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Tag: "itself" at biology news

3D Atlas Will Help Navigate The Spinal Cord

...nd, eventually, clinical observations. Though not itself directed at a cure for the consequences of spinal cord injury, the project will accelerate progress of such research because it will permit scientists to navigate seamlessly between the rat and human spinal cords to test hypotheses inspired by human ...

MicroRNA tweaks protein that controls early heart development

... a common mechanism through which a cell regulates itself at various stages, both during development and later in life," he said. "This is a rapid way to regulate protein levels. You can imagine a pool of messenger RNA ready to make a protein, and by virtue of a microRNA, that protein synthesis can immediat...

Duke Experiments Boost Radiation's Cancer-Killing Effects

...inhibited a tumor's ability to sustain and nourish itself by growing new blood vessels around the tumor. Mo...istant to radiation." Moreover, because radiation itself boosts HIF-1 levels, blocking HIF-1 at the height of its activity ?after radiation has occurred -- i...

IBM Transforms the Art of Scientific Expeditions

...inhibited a tumor's ability to sustain and nourish itself by growing new blood vessels around the tumor. Mo...istant to radiation." Moreover, because radiation itself boosts HIF-1 levels, blocking HIF-1 at the height of its activity ?after radiation has occurred -- i...

Researchers predict infinite genomes

...genomes reflect reality? As comparative genomics itself evolves, Fraser expects TIGR to increasingly focus on pan-genomes. Many questions remain. Although some microbial species, such as GBS, have infinite pan-genomes, for instance, others are more limited. Comparing eight independent isolates of Bacillu...

Hopkins scientists uncover 'tags' that force proteins to cell surface

...or a very close relative. The eight-block-long tag itself is part of the so-called C-terminal end of these proteins, and its existence helps explain why some engineered proteins don't go where they're supposed to go, Li says. "If you remove a small part of the very end of a protein, it seems unlikely to d...

Sleeping beauty plays a significant role in identifying cancer genes

...ada. "By comparison, the jumping gene has inserted itself into cancer genes in the tumors we studied and thereby allows us to focus on smaller numbers of genes -- genes that we know are important to the genesis of tumors. The result is a quicker, more efficient and accurate identification of cancer-causing ...

Why do aneurysms form? New studies suggest leading role for white blood cells

...at showed that the lack of MMP-8 was not enough by itself to keep aneurysms from forming. "Something else must be at work," says Upchurch, "and we're trying to find out what that is." In the second study, the researchers looked at L-selectin, a protein on the surface of neutrophils that allow them to atta...

Old drug, new tricks: Prospects for slashing the impact of malaria

...st-infection treatment for malaria. While the drug itself dissipates in the bloodstream over a few days, it appears to enable the immune system to re-energize and more successfully combat any subsequent malarial infection. We suspect that many toddlers who seem reasonably healthy might actually have low lev...

UIC developing drug for SARS

...ing the machinery of the cells it infects to clone itself over and over again. One of the first steps in that process is the production of a long chain of proteins, all of which are needed for the virus to propagate. Two enzymes, or proteases, clip the chain to release the individual proteins, the parts ne...

Sugar helps control cell division

...e for a reason." But understanding what the sugar itself is doing and how its presence on or absence from proteins affects the cell depends solely on what protein it's being attached to or removed from. "Whether it's turning something on or off depends on the protein to which the sugar is attached," says ...

Weight control protein may yield antiobesity drugs

...nce to leptin's usual effects. As a result, leptin itself has proven to be insufficient for obesity therapy. The new findings reveal SH2-B as a critical component in maintaining leptin sensitivity, Rui said. Therefore, SH2-B and signaling events regulated by SH2-B may serve as potential therapeutic targets...

Researchers discover how malaria parasite disperses from red blood cells

... the cell membrane appears to collapse inward upon itself and fragment into pieces. One previous theory held that the red blood cells and the merozoite-containing vacuoles inside them swelled and then burst like a balloon containing too much air. "The swelling was an artifact of too much light from the mi...

New technique could alter field of mouse genetics

...zyme, piggyBac can reliably and efficiently insert itself into the genomes of human and mouse cell lines and...ects. In their experiments, piggyBac incorporated itself into many chromosomes in human and mouse cells. It also carried other genes effectively. Inserted in...

Variant prion protein causes infection but no symptoms

... not produce symptoms. "Abnormal prion protein by itself may not be rapidly lethal--in these mice it wasn't," Dr. Chesebro says. ...

New law for resolution allows unprecedented sharpness in fluorescence microscopy

...mit can be produced without confining the solution itself mechanically. This method may substantially improve the analysis of pharmaceutical active ingredients and protein interactions in cells in future. Original work: [1]Hell, S. W. Strategy for far-field optical imaging and writing without diffraction ...

Trio of plant genes prevent 'too many mouths'

...ual purpose of keeping the plant from wallpapering itself with too many densely clustered stomata. "It's surprising that size and stomata patterning ?both key to plants being able to survive on dry land ?are using the same signaling components," says Jessica McAbee, a University of Washington research asso...

Virus uses tiny RNA to evade the immune system

...searchers have found that a virus appears to cloak itself with a recently discovered gene silencing device to evade detection and destruction by immune cells. The report by Howard Hughes Medical Institute (HHMI) researchers in an article published in the June 2, 2005, issue of Nature may be the first to sh...

Learning how SARS spikes its quarry

...ble the animal SARS virus to infect humans, but by itself this mutation does not appear to allow subsequent human-to-human transmission. "The observation is that a dramatic epidemiological difference can result from what looks like an almost trivial mutation," said Harrison. "These findings give us the be...

Researchers discover new tumor defense system

...cytes. Thus the cancer may have a way of defending itself against attack by the immune system, thereby reducing the potential efficacy of novel anti cancer therapies that rely on a functioning immune system." The free fatty acids act against cytotoxic T lymphocytes by blocking a number of the lymphocytes' ...

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