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Tag: "interferon" at biology news

Novel therapy combinations gain ground in treating hepatitis

...ains of hepatitis C that do not respond to current interferon therapies and have no other effective treatment op...ron) plus ribavirin (RBV) versus pegIFN (pegylated interferon alfa 2a) plus RBV for 72 weeks in patients with a prior relapse to 48 weeks of treatment. A total o...

T cells activated to fight HIV basis for dendritic cell therapeutic vaccine

... substance that binds to certain immune cells, and interferon gamma were added to dendritic cells. In the study, white blood cells called monocytes were obtained from both HIV patients and individuals not infected with the virus. In the laboratory, the researchers coaxed them to differentiate into mature de...

Study details hepatitis C ability to block immune system response

...innate immune response involving release of type 1 interferon (IFN-? and IFN-?). In turn, type 1 interferon stimulates the production of a family of what are known as IFN stimulated genes that have a multitud...

Failure of 'scout cells' may lead to cancer in transplant patients

... body of TGFb and a second immune substance called interferon gamma (IFNg) might influence development of the cancer. The study showed that some people have a normal genetic difference that causes them to have lower levels of IFNg in the body and others to have higher levels. The researchers then injected...

Researchers find 'secret weapon' used by SARS virus

...e messenger RNA instructions sent from DNA to make interferon beta, which is crucial to host immunity," said UTMB professor of microbiology and immunology Shinji Makino, senior author of a paper on the discovery to be published online the week of August 7 in the Proceedings of the National Academy of Sciences. ...

Researcher studies, treats military with 'silent disease'

...nt--24 to 48 weeks of a once-a-week injection with interferon and several pills of ribavirin each day--are what Sjogren speculated would cause a decrease in quality of the volunteers' lives. "The medications are tough to take," she said. On initial questionnaires, study volunteers reported that they were depre...

Statins stop hepatitis C virus from replicating

...The standard treatment is a combination therapy of interferon and ribavirin, which is only effective in about 55...the statin was used alone. Again, fluvastatin plus interferon exhibited the strongest effect. "We clearly demonstrated that co-treatment of interferon and fluvast...

Selectively blocking inflammatory signals may protect mice from MS

...system damage, 18 out of 20 mice exposed to higher interferon levels developed difficulty walking, including mil...of birth. Only four out of 20 mice with both high interferon levels and the SOCS1 gene had symptoms. On autopsy, mice with high interferon levels in the nervo...

Inheriting a tendency to brain infection

...d and mildly mentally retarded. The link between interferon production and the disease suggests a new strategy...clovir, and with type I interferon, to replace the interferon they lack if they have the mutation, said Casanova. That hasn't happened yet, although patients susc...

Molecular 'on/off switch' controls immune defenses against viruses

...tease to disrupt the signaling process, preventing interferon production and allowing viral replication. Just how RIG-I signaling is normally regulated, however, hadn't been known. In the current study, UT Southwestern researchers found that RIG-I and LGP2 each contain a repressor domain, a sort of docki...

Research holds promise for herpes vaccine

...a warning to neighboring cells. This warning -- an interferon response -- causes neighboring cells to enter "an anti-viral state" akin to putting on a suit of armor, Halford said. However, herpes produces a protein, ICP0, that tricks every infected cell into destroying its own armor. Once the cell's armor is...

New test helps identify hepatitis C patients at high risk of developing cirrhosis

...ng. Treatment includes weekly injections of alpha interferon along with the drug ribavirin, which can cost more than $30,000 per year and can cause flu-like symptoms, nausea, depression and other side effects. And only half of patients undergoing this therapy will be cured of the infection. Nearly 4 mill...

Researchers find hepatitis A and hepatitis C attack same protein to block immune defenses

... sequence of signals ending with the production of interferon beta?a potent inhibitor of virus replication. Recent research has shown that hepatitis C generates a protein called NS3/4A that chops up MAVS, interfering with immune signaling and possibly providing the cover the virus needs to survive so long in th...

Mechanisms involved with tumor relapse identified

...the immune system and cancer cells have identified interferon gamma as one of the signaling proteins involved wi...use model of breast cancer, researchers found that interferon gamma, a cytokine or chemical messenger that is produced by cells of the immune system upon activati...

Veterinary scientists explore poultry virus as cancer killer

... prostate cells. Normal, healthy cells have an interferon antiviral system that activates upon infection wit...Dr. Subbiah. Cancer cells, however, have defective interferon antiviral systems, he said. NDV utilizes the defects to replicate in the diseased cells. The replica...

Herpes infection may be symbiotic, help beat back some bacteria

... increasing production of a protein hormone called interferon gamma," Virgin says. "This is a signaling hormone ...dy." Other scientists previously had shown that interferon gamma helps the immune system fight off some strains of bacteria. This led Virgin and his colleagues...

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