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Columbia research lifts major hurdle to gene therapy for cancer

...trated thatthe technique works by incorporating it into a specially designedvirus. The virus eradicated prostate cancer cells in the lab and inanimals while leaving normal cells unscathed. Genetherapy based on the new technique should also be effective for a widerange of tumors - such as ovarian, breast,...

Dysentery uses 'sword and shield' to cause infection

...lls by using a secretion system to inject proteins into human cells, (the sword), while lipopolysaccharide...ses a Type III secretion system to inject proteins into human cells. This causes the cells to become inflamed, resulting in symptoms of dysentery, such as b...

Priming embryonic stem cells to fulfill their promise

...nvented a process to help turn embryonicstem cells into the types of specialized cells being sought as pos...s must first be coaxed todifferentiate, or mature, into precursors of specialized cell typesfound in the body.Embryonic stem cell differentiation is complex...

Growth in the sea comes down to a struggle for iron

Scientists know that injecting iron into some major regions of the oceans can stimulate the...tudy the ecological consequences of injecting iron into the ocean. For more than a century, oceanographers puzzled over the low abundance of phytoplankton ...

New binding target for oncogenic viral protein

...t regulates cell division may lead to new insights into the pathways that cause cancer. This is an important step to designing new cancer treatment strategies that target these pathways," concluded Dr. Clurman. ...

Lack of enzyme turns fat cells into fat burners

..., appears to turn the adipose or fat cells of mice into fatburners, explaining in part why the animals can eat more and weigh lessthan their normal counterparts, said Baylor College of Medicineresearchers.The report that appears online today in the Proceedings of the NationalAcademy of Sciences. "Westudi...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

...hich lasts three weeks. They separated the mothers into two groups. The control group ate as much chow as ...to its effect. Without insulin, glucose cannot get into cells to provide energy. Normally, insulin levels rise or drop in response to glucose levels, keepi...

Controversial drug shown to act on brain protein to cut alcohol use

...ug was administered either by injection ordirectly into the same brain region where GDNF levels were shown toincrease.The research also showed that Ibogaine was quite effective inpreventing relapse, or "falling off the wagon" -- the vulnerability ofrecovered alcoholics or addicts to return to uncontrolled...

Neuronal 'traffic jam' marks early Alzheimer's disease

... using human embryonic stem cells to differentiate into neurons in culture. Their goal is to alter those neurons genetically by introducing mutations know to cause Alzheimer's disease in people, to then test for transport defects, and then study whether those defects produce pathology similar to that seen...

Termites feed through good vibrations

...nfestations in homes and also may provide insights into the "cocktail party effect" of signal processing ?... vibrations made by termites from the large blocks into small blocks and found that the termites switched their preference to the large blocks. Prof Lai cre...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

...c stem cells that had been allowed todifferentiate into embryoid bodies (EB), which is the first step inpr...dietaryproteins from animals could be incorporated into cells lining thestomach and colon, organs where consumption of red meat has beenassociated with risk...

Elusive HIV shape change revealed; Key clue to how virus infects cells

... these compounds work and hasten their development into drugs. "The findings also will help us understand why it's so hard to make an HIV vaccine, and will help us start strategizing about new approaches to vaccine development." The studies, performed in the Children's Hospital Boston Laboratory of Molec...

Mouse brain cells rapidly recover after Alzheimer's plaques are cleared

...gs were least likely to heal. Brendzaplans to look into whether additional treatment can prompt theirrecovery.Holtzman and Brendza plan to continue using the mouse model to studydisease treatments and the cellular abnormalities caused by theirAlzheimer's-like condition."For example, we'd like to know what...

Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer

...nome in its transition from a free-living organism into a parasite of the human gut. At the same time, sci...tudy of relatively recent horizontal gene transfer into a protist, scientists report evidence in the DNA sequence that E. histolytica likely picked up a sig...

Key molecule in plant photo-protection identified

...gs were least likely to heal. Brendzaplans to look into whether additional treatment can prompt theirrecovery.Holtzman and Brendza plan to continue using the mouse model to studydisease treatments and the cellular abnormalities caused by theirAlzheimer's-like condition."For example, we'd like to know what...

Antarctic ice shelf retreats happened before

...the ice shelf retreated, allowing the sea to flood into the lake. The ice shelf didn't reform until 1500 years later, and has been present ever since. The findings are particularly relevant for other studies on the West Antarctic Ice Sheet where scientists have found that a relatively warm current, Circu...

Newly-discovered class of genes determines ?and restricts ?stem cell fate

...tem cells in the skin could be the cells that turn into skin cancers like melanoma. Understanding stem cell biology may therefore be important for developing new therapies for cancer. Adult resident stem cells have been identified in many types of organs and may be a potential reservoir for tissue regene...

Tiny particles could solve billion-dollar problem

... cost of bringing its 1,400 TCE-contaminated sites into EPA compliance at more than $5 billion. The typic...atalysts or microorganisms that break the TCE down into less toxic or non-toxic constituents. In general, chemical catalysis offers faster reactions times t...

UW's Rosetta software to unlock secrets of many human proteins

...fcomputer downtime.The information will be entered into a publicly accessible database,which scientists can then use to conduct research into new drugs andtreatments.Rosetta works by virtually folding protein sequences into thousands ofpossib...

Plants, animals share molecular growth mechanisms

...angeable, and Szymanski's research team is delving into how this affects the growth process. "DIS3 has two ends that are common in both plant and animal proteins," he said. "But DIS3 has a very large segment in the middle that is specific to plants. We'd like to know if this section is important and whet...

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