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The secret lives of whales

... it, and drop it to the sea floor. The transponder lets them find it later with a manned submersible or robotic vehicle. They now know that a whale fall may host even more species than a hydrothermal vent—many unique to whale falls. Recently discovered “blind zombie worms?use an internal “bacterial garde...

Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation

...lting combination of genes to make a receptor that lets the cell recognize a specific target. When stimulated to multiply, each of those cells produce an army of immune cells against their designated target. Specific infectious organisms or other foreign substances stimulate T cells to divide and multipl...

Protein offers way to stop microscopic parasites in their tracks

...d Toxoplasma genome to search for the protein that lets the parasite detach glue spots at the back of the belt. Scientists led by the Institute for Genomic Research in Rockville, Md., posted the completed Toxoplasma genome online last year. Geneticists at Washington University's Genome Sequencing Center c...

Effective Cancer Treatments Follow The Clock

...the molecular mechanism of internal clock function lets us make some important predictions of how these mice may respond to drug treatment,?said Antoch. “Thus, defects in Clock or Bmal1 genes, which essentially damp the cycles of the internal clock may produce very different effect when compared to defect...

Some Brain Cells 'Change Channels' To Fine-tune The Message

...hannel, or membrane opening, for another. Doing so lets the cells fine-tune their messages and adjust connections within the cerebellum, the brain region that controls fine motor skills. Although the cells' channel-changing ability has been recognized for a few years, the key players controlling it hadn'...

Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol

... our industry collaborator has provided a way that lets us test real enzyme activity within a human tumor sample," he says. "Our hope is to be able to use this system as a molecular marker to assess whether an anti-cancer therapy is working." ABSTRACT # 1670 Sensitivity to Tarceva Depends on CDK2 In th...

Doing a spin with DNA

... cuts through one of the two DNA strands, and then lets the DNA unwind before sticking the broken ends back together again. With the help of sensitive measuring devices, the researchers could measure various parameters such as the friction of the rotating DNA in a cavity of the enzyme. The research has pr...

Future diabetes drugs may target new protein interaction

...rs increased production of sirtuin1, which in turn lets PGC1 start converting the pyruvate into the glucose the body needs to survive." The relationship between sirtuin1 and PGC1 also connects processes involved in cellular aging and responding to calorie intake in mammals for the first time. In bacteria...

PHACCS, an online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information

...rs increased production of sirtuin1, which in turn lets PGC1 start converting the pyruvate into the glucose the body needs to survive." The relationship between sirtuin1 and PGC1 also connects processes involved in cellular aging and responding to calorie intake in mammals for the first time. In bacteria...

Computational verification of protein-protein interactions by orthologous co-expression

...rs increased production of sirtuin1, which in turn lets PGC1 start converting the pyruvate into the glucose the body needs to survive." The relationship between sirtuin1 and PGC1 also connects processes involved in cellular aging and responding to calorie intake in mammals for the first time. In bacteria...

Eliminate Data Analysis Bottlenecks in Drug Discovery

...rs increased production of sirtuin1, which in turn lets PGC1 start converting the pyruvate into the glucose the body needs to survive." The relationship between sirtuin1 and PGC1 also connects processes involved in cellular aging and responding to calorie intake in mammals for the first time. In bacteria...

Some Brain Cells Change Channels

...hannel, or membrane opening, for another. Doing so lets the cells fine-tune their messages and adjust connections within the cerebellum, the brain region that controls fine motor skills. Although the cells' channel-changing ability has been recognized for a few years, the key players controlling it hadn'...

Immune system's distress signal tells bacteria when to strike back

...tion notice from your landlord," Alverdy said. "It lets them know they need to find a new home. They don't take that news any better than we would." A vulnerable host, like a condemned home, is a liability, a threat to its tenants' survival. Pseudomonas, however, has the tools to engineer its own escape ...

Slipping past the blood brain barrier: Research shows potential treatment for brain cancer

...barrier is set up to very carefully patrol what it lets into the brain and what it keeps out. It makes these decisions based on the physicochemical properties," says Dr. Banks, who also is a staff physician at Veterans Affairs Medical Center in St. Louis. "Most of our drugs that fight cancers are toxic t...

Hopkins scientists uncover 'tags' that force proteins to cell surface

...t use one of these "tags" are the ion channel that lets heart cells contract on cue, and the docking point that allows HIV, the virus that causes AIDS, into cells, the researchers discovered. Because proteins on the cell surface are "lock-on" sites for drugs and other molecules, as well as triggers of im...

Why do aneurysms form? New studies suggest leading role for white blood cells

...porarily, and in rats that lacked the protein that lets neutrophils attach to tissue and start the "first aid" process. The researchers exposed a small part of the rodent aortas to a chemical that breaks down blood vessel tissue, then studied what happened in the rodents that had altered neutrophil system...

Computers close in on protein structure prediction

Rosetta@home lets public participate in structure prediction. Computers can predict the detailed structure of small proteins nearly as well as experimental methods, at least some of the time, according to new studies by Howard Hughes Medical Institute researchers. T...

Researchers discover why melanoma is so malignant

...mediately reawaken a dormant cellular process that lets them travel swiftly throughout the body. Central to this reawakened process is a gene called Slug (named after the bizarre embryo shape that its mutated form can cause in fruit flies). Slug is active in the neural crest, an early embryonic cluste...

PET imaging reveals the immune system at work

... recruit key disease-fighting immune cells. "This lets us see not only how but where" the body is responding to disease, Witte explained. "The immune system resides throughout the body, and it is not going to be responding the same everywhere." Moreover, a whole-body perspective, Witte said, may be espe...

Jefferson biologist coaxing human embryonic stem cells to make dopamine with simpler, faster method

... recruit key disease-fighting immune cells. "This lets us see not only how but where" the body is responding to disease, Witte explained. "The immune system resides throughout the body, and it is not going to be responding the same everywhere." Moreover, a whole-body perspective, Witte said, may be espe...

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