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Tag: "interplay" at biology news

Largest study of human 'interactome' reveals a novel way

...st detailed human "interactome" yet describing the interplay of proteins that occur in cells during health and disease. "Genes are important because they are the blueprints for proteins, but proteins are where the action is in human life and health," says Akhilesh Pandey, M.D., Ph.D., an assistant professor ...

Patterns in genome organization may partially explain how microbial cells work

... organization as well as upon genome content. That interplay between organization and function can't be ignored if we want to gain a better fundamental understanding of how a microbial cell works." ...

Clock molecule's sensitivity to lithium sheds light on bipolar disorder

... such as obesity and diabetes. "There is a dynamic interplay between circadian rhythms and metabolism," Lazar says. "You don't eat while you are sleeping, and the body needs to take this into account." Study co-authors are Lei Yin and Jing Wang, both from Penn. The research was funded by the National Institut...

Multi-million pound UK Biobank underway

...tudy in depth, in decades to come, how the complex interplay of genes, lifestyle and environment affect our risk of disease. Because it will involve thousands of people who eventually go on to contract each particular disease UK Biobank will provide a uniquely rich resource that allows researchers to identify ...

New mechanism for essential genome-wide gene silencing identified

... of that." The research team also noted a dynamic interplay between the addition of a SUMO protein to a histone ?sumoylation ?and the addition of either an acetyl group or a ubiquitin protein to a histone. The processes appear to be mutually exclusive. "Acetylation and ubiquitylation have both been shown in ...

Two NIH initiatives launch intensive efforts to find roots of common diseases

...he environmental contributors to sickness, and the interplay among genes and environment. There is not a moment to be lost." GEI will have two main components: a laboratory procedure for efficiently analyzing genetic variation in groups of patients with specific illnesses and a technology development program...

Genetic tug of war determines sexual differentiation

...that vertebrate sex determination results from the interplay between these two opposing signals." The researchers published their findings in the May 22, 2006, issue of the journal Public Library of Science-Biology. Their research was supported by the National Institutes of Health. In mammals, a fertilized e...

Genetic snooze button governs timing of spring flowers

.... What they have found reveals some of the complex interplay of genes and environment and provides hints that, one day, it may be possible to exert precise control over flowering, a process essential for plant reproduction and fruiting and that has enormous implications for agriculture. Flowers are the repro...

Researchers attack tumor cells by exploiting dependency on sugar metabolism

... on the association between tumor survival and the interplay between glycolytic phenotype and mitochondrial metabolism. The researchers used a sophisticated genetic technique to reduce levels of lactate dehydrogenase A (LDH-A), an enzyme required for the glucose to lactate pathway that is elevated in human bre...

Key gene controlling eye lens development identified

... the eye, and gives us important insights into the interplay of genes during this time," said Wei Liu, Ph.D., a postdoctoral fellow in Oliver's laboratory. Lui is first author of the paper. ...

Most widely used organic pesticide requires help to kill

...ually all animals, including humans, depend on the interplay of numerous species of bacteria that, beginning at birth, routinely colonize the stomach and intestines. The caterpillars of moths and butterflies, for example, have anywhere from seven to twenty species of gut bacteria. Humans have between five hund...

For crickets, parasitic flies can stop the music

...or, are of interest because they shed light on the interplay between the powerful evolutionary forces of sexual...ann said the answer may have to do with the subtle interplay between the density of flies, the density of crickets and the presence of other predators that prey ...

Altered perception of reward in human cocaine addiction

...ocaine-addicted individuals. "The dysfunctional interplay between reward processing and control of behavior observed in these studies could help to explain the chronically relapsing nature of drug addiction," Goldstein said. "Our results also suggest the need for new clinical interventions aimed at helping ...

From a lowly yeast, researchers divine a clue to human disease

...other researchers can use to better understand the interplay of the protein and gene regulation in human disease. "This work gives a method to start examining what the defect is in humans," he says. In the past, says Brow, researchers looked at regulation of individual genes but not the whole genome at onc...

Key to zebrafish heart regeneration uncovered

...ion of a zebrafish's heart is removed, the dynamic interplay between a mass of stem cells that forms in the wound and the protective cell layer that covers the wound spurs the regeneration of functional new heart tissue, Duke University Medical Center scientists have found. The scientists further discovered t...

Genes and genius: Researchers confirm association between gene and intelligence

...ttracted the attention of people interested in the interplay of genes and environmental influences. Early studies of adopted children, for example, showed that when children grow up away from their biological parents, their IQs are more closely correlated to biological parents, with whom they share genes, than...

Scientists uncover new target in cancer mutation puzzle

...n. Since then, his work has focused on the complex interplay necessary for malignancy. And while other researchers, for example, are seeking ways to normalize a faulty gene such as p53, which is involved in half of all human tumors, Land's research group is taking the opposite approach. They are looking for wa...

Using brain scans, researchers find evidence for a two-stage model of human perceptual learning

... belongs to "food." They describe it as a complex interplay between neurons that process stimulus shape ("bottom-up") and more sophisticated brain areas that discriminate between these shapes to categorize and "label" that information ("top-down"). A human can't function without the ability to sort betwee...

New molecular pathway could reveal how cells stick together

..., that gets cut by MMP. Now she is working out the interplay between MMPs and ninjurin, with the goal of characterizing this previously unknown pathway by which cells signal to each other. Ninjurin is anchored to the surface of cells, but after being cut by MMP, a ninjurin segment travels to adjacent cells ...

Scientists find potential 'off-switch' for HIV virus

...tail off the Tat protein, rendering it silent. The interplay between p300 and SirT1 comprises the resistor and can effectively keep the virus in its dormant phase. "SirT1 reduces the strength of the signal to replicate," Weinberger said. "It may prove to be the key part of the resistor in the circuit, as o...

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