GeneNotes - A novel information management software for biologists
... Tons of genes, tons of synonyms for each, tons of known interactions, with even more being unknown, tons of database with tons of information... and your job is to make sense of this puzzle in a biologically meaningfull way. Applications are being developped to make it all easier, leaving the fun part : b...Researchers find new genes necessary to make embryo
...terparts of four of the newly identified genes are known to be associated somehow with disease, and mutations in two of these are associated with tumors. The C. elegans study suggests specific cellular roles for these genes, thus providing important clues to how these genes work in humans. The new data al...Marburg haemorrhagic fever in Angola update
...e operational response began the following day. As known from extensive experience with outbreaks of other ...ds the mobile teams remains of concern in one area known to have recent cases and deaths. Efforts to sensitize affected communities are continuing, with loca...New insight into regulation of blood stem cells
...ng adult animals to examine the role of a key gene known to be required for blood cell formation. Informati...ntial therapeutic contexts. Blood cell formation, known as hematopoiesis, begins with a hematopoietic stem cell (HSC), which can either "self-renew" and mak...UCSD-Salk Team Show Protein’s Gene-Silencing Role In Development of Nervous System
...ied master gene complex called REST/NRSF, which is known to control neuronal genes. In their investigations with mice and fruit flies, the scientists found that REST/NRSF recruits SCPs only to neuronal genes. “These findings suggest a way to expand the pool of neuronal stem cells, which could lead to new...Birds brains reveal source of songs
...journal, Public Library of Science Biology. "We've known there are several brain areas involved: a motor circuit for producing the song, and a learning circuit, called the AFP (for anterior forebrain pathway), that sends its output to the motor system." Normally, the young zebra finch nursery resounds wit...Rare surgery performed to remove pancreas, prevent diabetes
In a 12-hour, dual-stage surgery known to be performed at only two other centers in the U...rovide relief. The pain of chronic pancreatitis is known to be constant and extremely debilitating. Facing a life of suffering from the condition, Stewart ch...Strongest proof yet found for prion hypothesis
...that the mysterious and devastating brain diseases known as "transmissible spongiform encephalopathies" (TSEs) are transmitted by an infectious agent composed only of a malformed protein, and not a virus. TSEs, which can afflict both human beings and animals, include mad cow disease, new-variant Creutzfeld...Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
...iking lateralization," Brown reported. "It is well known that speech is largely a left-sided cortical function. But our data indicate that lateralization also occurs in lower parts of the brain. Moreover, different kinds of rewards (in this case, the "rush" of romantic love, compared with the pleasing expe...Medical molecules designed to respond to visible light that can penetrate tissue
...e therapeutic window. Starting with a complex with known DNA cleaving qualities, they changed the light absorber unit to one that responds to the red wavelength. "Investigations into polyazine supermolecular complexes containing Ru and Os with Rh centers that possess photoactive MMCT states: Visible light...Reservoirs may accelerate the spread of invasive aquatic species, researchers say
...munities of stocked fish. An ecological hypothesis known as the fluctuating resource availability hypothesis suggests that these characteristics will enhance the susceptibility of reservoirs to invasion. Because reservoirs are more saline that freshwater lakes, Havel, Lee, and Vander Zanden propose they co...To control germs, scientists deploy tiny agents provocateurs
...xchanging small molecules and peptides - a process known as quorum sensing. Past a certain density threshold, the colonies unite to initiate group behaviors, such as biofilm formation. Attempting to manipulate quorum sensing in both plant and animal bacteria, Blackwell and her team are designing new compo...Solutions that reduce death of marine life reeled in by International Smart Gear Competition
... ensnared by fishing nets and longlines--a problem known as bycatch--while also improving the efficiency of commercial fishing. "These solutions safeguard our living oceans," said Carter Roberts, president and CEO-elect, World Wildlife Fund. "When World Wildlife Fund began the Smart Gear competition, we l...Brain-mapping technique aids understanding of sleep, wakefulness
...the upstream neurons in the anterior hypothalamus, known to be active only during sleep, send inhibitory signals to orexin neurons preventing them from releasing orexin. "Neurons producing orexin keep you awake, and they also stabilize wakefulness," Dr. Yanagisawa said. "In order to fall sleep, you someho...Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis
...rate more specific cells, such as the immune cells known as B and T lymphocytes. In the Science study, Opferman's team genetically modified mice so that the gene for Mcl-1 could be specifically deleted from the genome of HSCs and progenitor cells. Upon genetic deletion, these mice developed anemia and had...Revolutionary nanotechnology illuminates brain cells at work
... the chemical, which is then visible via a process known as fluorescence resonance energy transfer, or FRET. In a new study, the nanosensors were introduced into nerve cells to measure the release of the neurotransmitter glutamate--the major brain chemical that increases nerve-cell activity in mammalian br......ed to the identification of a family of receptors, known as HER, that sit antenna-like on the outside of the cell wall and are implicated in certain types of cancer. A team of researchers under Prof. Yosef Yarden, Dean of the Weizmann Institute's Feinberg Graduate School and a professor in the Institute's ...Discovery may lead to better Candidiasis drug
...sion being held in Baltimore. Candidiasis also is known as thrush, a disease characterized by whitish spots and ulcers on the membranes of the mouth, tongue and throat. It affects primarily people with weakened immune systems caused by antibiotics, chemotherapy or by diseases such as AIDS. Thrush also aff...Sickle cell and protection against malaria
... young children in sub-Saharan Africa. It has been known for many years that in those areas most afflicted by malaria the gene for sickle cell hemoglobin (HbS) occurs very frequently. The protection against malaria occurs in people who are heterozygote (HbAS), i.e., have one normal and one sickle gene, and...... that plants cannot consume is nitrous oxide, also known as laughing gas. In the atmosphere, nitrous oxide is 310 times more potent as a greenhouse gas than carbon dioxide. Thus, as very large phytoplankton blooms deplete more oxygen from the water, the creation of nitrous oxide in the Arabian Sea could ex...