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Tag: "leptin" at biology news

Weight control protein may yield antiobesity drugs

...chigan Medical School. Produced by fat tissue, the leptin hormone sends signals to the brain about the body'...reveal SH2-B as an important positive regulator of leptin sensitivity inside cells of the brain region known as the hypothalamus," said senior author of the s...

Machinery of the 'marijuana munchies'

... inhibition" (DSI). What's more, they found that leptin inhibits DSI. However, they found that leptin did not interfere with the CB1 receptors themselves. Rather, leptin "short-circuits" the endocannabi...

Sleep deprivation doubles risks of obesity in both children and adults

...ther effects, stimulates appetite and creates less leptin which, among other effects, suppresses appetite. However he says more research is needed to understand the mechanisms by which short sleep is linked to chronic conditions of affluent societies, such as obesity, diabetes and hypertension. Francesco ...

Leptin found to control appetite and limb development in frogs

...Xenopus. As it does in humans and other mammals, leptin acts on the frog brain to suppress appetite. But t...y of Michigan. Denver's team gave frogs a dose of leptin at various stages of development from tadpole to near adult and watched what happened. As in mice, t...

Leptin has powerful effect on reward center in the brain

... In this study the researchers demonstrated that leptin signaling, via its receptor, occurs in the dopamin...diction and reward. Reducing the function of the leptin receptor in the VTA region resulted in animals that ate too much and were hypersensitive to highly p...

Major link in brain-obesity puzzle found

...t, the action of the metabolic signaling molecules leptin and insulin, and the use of energy from food. It e...dies lose the ability to sense the signals sent by leptin and insulin that tell the brain to slow down food intake and fat storage. For the new paper, the...

Rewarding fat rats

...a lot during holidays, for example, will make more leptin than a person who sticks to a stricter diet. I... a diet to reduce their fat mass and, hence, their leptin levels. They found that restricting the rats' diet to one meal per day not only made them lose weigh...

Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight

...owever, in this model, lack of EP3 did not prevent leptin increase. "Something is happening there in that circuit," says Sanchez-Alavez. "The PGE2 and leptin may be interacting and controlling eating behavior." Bartfai notes, "Inflammation as part of the ...

How appetite-stimulating brain cells work overtime during fasting

... that decreased levels of the fat-produced hormone leptin alone signaled the hypothalamus that fat levels have fallen, leading hypothalamic neurons to activate a program, including hunger, to preserve energy and restore fat levels, he said. Now, "a series of studies, including those reported in this iss...

In obesity, brain becomes 'unaware' of fat

...es designed to inhibit SOCS-3 may therefore bypass leptin resistance in obese animals to restore energy bala...hypothalamus, known as the ARH, is a major site of leptin sensing, harboring neurons that control appetite. More than 60 percent of American adults are now...

Research finds that circadian rhythms dominate all life functions

...ite phase. These genes are essential components of leptin signaling system, responsible for the sensation of...s in different organs and determines the effect of leptin on regulation of the energy balance. Better understanding gene oscillation may provide researchers w...

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