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Tag: "latent" at biology news

New vaccine prevents CMV infection and disease in mice

...a number of diseases associated with persistent or latent infections, including all types of herpes-associated diseases, AIDS, or hepatitis,” said Spector. These viruses persist because immune responses generated by the viral infection are not able to eradicate the virus....

'Insulator' helps silence genes in dormant herpes virus

... escape detection by the body's immune system, the latent virus works to silence genes that would cause it t...rs play a role in silencing viral genes during the latent phase, Zhou and his group studied cells infected with HSV-1. The studies showed that during a latent...

Herpes infection may be symbiotic, help beat back some bacteria

...ne system triggered by the long-term presence of a latent herpes virus infection. In latent viral infections, the virus is present for the lifetime of the host in a relatively quiescent form t...

Latent memory of cells comes to life

...Danish research has examined the mechanisms behind latent cell memory, which can come to life and cause prev...e types. The effect of these changes can be that a latent capacity that was dormant comes to life, or, conversely, that a previously active capacity shuts dow...

Researchers wake up viruses inside tumors to image and then destroy cancers

...per says. "So we were hoping to find a way to turn latent Epstein-Barr virus on in these cancers, and use the thymidine kinase it then produces to enable us to see the virus-associated tumors with radiolabeled FIAU." The researchers screened 2,700 agents until they hit upon Velcade, a targeted chemothera...

Synthetic peptide targets latent papilloma virus infections

... to rid oneself of the virus because it hides as a latent DNA in cells of the epithelial tissue, such as ski...ere they again take up residence in the nucleus as latent viral DNA. The viral plasmids turn into infectious viruses only in the top, differentiated layers of...

Cold sore virus might play role in Alzheimer's disease

...t" phase. The virus spends most of its time in the latent phase, sequestered in cells, not active and not re...gene, the virus is less likely to be in the quiet, latent stage of its life cycle, suggesting it has more of an opportunity to replicate. In animals with the ...

Chemo combination improves survival in asbestos-related cancer

...ay of diagnosing the premalignant phase during the latent period of 15 to 20 years," Green added. "Many of these patients smoke and are in economically disadvantaged communities. Many individuals have moved away from heavy industries and may not admit or know they were exposed to asbestos as young men, with...

Scientists find potential 'off-switch' for HIV virus

...cific genetic trigger that makes HIV fall into its latent phase, where the virus essentially hibernates, rel... latency, and it might serve as a useful model for latent infections by other viruses, as well," said Shenk, Princeton's James A. Elkins Jr. Professor in the ...

Finnish scientists discovered a new approach to treat virus-induced lymphomas

...uced PEL. KSHV displays two patterns of infection: latent and lytic phase. During latency, only a restricted set of viral genes is expressed. The KSHV genome encodes several homologues of cellular proteins, which engage cellular signaling pathways, govern cell proliferation and modulate apoptosis. Major...

Bad blood between boys and girls

...y. Kankova and colleagues analysed the effect of latent (or dormant) toxoplasmosis on the probability of the birth of a boy in humans. Latent toxoplasmosis is asymptomatic but is usually a life-long infection characterised by the presence of anti-Toxoplasma antibodies in the blood. They analysed over ...

A simple feedback resistor switch keeps latent HIV from awakening

...ircuit shutoff and possibly the stability of HIV's latent state. In the Tat resistor model, as in the cell, Tat deacetylation occurs at a much faster rate than acetylation. Deacetylated (inactive) Tat can take one of two paths--reconversion in to acetylated (active) Tat, or destruction of the protein by...

Interfering RNA silences genes in 'slippery' immune cells

...ious research strongly suggests that HALP promotes latent HIV infection, the new technique has a potential application to HIV treatment. "The siRNA may represent a suicide vector: by knocking down HALP it may allow HIV-infected cells to self-destruct, thus eliminating a hiding place for the virus," said Dr....

Infected for life

...d a microRNA (miRNA) as the culprit that keeps the latent virus-infected cell alive. These findings could on...nd offers the first target for intervention in the latent infection. A research team led by Nigel W. Fraser, PhD, Professor of Microbiology, has found that h...

Cancer virus protein needed for successful infection

...LL), an aggressive disease characterized by a long latent period and the proliferation of T lymphocytes. The virus is spread by sexual activity, infected blood and breast milk. For this study, Lairmore and a group of collaborators developed a mutant strain of HTLV-1 that lacked p13. The researchers then i...

A case of mistaken molecular identity

...ization, but the number of people who are carrying latent infections is unknown. "We now know that Chagas patients may have trouble seeing at night," said Levin. "And this gives us additional motivation to improve conditions for people living in areas where Chagas disease is common." Silvia Matsumoto, a ...

Dogs keep dying: Many owners unaware of toxic dog food

...soned from those that have not. Unfortunately, the latent onset of signs may require that an individual dog be evaluated several times." Cornell veterinarians have verified diagnostic tests enabling detection of seriously poisoned dogs. Aflatoxin curtails the production of cholesterol and many proteins th...

Treating populations infected with HIV and latent TB could speed the emergence of drug-resistant TB

... HIV and TB, they are more likely to progress from latent TB infection to active TB. To combat the problem...rapy to reduce the risk that TB will progress from latent infection to active disease. However, researchers from the Harvard School of Public Health (HSPH) an...

Viral protein helps infected T cells stick to uninfected cells

...LL), an aggressive disease characterized by a long latent period and the proliferation of T cells. The infected cells are spread from person to person during sexual activity and by blood and breast milk. In the body, the HTLV-1 mainly targets immune-system cells known as CD4 T lymphocytes. These immune ce...

Waking a sleeping virus

...ZEBRA is essential to switching the virus from its latent to its active state. "During an infection, EBV ins...n 10 genes are sufficient for the virus during its latent state, whereas all others are necessary to produce new viruses and to infect new host cells. Those h...

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