key 2 1

Tag: "key" at biology news

A gene's first 'kiss' sets off that affair known as puberty

...isspeptin protein molecule produced by KiSS-1, are key to the initiation of puberty, when GnRH is released," Dr. Plant said. "However, it's unlikely that they act alone. Other signaling systems, some of which have probably yet to be identified in humans, help control GnRH release in primates." Besides l...

Man and mouse share genome structures

... This regulatory structure, called chromatin, is a key regulator of gene expression in healthy and diseas...ions of genome containing the HOX genes, which are key regulators of development. "In most of the genome, we see short stretches associated with activated...

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...ese important parts of the mechanism activate many key genes of lipid biosynthesis involving the pathways of cholesterol and triglycerides; these genes directed the liver to manufacture more cholesterol, which it does in the form of very low-density lipoproteins. The investigators noted that in mice fed ...

Spleen may be source of versatile stem cells

...n these cells. In mammals,Hox11 is a controller of key steps in embryonic development - includingthe formation of the spleen - but it was not known to be present inadults under normal circumstances. In some other animals, however, theprotein has an intriguing function: when creatures like newtsregenerate...

University of Manchester makes made-to-measure skin and bones a reality using inkjet printers

..., it would beimpossible," Professor Derby says.The key to the advance which Professor Derby and his team have made isthe innovative way in which they are able to pre-determine the size andshape of the tissue or bone grown.Using the printers, they are able create 3-dimensional structures,known as 'tissue ...

W.M. Keck Foundation funds study of friendly microbes

...teria." "Fortunately, these microbes endow us with key metabolic functions that we have not had to evolve...to funding high-risk projects designed to overcome key obstacles in emerging fields in science so that rapid progress can subsequently be made," Gordon say...

Growth in the sea comes down to a struggle for iron

...that built the molecule in the first place has the key to unlock it, says Wells. "It's basically chemica...ase it, it binds iron, and then only they have the key to unlock it and get the iron out of it. "Now in reality it's warfare. In some cases other bacteria ...

New, automated tool successfully classifies and relates proteins in unprecedented way

...dwithout error," Murphy said.Murphy's tool has two key components. One is a set of subcellularlocation features (SLFs) that describe a protein's location in a cellimage. SLFs measure both simple and complex aspects of proteins, suchas shape, texture, edge qualities and contrast against backgroundfeatures...

New binding target for oncogenic viral protein

...ch ubiquitin. The proteins recognized by Fbw7 play key roles in cell division, cell growth, differentiation, and cell death. "These proteins are also some of the most broadly acting cellular oncogenes, and include cyclin E, c-Myc, Notch, and c-Jun," noted Dr. Clurman. "When Fbw7 is mutated in cancers, d...

Lack of enzyme turns fat cells into fat burners

...y maintenance," said Wakil. "ACC2 is potentially a key enzyme inthe regulation of weight, obesity, and related problems."Wakil and his colleagues studied the oxidation of fatty acid andglucose in cultures of fat cells isolated from both normal and mutantmice that lacked ACC2. When the mice were fed a nor...

Fox Chase Cancer Center scientists identify immune-system mutation

...ore directly. "The maturation of T cells involves key branch points at which cells choose one of two different pathways, going on to become helper cells or killer cells," Kappes said. His goal is to understand how T cells specialize to do different jobs. Commitment to the helper or killer lineages corr...

Neuronal 'traffic jam' marks early Alzheimer's disease

...had observed that overexpression of the gene for a key protein that underlies Alzheimer's pathology, call...in the mice and humans by reducing the levels of a key transport protein, kinesin-1, the cell's principal molecular motor for transporting proteins. "We ma...

Elusive HIV shape change revealed; Key clue to how virus infects cells

...Boston and Harvard Medical School have shown how a key part of the human immunodeficiency virus (HIV) changes shape, triggering other changes that allow the AIDS virus to enter and infect cells. Their findings, published in the Feb. 24 issue of the journal Nature, offer clues that will help guide vaccine...

Mouse brain cells rapidly recover after Alzheimer's plaques are cleared

...e in St. Louisinjected mice with an antibody for a key component of brain plaques,the amyloid beta (Abeta... research instructor, began theexperiment with one key question: how did clearance of brain plaques,made possible by the development of Abeta antibodies, a...

Key molecule in plant photo-protection identified

...e in St. Louisinjected mice with an antibody for a key component of brain plaques,the amyloid beta (Abeta... research instructor, began theexperiment with one key question: how did clearance of brain plaques,made possible by the development of Abeta antibodies, a...

Research advances quest for HIV-1 vaccine

...f the virus. The gp41 protein is thought to play a key role in mediating entry of HIV-1 into human cells. A research group led by Drs. Dennis R. Burton and Ian A. Wilson from The Scripps Research Institute in La Jolla, California performed a study examining the detailed molecular structure of the comple...

Novel antiviral technology inhibits RSV infection in mice

...erence, or gene silencing, to knock out one of the key proteinsneeded for RSV to multiply in the lungs. The virus harnesses thisprotein, known as NS1, to block the body's own antiviral response,which would normally kill RSV before it could gain a foothold."This is an exciting advance in the fight against...

Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible

...experiments within the same labs. “Thisstudy is a key first step in moving gene expression data fromsmall-scale bench science into large-scale clinical evaluation,?saidJames Jacobson, Ph.D., chief of NCI’s Diagnostic Biomarkers andTechnology Branch.Gene expression microarrays have been used in numerous ...

Ancient olfaction protein is shared by many bugs, offering new pest control target

...versity scientists who had previously identified a key gene essential for the sense of smell in fruit flies now shows that this gene's function appears to be evolutionarily conserved across very different insect species. Research by Leslie Vosshall's laboratory had previously shown that of 62 odorant-re...

HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs

...discovered that protease inhibitors do block these key channels. "Our findings suggest that as a class, protease inhibitors may predispose individuals to QT interval problems or torsade de pointes," Dr. Badley says. Dr. Ackerman adds, "Long QT-adverse events are serious side effects in drugs, but with e...

1 2 3 4 5 6 7 8 9 10