Chemists identify key gene in development of type 1 diabetes
...y role in the development of type 1 diabetes, also known as insulin-dependent or juvenile diabetes, a disea...is much less common than type 2 diabetes, formerly known as adult onset or non-insulin-dependent diabetes, which is often associated with obesity. "We've sh...International HapMap consortium expands mapping effort
...f common patterns of human genetic variation, also known as haplotypes. By the end of February 2005, howeve...l expand that effort and test virtually the entire known catalog of human variation on the HapMap samples. This will increase the density of SNP "signposts" ...Bone Density Recovers After Teens Stop Injected Contraceptive
... progestin, some contain only progestin. It is not known whether oral contraceptive use affects bone mineral density and NICHD is currently supporting a study to address this issue. The researchers measured the participants?bone mineral densities when the study began, and every six months thereafter for t...Breast-Cancer Risk Linked to Exposure to Traffic Emissions at Menarche, First Birth
...ffic PAHs, using measurements of benzo[a]pyrene, a known potent mutagen and carcinogen, as a surrogate for total PAH exposure. Cruise emissions, cold engine emissions and intersection emissions were used to estimate total traffic PAH emissions. In addition, meteorological information was used in a geograp...Towards precise classification of cancers based on robust gene functional expression profiles
...y role in the development of type 1 diabetes, also known as insulin-dependent or juvenile diabetes, a disea...is much less common than type 2 diabetes, formerly known as adult onset or non-insulin-dependent diabetes, which is often associated with obesity. "We've sh...Antibiotic might fight HIV-induced neurological problems
...from HIV or SIV, attracts infection-fighting cells known as macrophages, which then enter the brain. The in...ese cells contributes to swelling and inflammation known as encephalitis. The other protein, p38, helps trigger a series of events that result in a cell's pr...Researchers develop rapid diagnostic tool for pathogen identification
...ostics, researchers built on an established method known as polymerase chain reaction that allows amplifica...netic probes for pathogens were coupled to markers known as mass codes. After amplification, incorporated mass codes were detected by mass spectroscopy allow...Protein offers way to stop microscopic parasites in their tracks
... slow cell invasion by malaria and other parasites known as apicomplexans. Results of the study will appea...en their lack of appendages or hairlike structures known as cilia or flagella. Researchers had determined that Toxoplasma has a rotating protein-based convey...Asthma gene clusters identified
...sthma, but this is the first time that clusters of known genes have been identified as being activated in acute forms of childhood asthma. Dr. Hershey said the findings open the door to the possibility of developing treatments based on the unique genetic profile of patients. For example, specific therapie...Artifical cornea lets woman blind 20 years see
...naged to refine a type of artificial cornea widely known as the Boston keratoprosthesis. He has made more than 300 of the devices himself, but holds no financial interest in the success of the artificial cornea. "We've been fortunate to see gradual improvement in the use of the keratoprosthesis over the y...Use of Insecticides Linked to Lasting Neurological Problems for Farmers
... are no longer available commercially. DDT, a well known example of an organochlorine, has been banned for use in the US since 1972. Organophosphates, such as malathion, chlorypyrifos, and diazinon, have been banned or restricted for home and garden use in the US. However, some of the pesticides examined, ...LUCA technologies confirms real-time methane generation
...sortium. Clostridia form a broad genus of bacteria known for their diverse metabolic pathways. Clostridia f...ive in anaerobic environments and many species are known for their heat tolerance. Thermatoga microorganisms are known to play a role in the anaerobic oxidat...Pathogen-Mimicking Vaccine As Strategy For Cancer Therapy
...peptide (protein fragment) from a melanoma antigen known as Melan-A/MART-1, induced CD8+ T cells that specifically recognized cells displaying Melan-A/MART-1 on their surface. This T cell response occurred in all eight patients in the trial. Responses were one order of magnitude higher than those observed ...Vampire bats keep out of trouble by running
...ording to a recent Cornell University study. It's known that the common vampire bats of Central and South ...ur. Although many of the 1,100 species of bats are known to walk, the common vampire is the only one so far to pass Riskin and Hermanson's treadmill test and...Surprising findings reported about iron overload
...is. At the beginning of the study in 2000, it was known that most cases of hemochromatosis in Caucasians r...first discovered in 1996. At that time, little was known about the causes of iron overload in other racial/ethnic groups. Major findings of the study includ...Variation in women's X chromosomes may explain differences among individuals, between sexes
...le's X chromosome are switched off, a modification known as X inactivation. Originally, scientists had ass...ding to the researchers. For one thing, women are known to consist of a mosaic of two cell types that differ in which X chromosome is inactivated. The Y chr...World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics
...ersity of Alberta and Capital Health surgeon, well known for his pioneering work in developing the Edmonton Protocol treatment for diabetes, has taken another important step in the fight against diabetes. On January 19, at Kyoto University Hospital, Dr. Koichi Tanaka and Dr. James Shapiro, along with a te...Hirsute Or Hairless? Two Proteins May Spell The Difference
...and colleagues explored several signaling proteins known to be involved in bud formation as possible activators of Snail expression. When the authors treated keratinocytes with small amounts of one stimulator, TGF-β2, they saw “rapid and transient induction of Snail.?Snail proteins were absent from 17.5-da...Programmable cells: Engineer turns bacteria into living computers
... important proof-of-principle in an emerging field known as "synthetic biology," which aims to harness living cells as workhorses that detect hazards, build structures or repair tissues and organs within the body. "We are really moving beyond the ability to program individual cells to programming a large ...UCLA launches $20 million stem cell institute to investigate HIV, cancer and neurological disorders
...ancer stem cells and how they develop. Not much is known about cancer stem cells and new findings may lead to therapies that target cell signaling pathways specific for cancer stem cells. These therapies hone in on what is broken in a cancer cell while leaving the healthy tissue intact. Several Jonsson Can...