Researchers discover new form of cancer gene regulation
...ritical to early development of humans and animals involves the genes Sonic hedgehog (the signal) and GLI (the transcription factor). The GLI family of three genes was first discovered in a human brain tumor, and mutations in this family of genes result in severe birth defects and devastating cancers in hu...OHSU discovery sheds light into how stem cells become brain cells
...next step." said Sherman. "Since the process only involves a single gene, it is highly amenable for the development of drugs targeted at promoting stem cell differentiation in the adult nervous system." While much more research needs to be conducted, the scientists believe these findings could play a role ...How E. coli bacterium generates simplicity from complexity
... living things, generates energy in a process that involves the removal of electrons from food molecules and attaching them to acceptor molecules. For aerobic organisms, the final electron acceptor is usually oxygen, which is converted into water in the process. E. coli can grow with or without oxygen, using...MIT researcher presents new view of how the cortex forms
...e indicates that the development of cortical areas involves "a rich array of signals," an interwoven cascade of developmental events, some internal and some external, according to co-authors Mriganka Sur, Sherman Fairchild Professor of Neuroscience at the Picower Institute for Learning and Memory and the MIT ...Olfactory system detects pheromones that control reproduction
...system, which is found in a wide range of mammals, involves detection of chemical odorants released by animals. Pheromones are chemicals that are involved in changing behavior or hormone secretion. According to most biology textbooks, detection of pheromones takes place in a specialized structure, called the ...Cancer support cells may evolve, fuel tumor growth, study shows
...ears, it has become increasingly clear that cancer involves complex interactions among different types of cell compartments, and, as in any organ, these compartments comprise blood vessels, supporting tissue and immune cells," said Van Dyke. "The interaction between the predominant cancer cell type and other...Effective, safe anthrax vaccine can be grown in tobacco plants
...obacco plants." Current production of the vaccine involves an expensive fermentation process that can cause harmful side effects such as inflammation, flu-like symptoms and rashes. This has prompted some people to refuse to be vaccinated. Seeking a safer and more effective alternative, Daniell and his colle...Implantable pumps extend lives of patients too sick for transplant
...ce of infection." Another technological challenge involves the pump itself, Rogers said. The Novacor device is a pulsatile pump which contains blood in a polyurethane sack. The blood is then propelled out of the pump between two pusher plates. However, because of its size, it cannot be used in children or co...Researchers show key protein necessary for normal development of red blood cells
... According to Lloyd, the production of blood cells involves a complex differentiation pathway that involves the interaction of many molecular players and proteins. In humans, there are four globin genes clu...Carnegie Mellon scientists create PNA molecule with potential to build nanodevices
...is pattern. A similar pattern—which, surprisingly, involves different genes—is found in the brain of the aging chimpanzee. The authors compared results from three separate studies of age-related gene expression, each done on the same type of DNA microarray and each comparing brain regions in young versus old...Navigating the brain for sense of direction as paradigm for higher cognitive functions
...is pattern. A similar pattern—which, surprisingly, involves different genes—is found in the brain of the aging chimpanzee. The authors compared results from three separate studies of age-related gene expression, each done on the same type of DNA microarray and each comparing brain regions in young versus old...Gene Expression in the Aging Brain
...is pattern. A similar pattern—which, surprisingly, involves different genes—is found in the brain of the aging chimpanzee. The authors compared results from three separate studies of age-related gene expression, each done on the same type of DNA microarray and each comparing brain regions in young versus old...Scientists pinpoint inflammation gene
...uman disorders. "Practically every common disease involves an inflammation component," said John Blangero, Ph.D., a scientist at the Southwest Foundation for Biomedical Research (SFBR) in San Antonio and the paper's senior author. "So the discovery of a new player in the inflammation pathway opens up many po...New view of cancer: 'Epigenetic' changes come before mutations
... cells ready to cause new growth. The second step involves an initiating mutation within the population of epigenetically disrupted progenitor cells at the earliest stages of new cell growth, such as the rearrangement of chromosomes in the development of leukemia. This mutation normally has been considered t...Max Planck researchers make a breakthrough in plant stem cell research
... found to be important for this process. The first involves growth-promoting hormones like auxin and cytokinin...n already for more than half a century. The second involves genetic factors, which were discovered at the University of Tübingen, Germany about a decade ago. H...New possibilities for flu antiviral and vaccine research emerge from 'Spanish flu' virus
... used an approach called "reverse genetics," which involves transferring gene sequences of viral RNA into bacteria and then inserting combinations of the genes -- often after manipulating them -- into cell lines, where they combine to form a virus. For the Science study, Jeffery Taubenberger of the Armed Fo...Researchers know what you were about to say; fMRI used to detect memory storage and retrieval
...An every-day strategy for getting at lost memories involves using a part of a memory to pull out the entire thought, much like when you try remember where you put your keys last night," Polyn said. "If you recall that you were washing dishes, that might trigger associated memories, leading you to remember th...Marine conservation organizations team up to conduct Indonesia coral reefs assessment
...veys carried out at regular intervals. A manta tow involves towing a diver behind a boat while they record observations regarding ecological condition on an underwater slate. The Reef Check survey is the only standard method used to survey the world's reefs. Initial surveys in the region conducted by Reef Che...Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
...l and systematic approach to cancer treatment that involves the use of advanced technologies that are by themselves harmless − but appear to offer potent cancer-killing properties when used together. This tactic focuses on two main ingredients: structures called "nanoshells," which are microscopic ba......life throughout the region. Reversing the problem involves reducing the creation of new roads and subsequent use of deicers. Despite being a major aquatic pollutant, road salt is not currently regulated as a fresh water contaminant. ...