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Tag: "kidney" at biology news

Proteins may predict lung transplant rejection

...fects, including an increased chance of developing kidney disease or malignancies.) Finally, these findings could be used to understand the physiological mechanisms that lead to lung rejection, Wendt explained. Her team has developed two mouse models to determine whether these proteins play a role in the...

Clues to gene expression in cystic fibrosis will guide research

... side effects for some patients, including ear and kidney damage. The authors suggest that other drugs, such as amikacin or PTC124, with a comparable mode of action and fewer side effects, may have treatment potential. The in vitro method used to predict the trial’s outcome could be a first step to develop...

Cryoablation -- A new treatment option for some kidney tumor patients

Mayo Clinic researchers report that freezing kidney tumors through percutaneous cryoablation shows pro...’s issue of Radiology. The standard treatment for kidney tumors is surgery, providing a high likelihood of a long-term cure. For some patients, surgery is n...

Magnetic system could be key to surgery without scars

..., surgeons have been able to successfully remove a kidney using the Magnetic Anchoring and Guidance System. While working on the system, Dr. Daniel Scott, assistant professor of surgery, joined UT Southwestern as director of the Southwestern Center for Minimally Invasive Surgery. He said the technology ...

A healthier start to a pig's life

...been found by using a lectin obtained from the red kidney bean plant. Lectins are proteins with the ability to bind cells together; typically red blood cells. The EUREKA Healthy Weaning project coordinator, Professor Stefan Pierzynowski of Lund University, Sweden, explains: "Giving this factor, which we cal...

Speeding 'fingertip' discovery -- 20 years of protein info in 1 place

...rylation that was out there.? Working with human kidney cells, the researchers fished out the thousands of different proteins and analyzed them by ETD, resulting in a net total of 1,435 phosphorylations. Comparing these 1,435 to the 20 years?of published data, they discovered that about 80 percent of what...

Primitive yeast yields secrets of human cholesterol and drug metabolism

...r database and repeated their experiments in human kidney cells engineered to lack the human version of Dap1. As in yeast, the altered human cells accumulated cholesterol precursors and died because cholesterol is essential for cell survival. To show that Dap1 directly works with P450s and not through so...

Active ingredient in common Chinese herb shown to reduce hypertension

...treated, it can lead to heart attacks, strokes, or kidney disease. Lifestyle changes are the first-stage treatment for the disease, but if they fail, medications are prescribed. Many patients with high blood pressure have sought relief from complementary and alternative medicine (CAM). In so doing, man...

Discovery of an HIV inhibitor in human blood points to new drug class

...n filtered from the blood of patients with chronic kidney failure during dialysis, in search of those with anti-HIV activity. After sorting the more than one million blood peptides into 300 fractions, they focused on one that blocked HIV without toxic effects on cells. Further examination revealed VIRIP ...

Twin studies reveal genetic components leading to cardiac and kidney disease

... unexpected ways. "Factors linked to cardiac or kidney disease ?such as hypertension, a tendency toward o...ion of the protein albumin in urine is one sign of kidney disease, which can be a complication of diabetes. "Normally kidneys filter the blood to rid the ...

Putting an old drug to a new use

... cell or by binding directly to DMT-1 in liver and kidney still needs to be determined. "Understanding the exact molecular mechanism underlying nifedipine's effect on iron transport would be a big step towards developing it into an effective therapy that can be used on patients," says Martina Muckenthale...

Antibody therapy prevents type 1 diabetes in mice

...evels of sugar in the blood, leading to blindness, kidney failure, heart disease and nerve damage. Previously known as juvenile diabetes, type 1 diabetes is usually diagnosed at a very early age, but in some cases it can be diagnosed in adulthood. In this study, the Pitt researchers treated non-obese diab...

New mechanism for nutrient uptake discovered

...tential—from understanding human diseases, such as kidney function, to engineering better crops. "Every cell in every organism has a system for bringing in nutrition and expelling waste," explained lead author Dominique Loqué. "Some are through pore-like protein structures called transporters, which reside...

Arsenic in chicken feed may pose health risks to humans, C&EN reports

...c. Arsenic has been linked to bladder, lung, skin, kidney and colon cancer, while low-level exposures can lead to partial paralysis and diabetes, the article notes. Use of roxarsone has become a topic of increasing controversy. A growing number of food suppliers have stopped using the compound, includin...

Researchers from the University of Navarra analyze new kinds of cancer-fighting antibodies

...eatment is being tested in patients with melanoma, kidney and ovarian cancer because there are more ways of measuring the response of the immune system, but he expects to be able to expand this to include other forms of cancer. Five cancer-fighting agents being tested The first cancer-fighting agen...

Simple home spit test to spot deadly pre-eclampsia

... levels of which are thought to be due to impaired kidney excretion in pre-eclampsia. 'A salivary urate test is simple, non-invasive, quick and cheap and can be done at any time. As a metabolic test independent of blood pressure, it may obviate the need for hospital admission,' said retired hospital rheu...

Machine preservation may promote more organ sharing

...e purpose of this study was to compare outcomes in kidney transplant patients receiving kidneys from older d...which is produced by muscle, are used to determine kidney function. The current study included 120 ECD kidney transplants -- 95 kidneys were preserved wit...

Runners -- Let thirst be your guide

...rete. The hormone that determines how much fluid a kidney can excrete is arginine vasopressin (AVP), which i...ro when sufficient fluids are ingested so that the kidney can excrete, rather than retain, excess water. But AVP levels can rise in people who exercise strenu...

University of Pittsburgh School of Medicine researchers develop 'off-the-shelf' vascular grafts

...ficant implications for the treatment of heart and kidney diseases, where there is a critical need for new sources of blood vessels for vascular grafts. The saphenous vein taken from a patient’s leg continues to be the most commonly used graft for coronary artery bypass grafting even though a significant p...

Researchers shed light on mechanism of action used by anti-cancer drug

...ts with renal cell cancer, the most common form of kidney cancer in adults. It was originally developed as an inhibitor of the oncogene, Raf, which is frequently mutated in numerous cancers, including leukemia. Oncogenes are typically responsible for promoting tumor growth. Previous findings by Grant’s t...

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