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Bioartificial kidney under study at MCG

...s a fraction of the work of the kidneys, which are involved in diverse functions ranging from regulating vitamin D to modulating the immune response. "Existing forms of dialysis have only replaced the ability of the kidneys to rid the body of waste products and correct abnormalities in blood chemistry; they d...

Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

... of DNA damage and accelerates the genetic changes involved in carcinogenesis. To evaluate whether reduced DNA repair capacity in the nucleotide excision pathway that fixes DNA alterations known as bulky DNA adducts is associated with breast cancer risk, Regina M. Santella, Ph.D., of the Columbia University ...

Genes In The Interferon System Important In Systemic Lupus Erythematosus

...rswho claimed that the interferon system, which is involved in the body'sdefense against viruses, etc., was also behind the autoimmune diseaseSLE. Since then they have shown the importance of the interferon systemin a number of works. This has led to the recognition of theirhypothesis in the last year, and to...

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...gned to find out whether the loss of imprinting is involved in cancer's development or just in its progression. "Most researchers, including me, expect epigenetic differences to influence progression -- whether a tumor would grow slowly or quickly, or whether it would spread," says Feinberg. "But, in this ca...

Priming embryonic stem cells to fulfill their promise

...cusing on four types of external inputsknown to be involved in triggering the differentiation of stem cells:so...but theinnovation reported today in Nature Methods involved using such amachine to spot solutions of proteins rather than DNA. The UCSDresearchers also refined ...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

...imize insulin resistance -- the other major factor involved in triggering type 2 diabetes. "In particular, so...to insulin -- a double whammy." Other researchers involved in the Joslin study included co-authors Jose C. Jimenez-Chillaron, Ph.D., Marcelino Hernandez-Valenc...

Newly-discovered class of genes determines ?and restricts ?stem cell fate

...origin for a number of tumors. Pax3 is known to be involved in some tumors, which adds evidence to the stem-cell origin for some cancers. This theory proposes that many cancers may arise from normally scarce resident stem cells that grow uncontrollably, rather than from the vast majority of differentiated cel...

Plants, animals share molecular growth mechanisms

... the study. Knowledge of the biochemical reactions involved in this process eventually may allow researchers to design plants better able to protect themselves from insects and disease. "These genes and their proteins are required for normal development and for normal cell-to-cell adhesion," Szymanski said. ...

Another Look Finds Promising Proteomics Test is Not Biologically Plausible

...onduct proteomics research,?meaning that protocols involved in these investigations should be common across laboratories so that results from one lab can be verified by others. "We are moving in that direction,?he adds. “The technology being used to develop a variety of proteomic diagnostic tests is getting ...

New species from old data

...onduct proteomics research,?meaning that protocols involved in these investigations should be common across laboratories so that results from one lab can be verified by others. "We are moving in that direction,?he adds. “The technology being used to develop a variety of proteomic diagnostic tests is getting ...

Cracking the olfactory code in bees

...onduct proteomics research,?meaning that protocols involved in these investigations should be common across laboratories so that results from one lab can be verified by others. "We are moving in that direction,?he adds. “The technology being used to develop a variety of proteomic diagnostic tests is getting ...

Signaling protein builds bigger, better bones in mice

...onduct proteomics research,?meaning that protocols involved in these investigations should be common across laboratories so that results from one lab can be verified by others. "We are moving in that direction,?he adds. “The technology being used to develop a variety of proteomic diagnostic tests is getting ...

Bacteria collection sheds light on urinary tract infections

...e at: http://ecoli.cas.psu.edu/ Other researchers involved in this project include: Amee Manges, assistant professor, McGill University; Sherry P. Smith, assistant professor, Medical College of Georgia; Meena Ramachandani, School of Public Health, Berkeley; and James Johnson, professor, University of Minneso...

Combination therapy boosts effectiveness of telomere-directed cancer cell death

... inhibition of an enzyme calledtankyrase 1 that is involved in making telomeres accessible totelomerase. The researchers found that both tankyrase 1 activity andtelomere shortening decrease the effects of telomerase inhibitors.Importantly, tankyrase inhibition enhanced telomere shortening upontreatment with a...

GATA: a graphic alignment tool for comparative sequence analysis

... inhibition of an enzyme calledtankyrase 1 that is involved in making telomeres accessible totelomerase. The researchers found that both tankyrase 1 activity andtelomere shortening decrease the effects of telomerase inhibitors.Importantly, tankyrase inhibition enhanced telomere shortening upontreatment with a...

Research on Worms Yields Clues on Aging

...partly throughtheir influence on the neural system involved in the insulin signalingpathway and partly through an independent mechanism, according toKornfeld."Our experiments show there is an important connection between neuralfunction and longevity," Kornfeld says. "We're continuing this line ofresearch to i...

Scientists find missing enzyme for tuberculosis iron scavenging pathway

... that a protein that was originally believed to be involved in tuberculosis antibiotic resistance is actually ...lycoside N-acetyltransferase that is thought to be involved in resistance to aminoglycoside antibiotics such as streptomycin. "The aminoglycoside antibiotics h...

Novel Therapy Tested in Mice Could Chase Away Cat Allergies

... brake on the release of a key chemical from cells involved in cat allergy reactions. That chemical, histamine, brings on allergy symptoms such as sneezing, wheezing, itching, watery eyes, and sometimes asthma. When a cat-allergic person touches or inhales a protein found in cat saliva or dander (small scales...

Clam embryo study shows pollutant mixture adversely affects nerve cell development

...rease in acomponent of PKA, and PKA is known to be involved in neuraldevelopment. The BCE mixture is capable of altering neural development,and alterations in neural development are thought to be a cause ofautism," says Jill Kreiling, first author of the paper and a member ofReinisch's lab. But Kreiling cauti...

Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

... the regulation and targeting of a well-known gene involved with cancer progression will have profound implications as we continue to focus on the causes of tumor development," said Richard L. Edelson, M.D., director of Yale Cancer Center. Other Yale researchers were Steven M. Johnson, Helge Grosshans and Kr...

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