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Tag: "knocking" at biology news

Mutating the entire genome

...y to do that.” The new method is “a cheaper way of knocking out a gene as well as regulatory sequences.” C...ed 20,000 mouse genes would cost $200 million, and knocking out the roughly 300,000 non-gene DNA sequences in mice would cost $3 billion, he adds. The new m...

RNA splicing factor implicated in ovarian tumor cell growth

...research assistant professor Xiaolong He show that knocking down PTB expression with small, interfering RNA "substantially impairs ovarian tumor cell growth, colony formation and invasiveness." The research has been published in the online version of the journal Oncogene; it will appear in an upcoming issu...

A genetic 'gang of 4' drives spread of breast cancer

...blood vessel structure in the tumors revealed that knocking down all four genes greatly reduced growth of the tangle of blood vessels typically seen in tumors. Further experiments revealed that the tumor blood vessels that did form allowed fewer cancer cells to escape into circulation. The researchers next ...

New molecular pathway could reveal how cells stick together

... protein. She has previously done similar work knocking out MMP in flies. "One of the defects in MMP mutants is in their ability to control cell adhesion," she said. Many tissues undergo remodeling as the flies grow and develop, but at least one, the breathing tubes, do not develop properly in the mutant ...

Knocking out survival protein could aid leukemia treatment

... the cells to self-destruct. "We've shown that knocking down Mcl1 can, by itself, cause CLL cells to die, and that this effect might enhance the activity of rituximab," says first author Rehan Hussain, a postdoctoral fellow with Ohio State's Comprehensive Cancer Center. Byrd, Hussain and their collabo...

Minuscule molecules pack a powerful punch

...the Wellcome Trust Sanger Institute. "Showing that knocking out a microRNA has such dramatic effects opens new doors to understanding this novel class of gene regulation, with consequences for human health and disease. "Our work builds upon the sequences of the human and mouse genomes, the power of comput...

St. Jude announces breakthrough in eye cancer treatment

... called MDM2 in adult cancer cells. The success in knocking out MDMX with nutlin-3 represents the first exampl...ntities of MDMX in the cells," Dyer explained. "So knocking out MDMX in those cancers might also dramatically reduce tumor size. And administering the drug dire...

Knockout Mouse Project

...of understanding the pathology of human genes. By knocking out each gene one-by-one, we will be able to create a central resource for researchers and scientists to use and study," said Dr. de Jong. Children's Hospital Oakland Research Institute has a recombinant DNA library with more than 30 million DNA sam...

Plant-derived molecules, genetic manipulation point to future chemoprevention methods

...ted with a significant challenge, in that directly knocking out expression of IGF-1 in mice resulted in severe developmental abnormalities and very low survival rates. Therefore, the researchers found an existing type of mouse that lacked a gene called igf1 in the liver. These mice are IGF-1 deficient, but de...

Leading reason for corneal transplants comes into focus

...ulprit genes," says Gottsch. "Now we have to start knocking on every door." Gottsch is heartened by success with earlier Fuchs gene-hunting studies. The Hopkins group tracked down its first FCD-related gene in a Virginia family with multiple, early onset cases. That gene, labeled COL8A2, was mapped to chro...

Proteins anchor memories in our brain

...cal School, and colleagues there demonstrated that knocking out the Aire gene in the mouse thymus led to failures of expression of a number of genes in peripheral tissues, resulting in autoimmune diseases in those tissues -- the first direct evidence linking gene knockouts in the thymus to autoimmune defects ...

Autoimmune disease triggered if T cells miss a single protein early on

...cal School, and colleagues there demonstrated that knocking out the Aire gene in the mouse thymus led to failures of expression of a number of genes in peripheral tissues, resulting in autoimmune diseases in those tissues -- the first direct evidence linking gene knockouts in the thymus to autoimmune defects ...

Enzyme shreds Alzheimer's protein

...rotein "garbage deposal" system. They found that knocking out the CatB gene increased plaque deposition in a mouse model of AD in which mice expressed the human form of APP. They also found that CatB tended to accumulate within amyloid plaques and that it acted to reduce Aß levels in neurons. And they found...

Researchers find protein that silences genes

...leolar dominance. In this process they found that knocking down HDA6 eliminated nucleolar dominance, such that the normally silent genes were now turned on. To find out where HDA6 is located in the cell, the group then genetically engineered the protein to include a fluorescent tag and found that much of t...

Interfering RNA silences genes in 'slippery' immune cells

...ent. "The siRNA may represent a suicide vector: by knocking down HALP it may allow HIV-infected cells to self-destruct, thus eliminating a hiding place for the virus," said Dr. Finkel. "More broadly," she added, "the technique could theoretically be directed against other immune-related diseases, by silenc...

Johns hopkins researchers find link between cell's energy use and genome health

... scientists at Johns Hopkins got busy alternately knocking out two catalysts vital to managing a yeast cell's energy. They discovered to their complete surprise that the removal of one of them led the cell to turn off 70 percent of its 5,000 genes and die. "We were completely unprepared for such a dramatic...

African parasite makes component of fat differently from all other organisms

...imals and plants. The researchers reasoned that knocking out the fatty acid-making genes would prevent the parasite from making myristate and other fatty acids. But when one member of the research team, Jennifer Stephens, knocked out a single gene in the trypanosome known to make fatty acids in other or...

USC researchers investigate protein that protects tumors

...therapy would be to block the protein, essentially knocking out one of the tumor cell's guardians. A similar approach was used to develop Herceptin, one of the first biological treatments for breast cancer. Herceptin targets the her2 protein, which is found on the surface of tumor cells about 20 percent of th...

Flesh-eating bacteria escape body's safety net

...ed a molecular genetic approach for their studies, knocking out the gene encoding the DNA-degrading enzyme from a pathogenic Strep strain that was originally isolated from a patient suffering from necrotizing fasciitis. "Deprived of this single enzyme, the mutant Strep strain was easily killed by human neutr...

Texas scientists discover how a hepatitis C protein promotes liver cancer

...ty to control cell proliferation," Lemon said. "By knocking out this 'tumor suppressor' and promoting the proliferation of liver cells, this viral protein is setting up the liver for cancer." According to the federal Centers for Disease Control and Prevention, about 85 percent of liver cancer cases in the Un...

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