Gut research yields new anti-cancer approach
...out causing significant toxicity. That provides at least the hope that the drug class may not be prohibitiv...umped out by drug efflux proteins is known, and at least one of the PPARgamma inhibitors does not match it. In addition, PPARgamma inhibitors do not bind to ...Glucose triggers brain cell death in rats after hypoglycemic coma
...ut evidence of significant oxidative stress for at least 60 minutes," says Swanson, who is also professor and vice-chair of neurology at the University of California, San Francisco. "It was only when we gave them glucose to reverse the hypoglycemia that the oxidative stress occurred. This was a real surpr...Human's ecological footprint in 2015 and Amazonia revealed
...ors. Restricting their data to countries of at least one million people, Dietz and colleagues calculated basic forms of consumption, including crops, meat, energy, and living space, using data from the World Wide Fund for Nature. United Nations reports were used to measure human well-being, population...The sturdier sex? -- Study by Pittsburgh scientists finds female stem cells work better
...erences in aging and disease and could explain, at least partially, the high variability and conflicting results reported in the literature on stem cell biology." Dr. Huard’s team, and the study’s first author, Bridget Deasy, PhD, director of the Live Cell Imaging Lab at Children’s Stem Cell Research Ce...New details on how the immune system recognizes influenza
... has developed towards one strain might provide at least some protection against the other strain. Using a software tool they developed, the LIAI team found hundreds of conserved influenza virus epitopes in the database, including those between avian H5N1 and strains of human influenza viruses. But what...Tracking sperm whales and jumbo squid
...rote. At night, however, the tagged squid spent at least half of their time in shallower waters above 600 feet and the remainder at 600 to 1,300 feet. One likely explanation for this vertical movement is that the squid were following small fish and other prey that migrate toward the surface at night and th...How appetite-stimulating brain cells work overtime during fasting
...othalamic responses to food deprivation involve at least three hormones, two cell types, and an unexpected interlocutor, uncoupling protein 2." ...Stress may help cancer cells resist treatment, research shows
...men who took beta blockers for hypertension for at least four years had an 18 percent lower risk of prostate cancer," said Kulik. "These drugs block the effects of epinephrine, which could explain the finding. Another study of men after radical prostatectomy reported increased mood disturbances, which are...Fighting influenza & co. with 40,000 blood samples
...esidual viruses. Spanish flu took the lives of at least 25 million people between 1918 and 1920. But the disease was not only exceptional because of its extreme virulence. The patho-gen, the influenza virus subtype A/H1N1, homed in on women and men in the prime of their lives. 'Normally respiratory diseas...Misclassified for centuries, medicinal leeches found to be 3 distinct species
... shows that wild European medicinal leeches are at least three distinct species, not one. The results appear in the April 10, 2007, online version of the journal Proceedings of the Royal Society B. "This raises the tantalizing prospect of three times the number of anticoagulants, and three times as many...Common gene version optimizes thinking -- but with a possible downside
...tion. Three fourths of subjects studied had at least one copy of the version that results in more efficient filtering of information processed by the brain's executive hub, the prefrontal cortex. However, the same version was also more prevalent among people who developed schizophrenia, a severe mental...Research finds music training 'tunes' human auditory system
... to 20 adults as they watched a movie. Half had at least six years of musical instrument training starting before the age of 12. The other half had minimal (less than 2 years) or no musical training. All were native English speakers with no knowledge of Mandarin, a tone language. In tone languages, a s...Gene elevating breast cancer risk also causes prostate cancer
...nherited predisposition seems to be involved in at least 5?0 per cent of all cases of breast cancer. The two major familial breast cancer susceptibility genes BRCA1 and BRCA2 only explain 20-30 per cent of families with site-specific female breast cancer, which suggests the contribution of additional susce...Anxiety disorders surprisingly common yet often untreated
...f patients seen by primary care physicians have at least one anxiety disorder. The study outlines the effectiveness of a new screening tool which can alert busy primary care physicians to those patients with one or more anxiety disorders. The study is published in the March 6 issue of the Annals of Intern...Robotic therapy helps restore hand use after stroke
...sting Robotic Device (HOWARD). Each patient had at least moderate residual weakness and reduced function of...ven women and six men who had suffered a stroke at least three months prior participated in the pilot study using this robotic device. "Most spontaneous ...How badger culling creates conditions for spread of bovine TB
...found that TB rates were lowest when there was the least movement of individual badgers between groups. There have been few experimental studies of the incidence of infectious disease in socially-structured wildlife populations, and this study shows that such information is crucial to understanding how ...The price of vanity: Mating with showy males may reduce offspring's ability to fight off pathogens
... size to roe production and mate selection may, at least in some cases, counter the immunosuppressive effects of elevated testosterone in females." ...Ebola outbreaks killing thousands of gorillas and chimpanzees
... also fed simultaneously in the same fruit tree at least once every seven days. The study also provided the first evidence that gorillas from one social group closely inspect the carcasses of gorillas from other groups. Contact with corpses at funerals is a major mechanism of Ebola transmission in huma...Cartilage discovery offers arthritis hope
...dler. "This research, while just a beginning, at least establishes some basic scientific facts that could prove useful in future studies on osteoarthritis and related conditions." The next stage of the team's work will be to determine the structure of the thicker fibrils and examine how collagen cells ......strate very strong associations between DT2 and at least four genes encoding proteins playing major roles in the development of the pancreas and of insulin-producing cells: TCF7L2, HHEX, EXT2 and SLC30A8. TCF7L2 and HHEX encode transcription factors (molecules regulating the activity of other genes) co...