Tag: "lab" at biology news

NHGRI aims to make DNA sequencing faster, more cost effective

...ter, much too small to be seen with a conventional lab microscope. Several groups are developing nanopores (holes about 2 nanometers in diameter) for use as DNA sequence transducers and propose to detect an electrical, or ionic, signal from individual DNA molecules. The goal of this group is to fabricate...

New clues to how sex evolves

...d of each of the worm's six chromosome. Dernburg's lab has been studying the role of these special regions. Last year Dernburg, Phillips, and their colleagues identified the function of a C. elegans protein called HIM-8. This protein binds to and helps bring together copies of the worm's sex chromoso...

Transplanted photoreceptor precursor cells restore visual function in mice with retinal degeneration

...rs. Masayuki Akimoto and Hong Cheng in the Swaroop lab published an important study describing the "birth" of rod cells.* They were able to make this process visible by building on previous research, using an NRL gene regulatory element to tag the rods with a green fluorescent protein. This enabled Kello...

Common ancestry of bacterium and plants could be key to an effective new treatment for chlamydia

...k and Andre Hudson, a postdoc working in Leustek's lab in Rutgers' Biotechnology Center for Agriculture and the Environment, were able to solve the pathway when they discovered the gene encoding the enzyme L,L-diaminopimelate aminotransferase from the plant Arabdiopsis thaliana. The results of this disco...

'Failed' experiment yields a biocontrol agent that doesn't trigger antibiotic resistance

...ing over a failed experiment. A researcher in his lab had been trying to insert two different mutations ...gly in the potential of the basic work done in his lab that he, along with professor of oncology Richard Burgess, started a company called ConjuGon - "beca...

A buffet for early human relatives

...h.D. degree, "really made terrific advances in the lab to make this [study] possible," Cerling says. The laser was used to remove samples at various points along the length of the tooth, which is marked by tiny ridges called perikymata. They run parallel to the tooth's crown and represent tooth growt...

Brown scientists map structure of DNA-doctoring protein complex

...Nature, scientists working in the Brown University lab of Arthur Landy and the Harvard Medical School lab of Thomas Ellenberger announced they had solved the structure of "-integrase ("-Int), the protein "s...

Tracing the formation of long-term memory

...pecial laboratory techniques, he and others in the lab showed that they could block the calcium influx by blocking the function of a protein critical to making the new synapses associated with long-term memory....

RNA map provides first comprehensive understanding of alternative splicing

...lished in Science and Nature Genetics, the Darnell lab identified over 50 Nova-regulated alternatively spliced exons, using new techniques developed at Rockefeller specifically to find Nova RNA targets, and validating their results in "knockout" mice that were missing Nova. In the new study, Darnell, ...

A new approach to growing heart muscle

... approach or another, but the U-M team can use its lab to test multiple approaches at once. "Fundamentally, we're interested in creating models of the different components of the heart one by one," says Birla. "It's like building a house ?you need to build the separate pieces first. And once we unde...

Mysterious 'neural noise' actually primes brain for peak performance

... doctor reasons out a diagnosis, and right now our lab is pushing hard to find out exactly how that noise makes all these different aspects of being human possible." Pouget's work still has its skeptics, but this, his fourth paper in Nature Neuroscience on the topic, is starting to win converts. "If ...

American scientist's research of life's first cells

...DNA. As a graduate student in Phillip D. Zamore's lab at the University of Massachusetts Medical School ...ly a Jane Coffin Childs postdoctoral fellow in the lab of Erin K. O'Shea at Harvard University where she studies stress response in yeast. Bernhard L...

Fast-freeze snapshot yields new picture of nerve-muscle junction

...d with tiny, one-millimeter-long nematode worms, a lab animal widely studied by neuroscientists. Investigators report the finding in the Aug. 2 issue of the Journal of Neuroscience. Janet Richmond, associate professor of biological sciences at the University of Illinois at Chicago, is the corresponding ...

Detailed 3-D image catches a key regulator of neural stem cell differentiation in action

...tion gleaned from their structural studies, Noel's lab has already started that structure-based program. "We have designed the first generation of inhibitors and now it is a matter of chemically synthesizing them, testing them in test tubes and cells, and imaging them bound to Scp1 in 3D," says Noel. Thi...

Powerful genome ID method extended to humans

...hor Anton Valouev, a recent graduate of Waterman's lab and now a postdoctoral fellow at Stanford University, said the algorithm makes it possible to optically map the human genome. "It carries tremendous benefits for medical applications, specifically for finding genomic abnormalities," he said. Th...

Plants give up answers in the war on bacteria

...er plants. Last month, in Science Magazine, the lab outlined a better understanding of how bacteria se...n sense danger and respond by shutting down. The lab performed experiments on Arabadopsis, a common laboratory plant, but the mechanisms could be univers...

HIV gets a makeover

...Theodora Hatziioannou, a research scientist in the lab and the paper's first author, had to overcome two major obstacles: the first was a protein called TRIM5 that, in monkeys, recognizes the outer shell or "capsid" of HIV-1 but not that of SIV. By swapping out the capsid region of the HIV-1 genome for t...

Giant insects might reign if only there was more oxygen in the air

...ab. When the creature was discovered the next day, lab workers thought it had drowned. But when they removed its apparently lifeless little body from the water, they were surprised to see it crawl away. Tracheae grow disproportionately This experiment was designed to find out: how much room...

A new target for painkillers

... an incoming college freshman working in Olivera's lab in 1979, McIntosh discovered in cone snails the natural form of a drug now used against severe nerve pain. It is Prialt, which must be injected into fluid surrounding the spinal cord as a treatment for severe pain due to cancer, AIDS, injury, failed ...

Distinguishing friend from foe in the battle against cancer

...get for development of cancer drugs." The Hunter lab previously showed that mouse cells lacking tumor suppressors known as TSC genes are more susceptible to the lethal effects of chemotherapeutic agents than are normal cells. Why cells from these TSC null mice were so poorly equipped to survive was not...

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