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Tag: "involved" at biology news

Study identifies predictors of HIV drug resistance in patients beginning triple therapy

...rease in acomponent of PKA, and PKA is known to be involved in neuraldevelopment. The BCE mixture is capable of altering neural development,and alterations in neural development are thought to be a cause ofautism," says Jill Kreiling, first author of the paper and a member ofReinisch's lab. But Kreiling cauti...

Mouse brain tumors mimic those in human genetic disorder

...tumors has helped usunderstand the cellular events involved in NF1 brain tumordevelopment," says principal investigator David H. Gutmann, M.D.,Ph.D., the Donald O. Schnuck Family Professor of Neurology.The study appears online and will be published in the January 2005issue of the journal Annals of Neurology.N...

Enzyme allows B cells to resist death, leading to leukemia

...o resist apoptosis. Theauthors suggest that Lyn is involved in the development of B-CLL andthat this enzyme therefore represents an attractive target for therapy.The study will appear online on January 13 in advance of publication inthe February 1 print edition of the Journal of Clinical Investigation....

Gene variations explain drug dose required to control seizures

...he first clear evidence linking variation in genes involved in the action or metabolism of the anti-epileptic ...gene known as CYP2C9, which encodes a liver enzyme involved in drug metabolism, showed a significant association with the maximum dose of phenytoin taken by pat...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

... second gene therapy strategy, in which the enzyme involved in Pompe disease is inserted into the liver, is also under investigation at Duke, said Koeberl. In the January 2005 issue of Molecular Therapy, the researchers reported that the liver-targeted method also corrected symptoms of Pompe disease in mice. ...

Scientists decipher genome of fungus that can cause life-threatening infections

... study identified greater than 30 new genes likely involved incapsule biosynthesis, including a family containing 7 members of thecapsule associated (CAP64) gene.Researchers compared two closely related genomes of C. neoformans thatdiffer markedly in their virulence properties. The results indicatethat the di...

Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease

...assive numbers of tags. HOX genes also are deeply involved in cancer, making the findings particularly import...ogical breakthrough, however. "Most prior studies involved only single genes, but we wanted to investigate entire chromosomes, which contain hundreds of genes,...

First 'atlas' of key brain genes could speed research on cancer, neurological diseases

...ave homed in on specific TF genesregulating nerves involved in pain sensation, certain brain tumors, andspeech...nd Ma has identified TF’s that regulate the nerves involved in thesensation of specific types of pain. Ma’s laboratory is focused on thestubborn problem of canc...

Critical role in programmed cell death identified

...th one component for each of the different factors involved in the central cell killing apparatus. Mammals on the other hand have multiple components or families of proteins for these factors; moreover, their cell death is more sporadic and harder to pinpoint. In worms, scientists know exactly which cells ar...

Highly adaptable genome in gut bacterium key to intestinal health

... The predominant group of high-activity genes were involved in the acquisition and digestion of carbohydrates. "In mice fed complex carbohydrates, we found that the microbes attached to small food particles in the intestine," Gordon says. "These carbohydrate-rich particles are the bacteria's dining room tabl...

Scientists identify genetic pathways essential to RNA interference

...f which have human counterparts ?code for proteins involved with the packaging and processing of RNA, but others may be involved with the regulation of DNA itself, including the repair of DNA damage. "These new steps indicate the...

Ants Genetic Engineering Leads To Species Interdependency

...and colleagues demonstrate thatboth of the species involved have effectively given up the ability toproduce pure-species workers in favor of the hybrids, thereby becomingcompletely dependent on one another for survival.Female ants are generally found in two forms: reproductive queens andsterile workers. The r...

Introduced foxes transformed vegetation on Aleutian Islands from lush grasslands to tundra

...uced to more than 400 islands. Byrd, who has been involved in restoration efforts in the Aleutian islands since 1971, said most of the islands had major breeding colonies of seabirds before the arrival of foxes. There are about 26 species of seabirds that regularly nest on the islands, he said. They include ...

Studies reveal methods viruses use to sidestep immune system

...ase, NS3/4A, chops up essential signaling proteins involved in carrying RIG-I's message to IRF-3. Without those signals, IRF-3 can't turn on the genes to make interferon, and the virus continues to replicate unimpeded. "Having identified RIG-I, now we can spend our time completely defining the signaling path...

Alcohol's effects on gene expression in the central nervous system

...re different in several brain regions which may be involved in alcohol addiction." # Researchers have identif...t appear to be responsive to alcohol include genes involved in the intracellular signaling process (which can alter how the neuron functions), neuropeptide sign...

An entropy-based gene selection method for cancer classification using microarray data

...r clinical laboratories and ideally identify genes involved in cancer-specific regulatory pathways. Here an entropy-based method is proposed that selects genes related to the different cancer classes while at the same time reducing the redundancy among the genes. Results The present study identifies a subse...

First real-time view of developing neurons reveals surprises, say Stanford researchers

... fire one by one in real time. The technical savvy involved in monitoring neurons will allow researchers to conduct experiments that were previously not possible. While the research showed neurons firing in a more mature way than expected, it also revealed that neurons take their time establishing the final ...

New insight into people who 'see' colors in letters and numbers

...e to cross-activation between adjacent brain areas involved in perceiving shapes and colors. Some synesthetes report seeing colors when listening to music, or feeling tactile shapes while tasting food. This cross-activation might develop, they theorize, by a failure of the "pruning" of neural connections betw...

Beyond lithium for bipolar disorder

... they found two other genes--PAM and GCH--that are involved in producing PACAP to be upregulated in the treated brain tissue. Brandish and his colleagues said that such findings "suggest a coordinated upregulation of genes leading to increased dopamine signaling. In the light of the recent clinical data and ...

Discovery Could Lead To Novel Approaches In HIV Treatment

...ssess how well the thymus functions. The thymus is involved in thedevelopment of T-lymphocytes, an essential component of the immunesystem. T-lymphocytes also happen to be HIV's preferred targets forinfection. The researchers then used this method to study blood samplesfrom patients that had been recently inf...

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