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Tag: "intracellular" at biology news

Fox Chase Cancer Center scientists identify immune-system mutation

...from the thymus gland, are essential for combating intracellular viral and bacterial infections (cell-mediated immunity) and also for helping other white blood cells (B cells, derived from bone marrow) generate antibodies against foreign agents that enter the body. Other T cells are known as killer cells because t...

Bound for destruction: Ubiquitination protects against improper Notch signaling

... “juxtracrine?interactioncauses the cleavage of an intracellular region of the Notch protein,loosing it into the cy... andin reductions of the total amount of the Notch intracellular domain inthe cytoplasm of treated cells. Taken together, these results suggestedthat Nedd4 works as ...

Alcohol's effects on gene expression in the central nervous system

...esponsive to alcohol include genes involved in the intracellular signaling process (which can alter how the neuron functions), neuropeptide signaling (which modulates nerve cell activity), and myelin structure (which is needed for communication between nerve cells)," said McBride. "Gene expression profiling has al...

New SARS Protein Linked To Important Cell Doorway

...z A, Lee CA, Diamond MS, Fremont DH. Structure and intracellular targeting of the SARS-Coronavirus Orf7a Accessory Protein. Structure, January 2005, 75-85. Funding from the National Institutes of Health supported this research. ...

MSI releases 'moleculizer' - a new approach to simulation of intracellular biochemical networks

...d in our quest toprovide an accurate simulation of intracellular biochemical networks.""I've designed Moleculizer to be intuitive for biologists," said Dr.Larry Lok, a mathematician who conceived and programmed Moleculizer."Its parallel simplifications in simulation setup and output providedata in a way that is me...

DNA Recombination and Repair—A New Twist to RecA Function

... myosin and dynein, proteins that use ATP to ferry intracellular cargo along fibers made of actin or tubulin proteins. The ATP-dependent assembly of actin or tubulin fibers itself can work as a motor: for instance, the march of white blood cells toward pathogens is powered by the growth of actin filaments pushing ...

Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells

...ic differences in normal and cancer cells by using intracellular mitochondria as biomarkers for disease. This technique holds promise for detecting cancer at a very early stage and could nearly eliminate delays in diagnosis and treatment." The technique is effective because "it measures changes in the cell archit...

Tiny scaffolding allows stem cells to become working fat cells

... fibers are spun out onto a mat that resembles the intracellular matrix that bonds cells together in normal tissue. The fibers are about the size of a collagen fiber, several nanometers (a billionth of a meter) across, and provide tensile strength to support the growing tissue," Kniss said. The researchers then "...

Scientists discover that host cell lipids facilitate bacterial movement

...e cell. In the case of Listeria, we find that this intracellular pathogen can harness signals from the inner rather...he most exciting and surprising finding is that an intracellular bacteria is able to attract host cell membrane lipids to its surface and these membrane lipids facil...

Stopping smallpox in its tracks: A new anti-viral approach

...-1 signaling molecule, which normally initiates an intracellular cascade that facilitates viral replication. This study shows that drugs that interfere with erbB-1 signaling inhibit SPGF-induced viral replication and spread. The authors show that treatment with these erbB-1 inhibitors are effective in lowering mor...

New understanding of DNA repair may pave way to cancer treatments

...first to demonstrate ATF2's role in DNA repair, an intracellular process that prevents formation of genetic mutations, including those that lead to cancer. "This is the first time we've seen a protein which has been implicated in gene regulation possess an independent function--in DNA repair--while both functions...

Second messenger NAADP shows fast, dose-related impact on satiety cycle

...has "a short history compared to other traditional intracellular messengers and many aspects of this molecule remain under investigation. However the potential of this new messenger as a therapeutic target should not be underestimated," she added. ...

Motor transport in bio-nano systems

...f small vesicles which exhibit complex patterns of intracellular traffic: some vesicles travel from the cell center to the periphery and vice versa, some shuttle between different organelles or cellular compartments. An extreme case is provided by the long-ranged transport of vesicles and organelles along the axon...

Study shows how retinoic acid enters a cell's nucleus

...CRABP-II is a member of a group of proteins called intracellular lipid binding proteins (ILBP), which don't have a recognizable NLS. But now researchers have something new to look for -- folds in a molecule's structure and amino acids that flip when exposed to a hormone or a drug. Noy currently is working with an ...

USC researchers determine mechanism of action of chemotherapy drug

...s that agents that disrupt metabolism and increase intracellular zinc levels have potential applications as anticancer therapeutics." ...

Retroviral resistance gene found

...ct that the overexpression of FEZ1 interferes with intracellular trafficking of the viral preintegration complex and traps the viral DNA in the cytoplasm. We hope that learning more about this transport machinery might reveal a new target for antiviral drugs in the treatment of HIV-1 disease." ...

Pinpointing a culprit molecule in Alzheimer's disease

...te we have little evidence for the accumulation of intracellular Ab in these mice; thus, they provide an excellent tool to study the effects of secreted Ab independently of APP transgenes." McGowan et al.: "Aß42 is Essential for Parenchymal and Vascular Amyloid Deposition in Mice" Publishing in Neuron, Vol. 47, J...

'Jumping genes' contribute to the uniqueness of individual brains

...A, the transposable L1 elements were thought to be intracellular parasites or leftovers from our distant evolutionary past. It has been known for a long time that L1 elements are active in testis and ovaries, which explains how they potentially play a role in evolution by passing on new insertions to future gener...

A molecule impedes the destruction of the 'Brucella' bacteria

...gy scientific magazine. Brucella is a model of an intracellular parasite, a category that includes other important bacteria, such as those of tuberculosis or legionelosis. Brucella penetrates the macrophages within membranous vesicles that are not fused with lysosomes (structures containing cellular products nece...

Chemical 'band-aid' prevents heart failure in mice with muscular dystrophy

...to allow the simultaneous measurement of force and intracellular calcium concentration in individual myocytes as they are stretched. Yasuda's device uses microcarbon fibers stuck by electrostatic attraction to each end of a single cardiac myocyte. As the myocyte is stretched between the carbon fibers, a transmitte...

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