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Tag: "kinase" at biology news

Novel Enzyme Shows Potential As An Anti-HIV Target

...AR requires recruiting the enzyme cyclin-dependent kinase 9 (CDK-9) to the HIV promoter (where transcription begins). CDK-9 chemically modifies the RNA polymerase and enhances its transcribing efficiency. The transcription process—including the labyrinthine protein–protein and protein–DNA (and in the case ...

Clam embryo study shows pollutant mixture adversely affects nerve cell development

...roduction of a subunit of an enzyme called protein kinase A (PKA),which previous research suggests plays a role in neural development,"says Reinisch. "Fluctuations in PKA may influence not only neuronalmaturation but also how neuronal networks are constructed duringdevelopment," she says. Alterations of thi...

Study identifies predictors of HIV drug resistance in patients beginning triple therapy

...roduction of a subunit of an enzyme called protein kinase A (PKA),which previous research suggests plays a role in neural development,"says Reinisch. "Fluctuations in PKA may influence not only neuronalmaturation but also how neuronal networks are constructed duringdevelopment," she says. Alterations of thi...

Breast Cancer May Be 'Uniquely Sensitive' To Inhibitors Of PI3K Pathway

...about the importance of the phosphatidylinositol 3 kinase (PI3K)pathway to breast cancer development, says Gordon Mills, M.D., Ph.D., aprofessor and chair of the Department of Molecular Therapeutics. Thispathway, which is linked to critical growth factor receptors and isinvolved in programmed cell death, is...

Genetic Variation Visualization - From EMBL

...about the importance of the phosphatidylinositol 3 kinase (PI3K)pathway to breast cancer development, says Gordon Mills, M.D., Ph.D., aprofessor and chair of the Department of Molecular Therapeutics. Thispathway, which is linked to critical growth factor receptors and isinvolved in programmed cell death, is...

New Mixing Method for Microchip-Sized Labs

...about the importance of the phosphatidylinositol 3 kinase (PI3K)pathway to breast cancer development, says Gordon Mills, M.D., Ph.D., aprofessor and chair of the Department of Molecular Therapeutics. Thispathway, which is linked to critical growth factor receptors and isinvolved in programmed cell death, is...

Key Trigger Of Opioid Withdrawal Symptoms Found

... discovered that a molecular switch called protein kinase A was part of the triggering machinery involved in...it either the GABA transporter activity or protein kinase A eliminate the hyperexcitability of the PAG neurons in the mouse brain slices. The researchers cit...

Special Imaging Study Shows Failing Hearts Are 'Energy Starved'

...al that fuels heart contractions and that creatine kinase (CK) is the enzyme for one of the sources of ATP, we believe this is the first time someone has actually measured the flux of ATP produced by CK reaction in the beating human heart.?/p> Specifically, Bottomley and a team of cardiologists and radi...

Scientists identify molecule that regulates well-known tumor suppressor

...t for cancer therapy. The phosphatidylinositol 3' kinase signaling pathway regulates cell growth and survival, and is inhibited by activity of the tumor suppressor PTEN. Research indicates that PTEN exerts its tumor suppressor activity by inhibiting PKB/Akt signaling that is critical for cell survival. Man...

New understanding of DNA repair may pave way to cancer treatments

...Transcription Factor-2") is activated by a protein kinase called ATM ("Ataxia-Telangiectasia Mutated), which stimulates DNA repair. ATF2's role in regulating expression of proteins that control cell cycle and programmed cell death is well established. The current study is the first to demonstrate ATF2's rol...

New tumor-suppressor gene discovered

...in product of the mats gene could partner with the kinase product of a known tumor-suppressor gene named "wts," which turned out to be the case. The researchers performed three experiments to test whether the mats and wts genes interact genetically. In the first experiment, they inserted an additional norm...

Building a human kinase gene repository

...t the sequence information of all identified human kinase genes and have built a gene repository for this gene class. Their work is described in the online early edition of Proceedings of the National Academy of Sciences and demonstrates uses of the collection in cellular and biochemical assays. Kinases ar...

Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol

...ctivity of several members of the cyclin-dependent kinase (CDK) family of enzymes, which are the triggering molecules that allow a cell to grow and divide. CDK cell cycle enzymes are the end target of numerous cellular pathways that are involved in cancer development and progression, the researchers say. B...

Microarrays as phenotype

...a particular pathway in that organism. The protein kinase A (PKA) signaling pathway occurs when the organism encounters starvation. The pathway enables the single cells to combine into a multi-cell organism. "We pretended we did not know the order of genes in the pathway," said Shaulsky. "We were able to r...

Researchers Identify Cause of Early Bird Sleep Disorder

... the change causes a protein -- an enzyme called a kinase that is made by the gene - to be less active than normal. The lead author of the paper in Nature is Ying Xu, a member of the team in San Francisco. Other team members are at the University of Vermont and the University of Utah. ...

Montreal researchers probe the genetic basis of memory

...campal synaptic plasticity and memory by the eIF2a kinase GCN2, which was published in the August 25th issue of the journal Nature, provides the first genetic evidence that protein synthesis is critical for the regulation of memory formation. This new discovery is the fruit of an international collaborati...

Engineered skin offers clues to melanoma development

... Ras and hTERT, the expression of cyclin-dependent kinase 4 (CDK4),which promotes cell growth and inhibits Rb function, induced invasive melanoma in human tissue. Similarly, inhibition of p53, when combined with Ras and hTERT, resulted in invasive melanoma. The scientists also investigated the role of elev...

Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack

... Ras and hTERT, the expression of cyclin-dependent kinase 4 (CDK4),which promotes cell growth and inhibits Rb function, induced invasive melanoma in human tissue. Similarly, inhibition of p53, when combined with Ras and hTERT, resulted in invasive melanoma. The scientists also investigated the role of elev...

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

... Ras and hTERT, the expression of cyclin-dependent kinase 4 (CDK4),which promotes cell growth and inhibits Rb function, induced invasive melanoma in human tissue. Similarly, inhibition of p53, when combined with Ras and hTERT, resulted in invasive melanoma. The scientists also investigated the role of elev...

Energy management in cells may hold key to cancer defense

...emonstrated that cells lacking a tumor-suppressing kinase called LKB1 can still maintain healthy energy leve... focused much of his research on the AMP-activated kinase (AMPK) which responsible for managing energy within cellular pathways. "A cell's energy level is c...

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