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Tag: "lacking" at biology news

Novel Enzyme Shows Potential As An Anti-HIV Target

...Experiments using cells taken from transgenic mice lacking SIRT1 demonstrated that introducing human SIRT1 enzymes increased Tat’s transcriptional effects in a dose-dependent manner, while treating cells with the small molecule HR73, a derivative of a molecule that inhibits the yeast version of the SIRT1 pro...

An HIV Protein Plays a Surprising Role in Gene Activation

...t-driven transcription proceeded as usual in cells lacking TAFs. And they demonstrated that it is Tat—along with its cofactor P-TEFb, which is normally bound to RNA through Tat—that recruits the TAF-deficient TBP. Altogether, these results show a surprising new role for Tat in stimulating assembly of a tran...

Scientists discover the cellular roots of graying hair

...death?genecalled Bcl2, Fisher’s team analyzed mice lacking this gene. In adramatic fashion, the mice lost the...ccessfully treat melanoma.?The team also made mice lacking a gene, MITF that regulates Bcl2. Thesemice also went gray, but more gradually than did the mice tha...

Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery

...death?genecalled Bcl2, Fisher’s team analyzed mice lacking this gene. In adramatic fashion, the mice lost the...ccessfully treat melanoma.?The team also made mice lacking a gene, MITF that regulates Bcl2. Thesemice also went gray, but more gradually than did the mice tha...

Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.

...death?genecalled Bcl2, Fisher’s team analyzed mice lacking this gene. In adramatic fashion, the mice lost the...ccessfully treat melanoma.?The team also made mice lacking a gene, MITF that regulates Bcl2. Thesemice also went gray, but more gradually than did the mice tha...

Same mutation aided evolution in many fish species, Stanford study finds

...is group found that several species of stickleback lacking hind fins all shared an alteration in how a gene was turned on and off. The striking similarity is that in both studies evolution turned to the same genetic switch to work a visible change in the fish. However, in the fin study the group wasn't able...

Scientists identify new model Of NK cell development

...laboratory, had noted other work showing that mice lacking lymph nodes also lacked NK cells. In addition, in ...while full of CD56 bright cells, are significantly lacking in their counterparts, the CD56 dim cells. "Our next goal is to determine if there is some developm...

Hirsute Or Hairless? Two Proteins May Spell The Difference

...oteins were absent from 17.5-day-old knockout mice lacking TGF-β2 but not from their nonmutant littermates. C...splayed ectopic expression of Snail. Knockout mice lacking TGF-β2 also showed higher levels of E-cadherin—normally down-regulated by Snail—than their nonmutant...

Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries

...ago. In the current study, scientists exposed mice lacking AIM to a fatty diet that would normally induce atherosclerosis. After several weeks, researchers found little to no atherosclerotic lesions. Comparatively, in mice that had normal AIM function, there was marked presence of plaque deposits in the art...

Iron exporter revealed that may explain common human disorder

...lobally and in select tissues. Animals completely lacking ferroportin died early in development due to a fai...lity of cells to release iron once absorbed. Mice lacking ferroportin only in intestinal cells also developed severe iron deficiency anemia, further confirmin...

Nanoscale Diagnostic Sets Sights on Alzheimer's

...ke Alzheimer's where a reliable diagnostic tool is lacking and early intervention could have a significant impact on the lives of patients and their loved ones, in addition to lowering health care costs." ?Sohi Rastegar ...

Researchers identify protein crucial for survival of Lyme-disease bacterium

...eaks down whole blood. "For some reason, bacteria lacking the BptA protein either can't utilize the blood meal in the way the wild-type bacteria do, or something about the blood becomes hostile to them," said Dr. Norgard, who holds the B.B. Owen Distinguished Chair in Molecular Research. "Instead of helping...

Multi-purpose protein regulates new protein synthesis and immune cell development

...were missing the gene for IRE1. He found that mice lacking both copies of IRE1 died before birth and had fewer hematopoietic stem cells ?precursor cells which develop into many different types of blood and immune cells ?than normal mice. Zhang transplanted hematopoietic stem cells from IRE1 knock-out embryo...

Light therapy may combat fungal infections, new evidence suggests

...f another, distantly related fungus. Yeast strains lacking one of those genes, known as white collar 1 (BWC1)...earchers found, mice inoculated with C. neoformans lacking either of the light-sensing genes remained healthy 30 days later, while those infected with the norm...

Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis

...lations. The team also demonstrated that BM cells lacking Mcl-1 did not multiply when removed from mice and cultured in the laboratory. However, BM cells with the gene continued to flourish. In contrast, liver cells were unaffected following loss of Mcl-1, demonstrating that Mcl-1 is important only in certa...

Same-Sex Mating Discovered in a Toxic Fungus

... explained. Furthermore, the team showed, strains lacking components required for mating -- including pheromones, pheromone receptors and other genes with known roles in mating -- exhibited a defect in fruiting. The newly described mating strategy might allow a single mating strain to expand rapidly by cel...

Researchers unlock mechanism creating jigsaw puzzle-like plant cells

...ly over expressing one or the other leads to cells lacking the interlocking jigsaw puzzle appearance. While the researchers unlocked a fascinating mechanism of biochemical crosstalk that coordinates cells into tissues, a deeper understanding of how plant cells chemically talk to each other to grow or recede...

Brain-injury rehabilitation depends on acetylcholine circuitry

... deficit in their reaching ability, while the rats lacking a cholinergic system recovered only about 18%. In other experiments, the researchers compared the plasticity of brain reorganization in a brain region known to be "cholinergic independent" with the area governing forelimb control, which was "choline...

NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses

... the first part of the study, they found that mice lacking a p27 gene that were fed with a corn-oil rich diet...ock-out mice given a Western diet, full of fat and lacking calcium and vitamin D, formed the most number of tumors. The researchers then looked at the role th...

Of mice and men's (and women's) contraceptives

Mice lacking a special protein found only in germ-line cells results in infertility in both males and females, according to a new study from researchers at the University of Pennsylvania School of Medicine. Norman Hecht, PhD, Professor of Human Reproduction in Pe...

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