breast and ovarian cancer. Impediments to this research include n...

Clear rules needed to govern deep sea bioprospecting: UNU

...products. One of the most effective treatments for leukemia is based on derivatives of a sponge while a sponge-derived steroid compound completed phase one US trials as an asthma drug in 2000. Other research in progress includes treatments for breast and ovarian cancer. Impediments to this research include n...

Sleeping beauty plays a significant role in identifying cancer genes

...y genes for tumors in the brain, melanoma, breast, leukemia and lymphoma. Largaespada, Jenkins and Copeland acknowledge the difference between research in mice and actual use in humans. But as Largaespada pointed out, "We have proof of principle that we're on the right track. We know that some of the same ge...

NIH renews network focused on how genes influence drug responses

...cer drugs, including those used to treat childhood leukemia and colorectal cancer. (Mark Ratain, M.D., University of Chicago, and Mary V. Relling, Pharm.D., St. Jude Children's Research Hospital) Pharmacogenomics of Arrhythmia Therapy --$14 million provided by NHLBI to discover the common DNA variant...

Gene therapy advance treats hemophilia in mouse models

...ed feline immunodeficiency virus (FIV). FIV causes leukemia in cats but no disease in humans. The hybrid vehicle efficiently bound to receptors on the liver cells because the modified baculovirus coat serves as a "key" that fits into the "lock," or receptor. The percentage of liver cells that took up the vi...

Micro-molecule plays big role in birth defects

...if you remove two microRNAs from the human genome, leukemia develops," Harfe said. "We envision our mouse model may be a tool to directly test how microRNAs are involved in human cancers." ...

Retroviral resistance gene found

...Z1, that can mediate a potent resistance to murine leukemia virus, as well as HIV-1, in cell culture. The researchers found that the high level of FEZ1 expression in a specific laboratory rat cell line caused a significant block to retroviral infection ?retroviruses were able to enter the host cells and synth...

Cancer drug slows poxvirus in mice

...a rare form of cancer known as chronic myelogenous leukemia (CML). Gleevec inhibits Abl-family tyrosine kinases and has proved very useful in treating CML. To learn whether Gleevec could prevent or lessen vaccinia's ability to spread in a living organism, the researchers treated mice with either saline solut...

Researchers pioneer new gene therapy technique using natural repair process

... a disabled virus, but some subsequently developed leukemia because the virus inadvertently turned on a cancer gene. Dr. Porteus' strategy differs fundamentally from previous gene therapies because it essentially replicates the natural process, which is more accurate. This accuracy means that, in practice, t...

Science study holds implications for gene therapy and stem cell biology

... into a single blood-forming stem cell can lead to leukemia in mice, because several "signaling" genes were ac...erted to repopulate the entire blood system, as in leukemia treatment. The process has the potential to treat inherited blood disorders, as demonstrated in an ...

Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia

...standing of why some pediatric acute lymphoblastic leukemia (ALL) patients fail to respond to treatment even when existing clinical predictive criteria point towards a positive treatment outcome. The research, published in the April issue of Cancer Cell, is likely to facilitate development of new strategies t...

FDA Works To Speed The Advent Of New, More Effective Personalized Medicines

...astatic breast cancer, Gleevec for chronic myeloid leukemia and Erbitux for metastatic colorectal cancer. "FDA's efforts will bring us one step closer to 'personalizing' medical treatment," explained Janet Woodcock, M.D., Acting Deputy Commissioner for Operations, FDA. "This new technology will allow medicin...

Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells

...dren who receive treatment for acute lymphoblastic leukemia (ALL) or other blood cancers. Results of the St. ...this sample into a dish containing a type of human leukemia cell called K562. Campana's team genetically modified the K562 cells so they carried on their surfac...

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