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Tag: "led" at biology news

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...cancers. In the Jan. 28 issue of Cell, scientists led by Bruce Spiegelman, PhD, report that the harmful effects of saturated and trans fats are set in motion by a biochemical switch, or co-activator, in liver cells called PGC-1beta. Until now, scientists lacked a detailed explanation of how saturated a...

Genes In The Interferon System Important In Systemic Lupus Erythematosus

...he interferon systemin a number of works. This has led to the recognition of theirhypothesis in the last year, and today it represents a white-hot fieldof research that has attracted a great deal of interest in thepharmaceutical industry. This picture has now been further reinforcedby new findings­ - the...

W.M. Keck Foundation funds study of friendly microbes

...nce and engineering. The grant supports a project led by Jeffrey Gordon, M.D., director of the Center for Genome Sciences (CGS) at Washington University in St. Louis, and reflects a partnership between his lab, the lab of Sean Eddy, Ph.D., associate professor of genetics, and members of the Washington U...

Yellowstone microbes fueled by hydrogen, according to U. of Colorado study

...ide the human body.A team of CU-Boulder biologists led by Professor Norman Pace, one ofthe world's leadin...temperature.A combination of three different clues led researchers to conclude thathydrogen was the main source of energy. Genetic analysis of thevarieties...

Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs

...lled " intermittent claudication ".The Emory team, led by cardiologist Arshed A. Quyyumi, MD, andcardiology fellow Veerappan Subramaniyam, MD, is using colonystimulating factors (growth factors), to prod the bone marrow torelease a type of stem cells called endothelial progenitor cells, whichare used by ...

Fox Chase Cancer Center scientists identify immune-system mutation

A team of Fox Chase Cancer Center scientists led by immunologist Dietmar J. Kappes, Ph.D., has identified the genetic mutation that keeps a mouse strain from developing white blood cells, or lymphocytes, called helper T cells. The report by Kappes and his colleagues appears in the Feb. 24 issue of ...

Neuronal 'traffic jam' marks early Alzheimer's disease

...ts for the disorder, they said. The research team led by Lawrence S. B. Goldstein, a Howard Hughes Medical Institute investigator at the University of California, San Diego (UCSD), reported their findings in the February 25, 2005, issue of the journal Science. Goldstein and his colleagues at UCSD collab...

Elusive HIV shape change revealed; Key clue to how virus infects cells

...ide vaccine and treatment approaches. Researchers led by Howard Hughes Medical Institute Investigator Stephen Harrison, PhD, and Bing Chen, PhD, focused on the gp120 protein, part of HIV's outer membrane, or envelope. gp120's job is to recognize and bind to the so-called CD4 receptor on the surface of t...

Mouse brain cells rapidly recover after Alzheimer's plaques are cleared

...hed and stable, but clearing out the plaques often led to rapidrecovery of normal structure over a few days," says senior author DavidH. Holtzman, M.D., the Charlotte and Paul Hagemann Professor and headof the Department of Neurology. "This provides confirmation of thepotential benefits of plaque-clearin...

Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer

...ncing of E. histolytica was a collaborative effort led by The Institute for Genomic Research (TIGR) in Rockville, MD, and by the Wellcome Trust Sanger Institute in the U.K. The project was supported by grants from the National Institute of Allergy and Infectious Diseases (NIAID), which is part of the Nat...

Key molecule in plant photo-protection identified

...hed and stable, but clearing out the plaques often led to rapidrecovery of normal structure over a few days," says senior author DavidH. Holtzman, M.D., the Charlotte and Paul Hagemann Professor and headof the Department of Neurology. "This provides confirmation of thepotential benefits of plaque-clearin...

Timing is everything: First step in protein building revealed

...ng is everything, it seems, even inscience. A team led by Johns Hopkins scientists has unraveled the firststep in translating genetic information in order to build a protein,only to find that it's not one step but two.In a series of experiments, the scientists found that when yeast'sprotein-building mach...

Researchers Uncover Key Step In Manufacture of Memory Protein

...ng-term memory, according to a team of researchers led by scientists at the National Institute of Child H...alth and Human Development. The research team was led by Y.Peng Loh Ph.D, of NICHD’s Section on Cellular Neurobiology. The researchers published their wor...

Research advances quest for HIV-1 vaccine

...entry of HIV-1 into human cells. A research group led by Drs. Dennis R. Burton and Ian A. Wilson from The Scripps Research Institute in La Jolla, California performed a study examining the detailed molecular structure of the complex formed when 4E10 binds to gp41 and determining how interaction of 4E10 ...

HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs

...ately researchers from the University of Wisconsin led by Craig January, M.D., Ph.D., discovered that protease inhibitors do block these key channels. "Our findings suggest that as a class, protease inhibitors may predispose individuals to QT interval problems or torsade de pointes," Dr. Badley says. Dr...

Whole genome fine map of rice completed

... of PLoS Biology (Vol.3 Issue 2, 2005), scientists led by the Beijing Institute of Genomics (BIG) reported a "much improved, near-complete genome analysis of the indica and japonica subspecies of O. sativa." The fine maps of the rice genome sequences will lay a solid foundation for studying the differen...

“Nano-scissors?laser shows precise surgical capability

...l engineering atThe University of Texas at Austin, led the development of thetechnique. It acts like a pair of tiny “nano-scissors,?able to cut,for example, nano-sized units like nerve axons, the parts of nervecells that carry nerve impulses away from the cells to muscles or toother cells.“This tool open...

U-M scientist to talk about tissue engineering at AAAS

...ot heal on their own, Krebsbach said, and that has led to research in biomaterials, bone and connective tissue function, and then tissue engineering. At Michigan, tissue engineering collaboration includes dentists, M.D.s and engineers, among others. They all bring a different perspective, and it leads t...

Gene therapy converts dead bone graft to new, living tissue

...ature Medicine. The procedure, designed by a team led by Edward M. Schwarz, Ph.D., associate professor of orthopedics and of microbiology and immunology at the University of Rochester Medical Center, is intended to eventually aid people with various cancers or injuries whose treatment involves the repla...

Jefferson Virologists Coax HIV Out of Hiding

...tem.Now, virologists at Jefferson Medical College, led by Roger J.Pomerantz, M.D., professor of medicine, biochemistry and molecularpharmacology and director of the Division of Infectious Diseases andEnvironmental Medicine at Jefferson Medical College of Thomas JeffersonUniversity in Philadelphia, may ha...

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