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Tag: "key" at biology news

Key mechanism in genetic inheritance during cell division identified

A key mechanism in the passing of genetic material from a parent cell to daughter cells appears to have been identified by a team of Berkeley researchers. Their study may explain how a complex of proteins, called kinetochores, can recognize and stay attach...

Single stem cells from bone heal a broken heart

...eart cells and formation of new blood vessels ?two key components of successful myocardial repair. The results provide a foundation on which new approaches to repair the damaged heart can be based. Related : Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium aft...

Affymetrix Licenses Microfluidics Technology From Caliper Life Sciences

...ant to our corporate ideals and to our future as a key technology provider to the industry." The scope of the license agreement includes nucleic acids processing and handling associated with GeneChip arrays, but excludes the right to use LabChip technology with respect to products intended primarily to ...

New insight into regulation of blood stem cells

...es by using adult animals to examine the role of a key gene known to be required for blood cell formation...tion in check. These data suggest that c-Myb is a key regulator of hematopoiesis and acts at many distinct points to control HSCs. "It is remarkable that ...

UCSD-Salk Team Show Protein’s Gene-Silencing Role In Development of Nervous System

...hat a group of proteins called phosphatases play a key role in the development of the nervous system, has been shown in fruit flies and mice by researchers at the University of California, San Diego (UCSD) School of Medicine, in collaboration with scientists at the Salk Institute, La Jolla, California. T...

New drug shows promise as powerful anticancer agent

... clinical trials. Plk1 is a molecule that plays a key role in driving cell division. High levels of Plk1 have been observed in many human tumors, and studies using various laboratory techniques have shown that inhibition of Plk1activity leads to cell death. "Because all signaling pathways that have gone...

Harmful chemicals may reprogram gene response to estrogen

...the growth of tumors by regulating the activity of key genes involved in cell growth. "We found that the DES treatment somehow 'reprogrammed' how these genes respond to estrogen, making them much more responsive to estrogen than normal," said Walker. "We realized that the DES exposure enabled estrogen to...

Brain-mapping technique aids understanding of sleep, wakefulness

...exy. Because orexin-producing neurons play such a key role in regulating sleep, determining how they are connected to other neurons in the brain is an important step toward understanding how and why we sleep. Mapping the neurons to which orexin neurons send signals has been relatively easy, Dr. Yanagis...

Researchers report new pro-inflammatory role for anti-inflammatory enzyme

...endothelium and the NO that it synthesizes plays a key role in regulation of blood pressure, platelet aggregation, the reactivity of immune cells and growth of vascular smooth muscle cells," explains Dr. Hobbs. "iNOS is not expressed under normal physiological conditions, but is up-regulated for host-def...

Small species back-up giant marsupial climate change extinction claim

... amazing fossil deposits are providing us with the key to understanding Australia's past, something integral when developing long term strategies for a sustainable future." ...

Growth in biomass could put US on road to energy independence

...ch potential remains. "Our report answers several key questions," said Bob Perlack, a member of ORNL's Environmental Sciences Division and a co-author of the report. "We wanted to know how large a role biomass could play, whether the United States has the land resources and whether such a plan would be ...

Yeast Network Prevents Damage By Oxygen Radicals

...itute for Cancer Research (LICR) have identified a key network of DNA repair and cell cycle control genes in yeast that prevents the deleterious effects of ROS. "DNA repair and cell cycle control mechanisms are important guardians against cancerous changes in human cells," says Dr. Richard Kolodner, LIC...

Human Cells Filmed Instantly Messaging for First Time

...ch potential remains. "Our report answers several key questions," said Bob Perlack, a member of ORNL's Environmental Sciences Division and a co-author of the report. "We wanted to know how large a role biomass could play, whether the United States has the land resources and whether such a plan would be ...

White Blood Cell 'Waste Disposal' System Plays Critical Regulatory Role

...dy identifies a critical inhibitory step that is a key component of the feedback circuit regulating the balance between neutrophil production and destruction. The research, published in the March issue of Immunity, suggests that the process for disposal of dying neutrophils is actively linked to neutroph...

Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells

...rmally have only weak anti-leukemic activity. The key breakthroughs made by the St. Jude team were the development of a laboratory technique for rapidly producing a large, pure population of NK cells from a small sample of blood; and developing a technique for genetically modifying NK cells so that they...

Some Brain Cells 'Change Channels' To Fine-tune The Message

...g ability has been recognized for a few years, the key players controlling it hadn't been identified. Now, by studying mice, the Hopkins team has identified two proteins, called PICK1 and NSF for short, that help replace channels that let charged calcium ions in with another kind of channel that keeps ca...

Genetic defects give the immune system the green light to attack the pancreas

...e genetic stage is set beforehand. T-cells play a key role. They are part of the highly complex array of immune cells that normally work together to fight invaders such as bacteria or viruses, adapting specifically to each new invader. Formed in the thymus gland, T-cells begin as “precursor?cells and ma...

Leprosy microbes lead scientists to immune discovery

... the monocytes hadn't succeeded in producing those key anti-bacterial fighters. "The logic here is that because their monocytes are unable to produce the [CD1b+] cells that can mobilize T-cells, these people don't respond well and become much sicker," commented Bloom. "This research gives us insights ab...

Used in a new way, RNA interference permanently silences key breast cancer gene

... gene is believed to interfere with the ability of key immune cells to attack a growing tumor. Investigators used the lentivirus to permanently insert the RNAi into the genome of the cancer cell. After a single exposure of this delivery system, they found 75 percent of laboratory breast cancer cells sto...

Different microarray systems more alike than previously thought

...e. "Technical choice of microarray platforms is a key issue for people who want to look at changes in gene expression. It is important for both cost and quality of data," she said. "But people are in need of clear information in making the choice." For the study, five expert labs used Affymetrix GeneCh...

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