Elusive HIV shape change revealed; Key clue to how virus infects cells
...120 after it binds to the CD4 receptor and changes its shape was solved several years ago by another grou...olution three-dimensional images of the protein in its unbound form. They surmounted considerable technical challenges, including difficulty in getting gp1...Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
...ls the degradation of the E. histolytica genome in its transition from a free-living organism into a para...stolytica likely picked up a significant number of its metabolic genes from bacterial co-inhabitants of the human gut. Identification of these genes sheds ...Anti-bacterial additive widespread in U.S. waterways
...nvironmental Health Sciences andfounding member of its Center for Water and Health.The nationwide assessm... andhuman health risks of triclocarban."Along with its chemical cousin triclosan, the antimicrobial compoundtriclocarban should be added to the list of pol...Newly-discovered class of genes determines ?and restricts ?stem cell fate
...oth tell a cell what it should become and restrict its fate by preventing differentiation. The ability of a single biochemical factor or complex of factors to have this dual role may represent a new general paradigm for developmental and stem-cell biology. "My idea is that this is a new family of genes--...Timing is everything: First step in protein building revealed
...ing line for a gene'sinstructions, it first alters its structure and then releases a factorknown as eIF1,... FRET, to monitor therelationship between eIF1 and its relative as the ribosome complexassembled and after RNA was added to the mix."We weren't even sure t...Tiny particles could solve billion-dollar problem
...most hazardous chemicals at these sites because of its prevalence and its toxicity. Human exposure to TCE has been linked to liver damage, impaired pregnancies and cancer. C...Researchers Uncover Key Step In Manufacture of Memory Protein
...oes not take place, proBDNF cannot be converted to its active form. Dr. Loh explained that the proBDNF molecule has four projections, resembling prongs. These prongs fit into a corresponding indentation on CPE, analogous to the way a plug for an electric appliance fits into an electric wall outlet, Dr. L...Plants respond similarly to signals from friends, enemies
...s, even though the nematode provides no benefit to its host. Root-knot nematodes form feeding cells ?so-called giant cells ?in the plant and later galls or knots on it. "We don't know the precise structure of Nematode factor, but it appears that the nematodes may have actually acquired genes from rhizob...Research advances quest for HIV-1 vaccine
...lex formed by an anti-HIV antibody called 4E10 and its specific target provides insight into why this particular antibody is so broadly effective, a rare characteristic for HIV discovered thus far. The research is published in the February issue of Immunity. Vaccination has been a successful strategy fo...The secret to longevity in tubeworms
...nd colleagues now provide a solution: by releasing its waste sulfate not up into the ocean but down into ... growth of sulfide-producing microbes, and ensures its own long-term survival. The sulfide this worm needs is created by a consortium of bacteria and arch...Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering
...d animal genomearrays available in 2005 as part of its Consortia Program, includingcanine, Rhesus macaque, Medicago trancatula (legume), Brassica, tomato,citrus, poplar and sugar cane. More than 20 research presentations atthis week's Plant and Animal Genome Conference XIII in San Diego,Calif. feature Af...Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates
...s over 15 years ago, however the field is still in its infancy.Researchers from Kyoto University have now shown thatdopamine-producing neurons (DA neurons) generated from monkey embryonicstem cells and transplanted into areas of the brain where these neuronshave degenerated in a monkey model of Parkinson...A much-needed shot in the arm for HIV vaccine development
... research. In June 2004, the G8 countries endorsed its goals,and will consider the new plan at its forthcoming summit meeting in theUnited Kingdom this July. Thecoordinating committee of the plan re...Study Links Ebola Outbreaks To Animal Carcasses
...udy by the Wildlife Conservation Society (WCS) and its regional partners. Appearing in the February edition of the journal Emerging Infectious Diseases, the study found that many animal carcasses tested for Ebola between 2001 and 2003 produced positive results, and found direct links between the deadly d...Bound for destruction: Ubiquitination protects against improper Notch signaling
...f ubiquitin proteins. This system is best knownfor its function in marking proteins for degradation by a wastedisposal unit known as a proteasome. Hayashi et al. sought to study thepossibility that ubiquitination might play a part in rendering theunbound Notch receptor inert. Their attention was drawn to...Whole genome fine map of rice completed
...map for the paternal strain¡°93-11¡± (Indica), and its comparison with the genome sequence of the Japonica. It is reported that BGI will finish whole genome assembly and analysis for the maternal strain "PeiAi 64" (its main genetic background being Japonica, as well as a mixture of Indica and Japonica g...Research on Worms Yields Clues on Aging
...uvence" forever; a way to slow orstop aging. While its still nowhere to be found, we are makingprogress; in worms. Researchers found that an epilepsy drug used inhumans had the unexpected effect of prolonging the life span of C.Elegans: A class of anti-seizure medications slows the rate of aging inroundw...“Nano-scissors?laser shows precise surgical capability
...roscaled worms ( C. Elegans )is quite a challenge; its about 1 mm in length. A research team fromthe Univ...atile tool.?The beauty of this laser, she says, is its ability to cut organelles(parts of cells—they are what organs are to organisms) precisely,without da...U-M scientist to talk about tissue engineering at AAAS
...ike a jaw bone damaged too badly to simply heal on its own. A tiny scaffold helps direct the engineered cells to the right place, then dissolves once the cells begin to generate to fill in the wound. "In certain kinds of defects, the body cannot heal itself and the body needs a jumpstart," Krebsbach sai......on the other hand, it loses at least 30 percent of its intensity, it is regarded as methylated. In the study, the research team tested 2447 fragments in each animal. They found anywhere from 45 to 209 (.8 percent to 8.5 percent) of the fragments methylated in the mice with cancer, but only one or two me...