Biologists probe the machinery of cellular protein factories
...ed a technique called x-ray crystallography, which involves growing crystals of purified ribosomes, shining a focused beam of x-rays through the crystals, and analyzing the resulting diffraction pattern. Trakhanov prepared the crystals and Korostelev and Laurberg performed the crystallography and solved the s...Protein 'fingerprint' in spinal fluid could spot Alzheimer's disease
... funded, multicenter trial going on right now that involves many more patients, in which many enrollees will undergo spinal taps and brain imaging," Relkin said. "We hope to link into that effort to expand on these findings." The dream of a highly accurate Alzheimer's disease test that patients and doctors ...Vaccine for brain tumors shows promising results
...ients with recurrent, high-grade glioma. The trial involves two groups of six patients, both of which receive a minimum of four injections: the first group receives biweekly vaccinations and the second receives weekly vaccinations. Patients are monitored for immune response before, during and after treatment....Slow brain waves play key role in coordinating complex activity
.... "A simple activity like responding to a question involves areas all over the brain that hear the sound, anal... understanding diseases like autism, which clearly involves the subcortical pathways." In these clinical procedures, Barbaro removed a portion of each patient'...Researchers create genetically matched embryonic stem cells for transplantation
...technically demanding and inefficient process that involves transferring the nucleus of a donor cell into an egg from which the nucleus has been removed. "We will not stop testing nuclear transfer, because it is the only means we know for generating embryonic stem cells that are genetically identical to a ...Fighting like a girl or boy determined by gene in fruit flies
...study shows. Female fighting, for example, largely involves head butts and some shoving. Males prefer lunges; they rear up on their back legs and snap their forelegs down hard ?sometimes nailing an opponent that is slow to retreat. The flies undergo a major role reversal when the male and female gene versi...World's smallest cancer detection device
... Albany researchers will use nanotechnology, which involves studying and working with material on the molecular level, to design a "microchip" version of the artificial blood vessel that Dr. Condeelis has used successfully in animals. The microchip will be assembled from nanoscale components so that several d...PNAS study reveals why organs fail following massive trauma
...hich are getting worse, in almost any disease that involves the immune system." ...Dragonfly's metabolic disease provides clues about human obesity
...toms of metabolic syndrome in humans. One symptom involves the signaling molecule, p38 MAP kinase, a common indicator of stress response in humans and other animals. The signaling molecule was chronically activated in the flight muscles of parasite-infected dragonflies, but not in muscles from healthy drago...Mars mission Risk 29: Scientists research ways to reduce radiation-induced brain damage
...made matters more complex, one possible trajectory involves flying around Venus and using its gravitational pull to sling the spacecraft toward Mars. That means flying closer to the sun and spending months on the opposite side. "The sun is basically a big nuclear reactor," said Britten. The scientists hop...History-hunting geneticists can still follow familiar trail
...ne edition of Science validate the approach, which involves tracking sequences of mitochondrial DNA, also known as mtDNA. "The study of mtDNA has helped to demonstrate the African origin of our species and the relationship between living humans and the Neanderthals," said Connie Mulligan, an associate prof...New technology used to construct the first map of structural variation in the human genome
... as comparative genomic hybridization (CGH), which involves tagging genomic DNA from two individuals and then co-hybridizing it to the array. Data from the array were assessed with a new algorithmic tool, called CNVfinder, which accurately and reliably identified CNVs in the human genome. "This method hel...Renewed dolphin slaughter prompts new campaign
...esearch Program. The "Act for Dolphins" campaign involves scientists and veterinarians from the New York Aquarium, Emory University, the School of Medicine at the University of San Diego, Dalhousie University, the University of Hawaii, the University of Notre Dame, and professionals from the World Associati...For super-obese patients, duodenal switch beats gastric bypass
...c operations in 2002--is the gastric bypass, which involves stapling off a large portion of the stomach to make overeating difficult, and rerouting the intestines to reduce the absorption of calories. The duodenal switch--fewer than eight percent of all bariatric procedures performed nationwide--leaves a slig...Honey bee genome holds clues to social behavior
...ansition, whether triggered by age or social cues, involves changes in thousands of genes in the honey bee brain; some genes turn on, while others turn off. Genes are switched on and off by short strings of DNA that lie close to the gene. The strings serve as binding sites for particular molecules, called t...Gene therapy study takes aim at prostate cancer
...ix different doses of the gene. The gene therapy involves attaching an inactivated adenovirus (related to viruses that cause respiratory infections) to the RTVP-1 gene. As the virus infects the tumor cells, it will introduce the gene into the cells as well. (RTVP stands for related to testes-specific, vespi...Second opinion yields treatment changes for half of patients
...l Cancer. “A multidisciplinary tumor board that involves the collaborative effort of multiple medical specialties allows expert opinion and recommendations based on the most recent research findings. Meanwhile, the patients come to only one setting, with no need to visit multiple specialists individually,?...Fat stem cells being studied as option for breast reconstruction
...ues are focusing their efforts on an approach that involves combining the fat-derived stem cells with microscopic beads composed of a type of extracellular matrix (ECM) that has regenerative properties. Preliminary results indicate that the stem cells can easily attach themselves to these beads and are able t...MIT nanoparticles may help detect, treat tumors
...esearch, which is just moving into animal testing, involves injecting nanoparticles (billionths of a meter in size) made of iron oxide into the body, where they flow through the bloodstream and enter tumors. Solid tumors must form new blood vessels to grow. But because this growth is so rapid in cancerous tu...Genetic 'roadmap' charts links between drugs and human disease
...rising results to emerge from the Connectivity Map involves gedunin, a plant derivative that, despite a long history of medicinal use, is not well understood molecularly. The researchers identified gedunin in a high-throughput chemical screen for molecules that disrupt hormone signals in prostate cancer cells...