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Tag: "lethal" at biology news

Largest synthetic gene ever built offers insights into anti-malarial drug resistance

...ey are moving closer to understanding why the most lethal form of human malaria has become resistant to drug treatment in the past three decades. They have been able to artificially construct, and then express in yeast, a protozoan gene that contributes to such resistance. And it was no small feat. The gene...

Research shows cord blood comparable to matched bone marrow

...r risk of graft versus host disease, a potentially lethal complication, especially when HLA types are mismatched. Rates of leukemia relapse also are lower with mismatched umbilical cord blood transplants. This study also showed that in addition to having a good match, higher cell doses for umbilical cord bl...

Staphylococcus aureus hides out in cells

.... Simultaneously, production of toxins potentially lethal for the epithelial cells becomes strictly controlled to limit cellular damage. Mechanisms that helped the bacteria to survive and/or multiply, including metabolic and energy production functions, then resumed. Although most of the bacteria had died b...

Runners -- Let thirst be your guide

...types of endurance exercise at risk of potentially lethal water intoxication, say international experts who study disorders of water metabolism. Such exercise includes marathons, triathlons, and long distance cycling. This serious condition, known as exercise-induced hyponatremia (EAH), could be prevented ...

Genome of Clostridium botulinum reveals the background to world's deadliest toxin

...ome of the organism that produces the world’s most lethal toxin is revealed today. This toxin is the one real weapon in the genome of Clostridium botulinum and less than 2 kg — the weight of two bags of sugar — is enough to kill every person on the planet. Very small amounts of the same toxin are used in me...

Human stem cell treatment restores motor function in paralyzed rats

...ta, a major blood vessel, to correct a potentially lethal aneurysm, blood flow from the heart must be temporarily blocked with a clamp. After 30 minutes, this lack of blood flow can result in the death of specialized spinal cord neurons called spinal inhibitory neurons, leading to irreversible spasticity ...

Peramivir protects mice from lethal H5N1 infection

...vir to mice one hour after nasally administering a lethal Vietnam strain of H5N1 influenza virus. The researchers reported 100 percent survival among 10 infected mice given intramuscular injections of peramivir daily for eight days. The drug also inhibited replication of the deadly strain of H5N1 virus i...

Anthrax paralyzes immune cells with lethal toxin, UF research shows

...eting toxins." Once inhaled, anthrax releases a lethal toxin that immobilizes the white blood cells that ...s. "We've discovered that through this pathway, lethal toxin blocks the function of a protein that regulates how actin assembles," said Southwick, who beli...

Cornell lab confirms deadly fish virus spreading to new species

A lethal fish virus in the Great Lakes and neighboring waterways is approaching epidemic proportions, according to Paul Bowser, Cornell professor of aquatic animal medicine in the College of Veterinary Medicine. The viral hemorrhagic septicemia virus (VHSV), ...

Researchers wake up viruses inside tumors to image and then destroy cancers

...ered to carry therapeutic radionuclides, which are lethal to cells in which TK is activated. Results of this study suggests that this strategy could be applied to other viruses associated with tumors, and that other drugs may potentially be used to activate these viruses, Pomper says. "Velcade is only on...

Corals that can fight global warming may one day help fragile reefs

...ost their cellular and enzymatic defenses to fight lethal microorganisms as temperatures rise. These abiliti...igh-resolution satellite detectors) are related to lethal coral reef epidemics. The warm temperatures that have been occurring worldwide as a result of glob...

Soft-cell approach cuts animal tests

...ed to inhibit cell growth, mirror well-established lethal values obtained from animal studies - a long-estab... this occurs is the LD50 test, where LD stands for lethal dose. This heavy reliance on animal data in toxicology has long been a concern of the scientific...

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease

...roof-of-concept, a mouse model of a representative lethal neurodegenerative disease. Next, they used mouse n...eficient and, therefore, has Sandhoff's Disease, a lethal genetic disease related to Tay-Sachs Disease. When stem cells were implanted -- at simply one time p...

Saving endangered whales at no cost

... North America. A leading threat to the species is lethal entanglement by fishing gear: Photographic evidence indicates that 75% of individuals show signs of entanglement, mostly from lobster fishing gear. In the new work, the researchers analyzed the costs and benefits of two dramatically different lob...

Mailman School of Public Health researchers report blood DNA can be early predictor of liver cancer

...essing the challenges that result from this highly lethal form of cancer.? Dr. Santella and the team of researchers previously found that several environmental factors including aflatoxin B1, a dietary mold contaminant sometimes found in peanuts and corn; polycyclic aromatic hydrocarbons, ubiquitous envir...

New study may show how to forestall a fatal, virus-caused immune-system meltdown

...h cancers was activated late in infection with the lethal strain of the virus. “We can go in and design an experiment where we can start testing drugs that already have FDA approval,?Bowick said. “If we can go straight from discovery to drug candidates, that’s quite a big leap for us, and one that may be ve...

DNA ends: Common tool, different job

...tion or end-to-end fusions. Such repair events are lethal for the genome, and in certain settings, can promote the development of cancer. About 10 years ago, Lundblad discovered that Cdc13, a protein that binds single-stranded telomeric DNA, plays a central role at the telomeres of baker's yeast. But the...

Study uncovers a lethal secret of 1918 influenza virus

...ervene and stop or mitigate the virus' potentially lethal effects, Kawaoka says. "Things may be happening at an early time point (in infection), but we may be able to step in and stop that reaction."...

2,000 influenza virus genomes now completed and publicly accessible

... pandemic caused by the emergence of a new, highly lethal virus strain that is easily transmitted from perso...occurred three times in the last century, the most lethal of which was the pandemic of 1918, which caused an estimated 40 to 50 million deaths worldwide. "...

Fruit fly gene research may shed light on human disease processes

...h sex. Failure to properly count X chromosomes is lethal to embryos of mammals and flies. That's why biologists want to understand the process of "chromosome counting." Early in his career, Erickson was part of the research team that identified the genes involved in counting Drosophilia sex chromosomes...

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