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Tag: "isolated" at biology news

Man and mouse share genome structures

...an genome, they collaborated with Affymetrix. They isolated the DNA regions with certain major methyl and acetyl tags, and used new microarray technology to identify the underlying genetic sequences associated with the tagged chromatin. Next, they teamed up with Michael Kamal, the co-first author of the paper...

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...or the function of PGC-1beta co-activator that was isolated in 2002. Experiments including the measurement of gene activity by microarrays showed that saturated and trans fats caused greater activity of the gene that makes PGC-1beta co-activator than did unsaturated fats. The research also showed that when t...

Lack of enzyme turns fat cells into fat burners

... of fatty acid andglucose in cultures of fat cells isolated from both normal and mutantmice that lacked ACC2. When the mice were fed a normal diet, fatty acidoxidation was 80 percent higher in the fat cells of the mice lackingACC2 when compared to normal mice. When they were fed a high fat, highcarbohydrate d...

Termites feed through good vibrations

...me fertile and develop into breeders when they are isolated from their colony. Few workers developed into breeders in the experiments when they were broadcast the termite sourced signals, whereas many workers developed into breeders when artificial signals were broadcast, or when no signals were broadcast. S...

Scientists detect probable genetic cause of some Parkinson's disease cases

...mor, a major symptom of Parkinson'sdisease. It was isolated on a region of chromosome 12 called PARK8 byinvestigators who studied five families with a history of Parkinson'sdisease who lived in the Basque region of Spain and in England.In these new studies, the researchers sought to determine theprevalence of...

Bacteria collection sheds light on urinary tract infections

... of California-Berkeley, found that E.coli strains isolated from patients with UTIs were genetically related t...orth America. The center has 60,000 E.coli strains isolated from cows, birds, pigs, humans, dogs, water and the environment. The center is located in the Depart...

Researchers reveal the infectious impact of salmon farms on wild salmon

...t impact over a very large area." The researchers isolated the effect of the salmon farm by studying the infection levels of migrating juvenile pink and chum salmon as they approached and passed a salmon farm. Within the study area, the salmon farms are anchored in a long thin fjord. Here the wild salmon hav...

First 'atlas' of key brain genes could speed research on cancer, neurological diseases

...ntranscription factors had not been systematically isolated and theirlocations within different parts of the brain pinned down.The map should tell scientists studying different parts of the brain,which transcription factor (TF) genes regulate the development of thatbrain region, and which of them to investiga...

NIAID Initiates Trial of Experimental Avian Flu Vaccine

... is an inactivated vaccine made from an H5N1 virus isolated in Southeast Asia in 2004. Sanofi pasteur, formerly Aventis Pasteur, was awarded a contract by NIAID to manufacture the H5N1 vaccine in May 2004. This Phase I trial will test the vaccine’s safety and ability to generate an immune response in 450 hea...

NC State scientist finds soft tissue in T. rex bones

... which she and her technician, Jennifer Wittmeyer, isolated soft organic tissue from the leg bone of a 68-mill...earch will reveal exactly what the soft structures isolated from these bones are made of. Do they consist of the original cells, and if so, do the cells still c...

Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells

... the mitochondria in the cancer cell sit all over, isolated and balled up in a quiescent, non-functioning stat...n fluids taken directly from the body, rather than isolated by type in a flask. This problem will be solved by winnowing out unlikely particles through size and...

Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimer's, Parkinson's Disease

...to the AFM microscope tip. They can then bring the isolated and suspended molecules together to study how and whether they interact. The Duke researchers study these interactions by retracting the tip of their AFM, which can measure changes in force at the atomic scale. Pulling back the tip can induce a meas...

VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain

...heir predisposition to drink alcohol. Researchers isolated tissue from three different regions of the brain that are all known to play a role in responses to alcohol and other drugs of abuse. Using DNA microarrays, which measure the activity of more than 10,000 genes simultaneously, together with large datab...

How an AIDS-Related Cancer Unleashes Inflammation

...he researchers conducted experiments in which they isolated proteins that bound with kaposin B in the cell. That screening revealed that kaposin B binds to a protein called MK2, which is known to play a role in boosting cytokine production. In further experiments, they discovered that the binding of kaposin ...

New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines

...n. Some broadly neutralizing antibodies have been isolated from HIV-infected humans, although the antibodies are rare, with less than five identified. "We know these antibodies can exist, but we have not been able to give a vaccine to people or animals that stimulates the production of these types of antibod...

Asthma gene clusters identified

... based on an Affymetrix "GeneChip" analysis of RNA isolated from the nasal epithelium of children who have an acute case of asthma or asthma stabilized with medication. The analysis revealed two distinct gene expression profiles in these groups of children, according to Gurjit K. Khurana Hershey, MD, PhD, dir...

Variation in women's X chromosomes may explain differences among individuals, between sexes

...on, Willard said. In their study, the researchers isolated cell lines from each of 40 women. They then measured the activity level of each of 471 genes to determine whether the second copy was turned on or off. Overall, about 15 percent of genes on the second X chromosome escape inactivation to some degree,...

World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics

...r-old woman's pancreas. Dr. Shinichi Masumoto then isolated the living islets in the Kyoto Centre for Cell and Molecular Therapy. Under Dr. Shapiro's supervision, the team then transplanted the insulin-producing cells into the woman's 27-year-old diabetic daughter. The transplanted islets began producing ins...

Gene Signatures Predict Interferon Response For Multiple Sclerosis Patients

...ed by partial or full recovery), and their RNA was isolated from a class of immune cells called peripheral blood mononuclear cells. After patients started interferon therapy, blood was taken at specific time points over the course of two years. Baranzini et al. measured the expression level of 70 genes—includ...

Advances in the characterisation of the oyster mushroom genes

...: the cellobiohydrolases. To this end, she cloned, isolated and sequenced those genes of the oyster mushroom responsible for this activity and investigated the culture in which each of these genes expresses itself. Five genes of one family The PhD work resulted in the isolation of five genes of the oyster m...

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