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Tag: "investigators" at biology news

Chemists create 'Superbowl' molecule; May lead to better health

...nd aiding in chemical purification procedures, the investigators say. Their study was published in the Dec. 29 print issue of the journal, one of the peer-reviewed publications of the American Chemical Society, the world's largest scientific society. The superbowl molecule belongs to a class of artificial bowl-sh...

Association of herpesvirus with lung disorder questioned

Contrary to the results of a recent U.S. study, investigators in Japan found no association between a herpesviru...es are associated with genetic susceptibility, the investigators noted, but the pathogenesis of most cases is not known. Dr. Katano and colleagues conducted their r...

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

... in the form of very low-density lipoproteins. The investigators noted that in mice fed high-fat diets, the PCG-1beta mechanism actually decreased cholesterol in the liver while increasing it in the bloodstream. "Before this report, it wasn't clear what the differences were between saturated fats and unsaturated ...

A new mechanism of regulating RNA degradation

...tly transcribed or otherwise problematic RNAs, but investigators now know that it plays a major role in regulating the life span of numerous RNAs, and thus controls gene activity. To better understand what controls the NMD system, Maquat and her postdoctoral fellow, Yoon Ki Kim, Ph.D., used a critical component o...

FDA Approves Human Hookworm Vaccine for Phase I Safety Trials

...tly transcribed or otherwise problematic RNAs, but investigators now know that it plays a major role in regulating the life span of numerous RNAs, and thus controls gene activity. To better understand what controls the NMD system, Maquat and her postdoctoral fellow, Yoon Ki Kim, Ph.D., used a critical component o...

Columbia research lifts major hurdle to gene therapy for cancer

...tch for use in clinical trials withpatients. Other investigators associated with the PNAS study includeDrs. Zao-zhong Su (research scientist), Devanand Sarkar (associateresearch scientist) and Luni Emdad (postdoctoral research scientist) inDr. Fisher's group; Drs. Gregory J. Duigou (associate researchscientist) an...

Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs

...Cs in patients withperipheral vascular disease.The investigators are seeking patients in whom prior treatments,including surgery or angioplasty, have been unsuccessful, or patientsfor whom those treatments are not options. To find out more about thestudy and eligibility, call 404-712-0170....

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

...tic use in human subjects,according to research by investigators at the University of California,San Diego (UCSD) S...rally approved human embryonic stem celllines, the investigators determined that the Neu5Gc is incorporated bythe stem cells when they are grown or derived from labo...

UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims

UCLA investigators reviewed pharmaceutical ads in American medical jo.... In one of the largest studies of its kind, UCLA investigators reviewed pharmaceutical ads in American medical journals to determine what materials are cited in su...

Newly-discovered class of genes determines ?and restricts ?stem cell fate

...at a new class of genes, according to a study from investigators at the University of Pennsylvania School of Medicine. These genes ?dubbed pangenes ?can both govern a stem cell's fate and put a hold on future differentiation until the time is right. Understanding the molecular control of these genes has implicatio...

Scientists detect probable genetic cause of some Parkinson's disease cases

... in the onset of the disease. In thesestudies, the investigators found that a mutation in the gene LRRK2appears to ...a history of Parkinson's disease, forinstance, the investigators found that 34 of the 767 people who hadinherited the disease had at least one copy of the mutated ge...

Newly discovered virus linked to childhood lung disorders and Kawasaki disease

...ands or feet, and swollen cervicallymph nodes. The investigators then analyzed respiratory secretionsfrom 11 children diagnosed with Kawasaki disease and 22 childrenwithout the disease. Eight (73 percent) of the Kawasaki patients butonly one (5 percent) of the comparison group tested positive for theNew Haven coro...

Dinosaur DNA? New Patent Covers Degraded DNA recovery

...s to become degraded. "We hope this gives criminal investigators another tool to re-open cold cases or revisit crime scenes, stringing together strands of detached DNA into a genetic trail that could solve a crime or exonerate the falsely accused," says Dr. Ensley. This patent is part of a scientific progression ...

Mitochondrial DNA mutations play significant role in prostate cancer

...(<2percent) in men without prostate cancer, the investigators noted thatmen harboring these mutations are at increased risk for developingprostate cancer."We believe this study provides convincing evidence that mitochondrialmutations play an important role in prostate cancer," said Dr. Petros."This is the first...

Novel Therapy Tested in Mice Could Chase Away Cat Allergies

...Medicine, available online now. In the future, the investigators say, these promising results could lead to a new t... can be recruited to stop allergic reactions. The investigators named the chimeric molecule GFD, or gamma Feline domesticus, for its human and feline parts, explain...

Clam embryo study shows pollutant mixture adversely affects nerve cell development

... added BCE to normally developing clamembryos. The investigators used a combination of antibodies and dyes toshow the presence of neurotransmitters in single neurons. "We'veactually taken superlative three-dimensional pictures where we go rightthrough the embryo," says Reinisch. The sequence of images yields athre...

Study identifies predictors of HIV drug resistance in patients beginning triple therapy

... added BCE to normally developing clamembryos. The investigators used a combination of antibodies and dyes toshow the presence of neurotransmitters in single neurons. "We'veactually taken superlative three-dimensional pictures where we go rightthrough the embryo," says Reinisch. The sequence of images yields athre...

Gene variations explain drug dose required to control seizures

...oceedings of the National Academy of Sciences, the investigators report the first clear evidence linking variation in genes involved in the action or metabolism of the anti-epileptic drugs, carbamazepine and phenytoin, to the drugs' clinical use. The study is the first to emerge from a partnership, aimed at tailor...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

...region that restricted its activity to muscle. The investigators either injected the viral particles into the muscle or injected it intravenously in Pompe disease mice. Six weeks after muscular injection with the virus containing the muscle-restricted gene, mice exhibited high levels of the enzyme and reduced gly...

Scientists discover the cellular roots of graying hair

...ce that had noBcl2. The loss of MITF activity, the investigators say, appears to beimplicated in the mistaken differentiation of melanocyte stem cellsthat accompanies the stem cells?depletion. MITF, they conclude, seemsto play a crucial role in maintaining the supply of stem cells withinthe hair follicle, and gray...

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