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Tag: "isoform" at biology news

How mammals fuel milk production may have implications for cancer

...sential for lactation and establish a role for the isoform in glucose metabolism, a function earlier linked almost exclusively to Akt2, they said. The findings may have important implications for cancer therapy, as the Akt pathway is also one of the most commonly activated in cancer, Chodosh said. “Th...

Cycles of cell death, proliferation key to liver cancer

...tly, deletion of the gene that codes for the major isoform of JNK in liver cells, JNK1, prevented the development of liver cancer and reversed the tumor-enhancing effect caused by ablation of IKKƒÒ. "We found that long-term JNK activation leads to cell death; if activated briefly, it stimulates proliferatio...

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