Study: 'homemade' gene expression technology unreliable
...cles about microarrays appearing this month in the journal Nature Methods. They show that geographically separated multi-investigator teams adopting common commercial, rather than homemade, microarray platforms and common sets of procedures are able to generate comparable data. "The important point of the t...A puzzle piece found in unraveling the wiring of the brain
...iring. A report on their work appears today in the journal Neuron. "We were surprised to find an exocyst mutant having such specific defects," said Bellen, professor of molecular and human genetics at BCM. "The cell biological basis of brain wiring is largely unknown. We are happy to have a new handle on an...Duke engineers develop new 3-D cardiac imaging probe
...shed this month in volume 26 issue number 4 of the journal Ultrasonic Imaging. (Note: Because the journal's publication is backlogged, the issue date is 2004.) The research is funded by the Heart, Lung and Blood Institute at the National Institutes of Health and by the National Science Foundation. One form...New tumor-suppressor gene discovered
...ill be published in the 11 March 2005 issue of the journal Cell. "This discovery extends our understanding of how tissue growth is controlled both during normal development and during the formation of tumors, and it raises the possibility that the function of this gene may have important implications for the...Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression
...of genetic expression. In the latest issue of the journal Cell, the Scripps Research team, led by Immunology...Han and appears in the March 11, 2005 issue of the journal Cell (120, 1-12). ...Protein helps regulate the genes of embryonic stem cells
...on. The findings appear in the May 24 issue of the journal Current Biology. The research offers an important contribution to a new wave of thinking in genetics: that not all human disease states are due to alterations in DNA sequence. Dr. Terry Magnuson - Sarah Graham Kenan professor, chairman of genetics a...The evolutionary triumph of flower power
...ies depends mainly on us. A recent article in the journal "Evolutionary Psychology" by McGuire; Jeannette Haviland-Jones, a professor of psychology at Rutgers, The State University of New Jersey; and others, states that in spite of some basic survival uses such as edible or medicinal flowers, most flowering...Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
...archers plan to submit the results to a scientific journal in coming weeks. Enigmols are synthetic analogs of sphingolipids, a group of cell-signaling molecules that help cells decide whether to grow or die via a controlled process called apoptosis. Cancer cells are usually defective in these regulatory pat...Roots Engage in Underground Chemical Warfare
...The work is published in the March 10 issue of the journal Nature. The exudates from Arabidopsis roots kill a wide range of bacteria, confirming that roots are not always vulnerable, anchored targets. The natural production of these antimicrobial chemicals offers one explanation for why so few bacteria type...Habitat use by North Pacific right whales, Eubalaena japonica, in the Bering Sea and Gulf of Alaska
...ries. These results were published recently in the journal Mammal Review. Based on re-analyses of whaling records and surveys, important areas appeared to be (1) the Southeastern Bering Sea slope and shelf, (2) eastern Aleutian Islands, and (3) Gulf of Alaska slope and abyssal plain. Since 1980, the only ar...New World founders small in number
...d. In a paper published in the premier open-access journal PLoS Biology, Jody Hey now reveals how the sizes of the first New World populations have changed since they were founded. His new approach shows that the New World was colonized by a surprisingly small population with an effective size of only about ...Biochemists report discovery of structure of major piece of telomerase; implications for cancer
...ery is the cover story in the March 4 issue of the journal Molecular Cell. "Knowledge of the structure should provide insights into how telomerase works," said Juli Feigon, professor of chemistry and biochemistry at UCLA, who led the research group. "Knowing the structure also will allow the pursuit of rati...Plant Sacrifices Cells to Fight Invaders
...ss was a mystery. Now, in the May 20 issue of the journal Cell, Yale University's Savithramma Dinesh-Kumar and his colleagues report finding a gene that normally propagates a "pro-survival" signal in plant tissue. Without that input, an alternate "pro-death" signal moves out of the infected areas and damage...Scientists discover that three overlapping signals in embryo help get the backbone right
...operly. The discovery, reported this month in the journal Developmental Cell by researchers at the University of California, Berkeley, finally explains an 80-year-old observation that revolutionized the way biologists think about embryonic and fetal development and set the stage for the stem cell debate. T...Advancements In Genomics Foster Deep Sea Discoveries
... in a scientific paper in the March 4 issue of the journal Science. In the paper and ACS presentation, Bartlett and colleagues at the University of Padova (Italy), presented the first genetic blueprint for bacterial life in a cold deep-sea environment. They also presented a detailed analysis of how the bac...Oceans more vulnerable to agricultural runoff than previously thought, study finds
... in the sea. Writing in the March 10 issue of the journal Nature, the authors conclude that some highly productive regions of the ocean are much more vulnerable to agricultural runoff than was previously assumed. The study is based on satellite imagery of Mexico's Gulf of California, also known as the Sea ...Elephant seal pups suffer from ocean warming
...eals, reveals a study published in the Open Access journal BMC Biology. High ocean temperatures observed from 1975 to the late 1990s are correlated with a 28% decrease in the weight of elephant seal pups. Elephant seals are shown to be sensitive to ocean temperature changes associated with both long-term 25-...Signs of aging: Scientists evaluate genes associated with longevity
... process. Their results appear online today in the journal Genome Research. Led by Dr. Angela Brooks-Wilson, Senior Scientist at the BC Cancer Agency's Genome Sciences Centre, and Dr. Donald Riddle, Professor of Biology at the University of Missouri, the team prepared SAGE (serial analysis of gene expressio...MUHC researchers make cancer target breakthrough
...new study, published in the on-line edition of the journal Clinical Cancer Research this week, the researchers document a reduction in the growth of both colon and lung cancer tumors with inhibition of the gene. The new target gene is called methylenetetrahydrofolate reductase, or MTHFR. Researchers were ab......other radionuclides. In research published in the journal Environmental Microbiology, Laboratory chemist Mary Neu and her colleagues describe their study of different naturally occurring bacteria used to treat actinide contamination. Actinides are the elements above atomic number 89 and are usually radioact...