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Tag: "itself" at biology news

Man and mouse share genome structures

...enome may be as important as changes in the genome itself in causing diseases such as cancer. This regulatory structure, called chromatin, is a key regulator of gene expression in healthy and diseased cells, Bernstein said. Chromatin is composed of DNA spooled around bundles of histone proteins, and resemb...

W.M. Keck Foundation funds study of friendly microbes

...ateful to the Keck foundation, which has committed itself to funding high-risk projects designed to overcome key obstacles in emerging fields in science so that rapid progress can subsequently be made," Gordon says. "Their support of our studies of the genomic and metabolic foundations of mutually beneficia...

New binding target for oncogenic viral protein

... is deleted in up to 30% of human tumors. "Fbw7 is itself an important tumor suppressor which makes it an attractive choice for inactivation by Large T," explained Dr. Markus Welcker, the study's first author. The research appears as the "Paper of the Week" in the March 4 issue of the Journal of Biological...

Controversial drug shown to act on brain protein to cut alcohol use

...In a separate study, theydemonstrated that GDNF by itself decreases alcohol consumption.The research is being published in the January 19 issue of The Journalof Neuroscience."By identifying the brain protein that Ibogaine regulates to reducealcohol consumption in rats, we have established a link between GDN...

Elusive HIV shape change revealed; Key clue to how virus infects cells

...d-after information on how the molecule rearranges itself when it encounters the CD4 receptor. "Knowing how gp120 changes shape is a new route to inhibiting HIV ?by using compounds that inhibit the shape change," says Harrison. He notes that some HIV inhibitors already in development seem to inhibit the sh...

Plants respond similarly to signals from friends, enemies

...m a distance and therefore does not need to attach itself to the plant to elicit a response. When the researchers studied L. japonicus plants missing the receptors that receive signals from other organisms ?certain genes in the plant were modified to accomplish this ?they discovered that the plants failed ...

U-M scientist to talk about tissue engineering at AAAS

..."In certain kinds of defects, the body cannot heal itself and the body needs a jumpstart," Krebsbach said. To heal a large wound, like that created when a cancerous tumor is removed from the jaw, that often means taking a bone graft from someplace like the hip. That approach has problems both for the wound ...

Solution to Pollution: New Bacteria Eats Toxic Waste

...technology, said Sims. “This research is extending itself to the world, and we are really excited about it,?said Anne Anderson, a biology professor and team member. The group wants to fully understand how these microbes function and survive in the environment so contaminated sites around the world can reap...

Needling Chromosomes Reveals Cell Division Secret

.... DNA, whichmakes up genes in the cell, replicates itself as a central process inchromosome duplication."So, we’re left with the mystery of what molecules hold the chromatidstogether at this point in cell division,?Nicklas said. "But that’s theusual outcome of work in my laboratory and a sign that we're doi...

Highly adaptable genome in gut bacterium key to intestinal health

...s its host with nutrients while obtaining food for itself and other gut bacterial species. The complete genome sequence of B. theta was generated two years ago in the same laboratory. The researchers inoculated germ-free mice, who have no intestinal bacteria, with B. theta. The mice were fed a diet high in...

Researchers find missing genes of ancient organism

...r they may represent a specialization that has rid itself of genetic baggage to exist in extreme environments." Understanding how primitive organisms like Nanoarchaea operate gives clues to -- but not proof of -- the relationship between modern and ancient organisms. ### Other authors on the paper includ...

Scientists identify genetic pathways essential to RNA interference

...s in plants or animals. They used the RNAi process itself to find new genes that participate in the gene-silencing mechanism, which someday may help to fight human disease. The report will appear in the journal Science and is receiving early online release on the Science Express website at http://www.scienc...

DNA Recombination and Repair—A New Twist to RecA Function

... ATP-dependent assembly of actin or tubulin fibers itself can work as a motor: for instance, the march of white blood cells toward pathogens is powered by the growth of actin filaments pushing against the cells?membranes. In all cases, coherent motion implies a coordinated and polarized use of energy. Now,...

New protein discovered by Hebrew University researchers

...'s cells. The SP-1 also has the ability toassemble itself into a structure composed of 12 identical units, makingit exceptionally resistant to extreme conditions. These qualities arerarely found among proteins and make the SP-1 a promising candidate fora multiplicity of uses in developing medicinal applicat...

The death of a very special chimpanzee

...'s cells. The SP-1 also has the ability toassemble itself into a structure composed of 12 identical units, makingit exceptionally resistant to extreme conditions. These qualities arerarely found among proteins and make the SP-1 a promising candidate fora multiplicity of uses in developing medicinal applicat...

UCLA scientists transform HIV into cancer-seeking missile

...ic genes that can travel through the blood and aim itself at a precise location, thereby minimizing harmful side effects," explained Irvin S.Y. Chen, Ph.D., director of the UCLA AIDS Institute. "Our approach proves that it is possible to develop an effective carrier and reprogram it to target specific cells...

Breast Cancer May Be 'Uniquely Sensitive' To Inhibitors Of PI3K Pathway

...evels inbreast cancer, including mutations in PI3K itself or its many“downstream?players, such as PTEN, or AKT.“There is a lot of crosstalk between the PI3K pathway and otherpathways, a lot of feed-forward and feedback loops,?says Mills. “But Iand others believe there are central nodes between these interse...

Genetic Variation Visualization - From EMBL

...evels inbreast cancer, including mutations in PI3K itself or its many“downstream?players, such as PTEN, or AKT.“There is a lot of crosstalk between the PI3K pathway and otherpathways, a lot of feed-forward and feedback loops,?says Mills. “But Iand others believe there are central nodes between these interse...

New Mixing Method for Microchip-Sized Labs

...evels inbreast cancer, including mutations in PI3K itself or its many“downstream?players, such as PTEN, or AKT.“There is a lot of crosstalk between the PI3K pathway and otherpathways, a lot of feed-forward and feedback loops,?says Mills. “But Iand others believe there are central nodes between these interse...

Tiny scaffolding allows stem cells to become working fat cells

...he environment in which a community of cells finds itself has a great deal of influence on the biology underway within those cells," Kniss said. "And that biology is always translated into changes in gene expression and assemblies of proteins." That is why the three-dimensional scaffolding for cell growth i...

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