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Tag: "interfering" at biology news

Heavy smoking cuts women's chance of pregnancy -- even with donated oocytes

... Soares, "and although we controlled for all known interfering variables, it is possible this is not a real association. What would confirm it as a real association is to find it still applies in a large number of cases. However, if it is confirmed as a real association it suggests that, paradoxically, tobacco c...

Peering into the shadow world of RNA

...One of these suppression mechanisms involves short interfering RNA, or siRNA, a form of non-coding RNA that specifically targets and inactivates the stretch of DNA from which it originated. In the case of transposons, this would effectively limit their ability to act, thus protecting the genome from potential di...

Researchers seek to design first treatment for neuroAIDS

... suicide. Maggirwar was the first to theorize that interfering with this pathway could protect against neuroAIDS, and to prove his theory using sodium valproate and lithium, existing epilepsy drugs that turned out to be GSK-3b inhibitors. Gelbard and Maggirwar; along with received in 1999 one of the first gran...

Reactivated gene shrinks tumors

...now under investigation, known as nutlins, acts by interfering with MDM2, an enzyme that keeps p53 levels low. In follow-up studies, the MIT researchers are looking at other types of cancer, such as epithelial (skin) cancer, in their mouse model, and they plan to see if the same approach will also work for tu...

Short chromosomes put cancer cells in forced rest

...ggest new ways of preventing or treating cancer by interfering safely with telomerase and the cell-suicide system....

Batten down the hatches against HIV

...nvolved is the co-receptor CXCR4. The use of short interfering RNA strands allows the CD4 and CXCR4 genes of the T-cell to be shut off. The T-cell then strops producing these receptors and the virus cannot find any points of attack on the surface of the cell. This could significantly slow down an HIV infection, ...

Knocking out survival protein could aid leukemia treatment

... The investigators placed molecules called small interfering RNA (siRNA) inside the cells and found that the tiny molecules greatly reduced the amount of the survival protein, causing many of the cells to die. The effect was the same even in cells that came from patients with advanced cancer or from patients w...

Scientists uncover new target in cancer mutation puzzle

...roach. They are looking for ways to stop tumors by interfering with features of cancer cells dependent upon p53 and Ras mutations. For cancer to develop, several mutations must arise and collaborate within a single cell. Ras and p53 mutations are particularly dangerous, implicated in colon, pancreas, lung and...

Protein found to shield pancreatic cancer cells from self-destruction

...y targeted TG2 with a tiny molecule known as small interfering RNA tailored to shut down expression of the protein. In both cases, the result was a drastic reduction of TG2 expression (up to 94 percent) and telltale signs of autophagy in the cancer cells, which became riddled with cavities called vacuoles. ...

Molecular signature may identify cisplatin-sensitive breast tumors

...showed that the protein stimulates tumor growth by interfering with p73’s normal ability to induce cell death. Cisplatin was found to break up the binding of p63 to p73 and reactivate the cell-death process. "The most important finding was that, if the tumor cells did not express both p63 and p73, the cells w...

Trojan horse strategy defeats drug-resistant bacteria

...d eliminate life-threatening infections in mice by interfering with a key bacterial nutrient, according to research led by a University of Washington scientist. The joint project, conducted at the UW, the University of Iowa, and the University of Cincinnati, will be featured in the April 2 issue of the Journal o...

Researchers find hepatitis A and hepatitis C attack same protein to block immune defenses

...erates a protein called NS3/4A that chops up MAVS, interfering with immune signaling and possibly providing the cover the virus needs to survive so long in the liver. Now, Lemon and his group have demonstrated that hepatitis A does the same thing with a different protein, known as 3ABC. "Hepatitis A never man...

Gene therapy for blindness clears hurdle in mice

...ting the eye with a bit of genetic material called interfering RNA, which helps disable the gene. Normally the... UF Genetics Institute researchers engineered the interfering RNA into a virus, which in turn was injected below the retinas in more than a dozen normal mice. Ana...

Cancer tip -- Nanoparticles can damage DNA, increase cancer risk

...ses, yet they are large enough to cause trouble by interfering with normal cell processes, researchers at the University of Massachusetts say. Such nanoparticles are currently in use in electronics, cosmetics, and chemical manufacturing, among others industries. Because of their extremely small size, they can b...

Technology reveals 'lock and key' proteins behind diseases

...s device gives us insights as to what proteins are interfering with this process." iMYTH works by scanning cells to reveal proteins that fit with the transporters, the only screening system sophisticated enough to work with delicate membrane proteins. Simply, if two proteins interact in iMYTH, they will stain...

Bacteria control how infectious they become, study finds

...es is, in a sense, a genius way to prevent it from interfering with NusG,?Artsimovitch said. “It seems that the only genes that RfaH can't regulate are those controlled by NusG.? Bacteria can survive without RfaH, but not without NusG. Yet without RfaH, bacteria lose the ability to infect. In previous laborato...

RNA splicing factor implicated in ovarian tumor cell growth

...earchers in the UIC College of Pharmacy found that interfering with the production of a splicing factor can inhib...show that knocking down PTB expression with small, interfering RNA "substantially impairs ovarian tumor cell growth, colony formation and invasiveness." The res...

Scientists identify pancreatic cancer stem cells

...cally targets pancreatic cancer stem cells without interfering with normal stem cell function." While such a drug has not been developed, ongoing research suggests it is possible to do so, she added. The study also advances the emerging notion that stem cells may lie at the heart of some, if not all, cance...

Dinosaur hearing, listening to muscle noise, quieter cubicles

...improved audibility conditions for sounds, without interfering with the MRI's scanner's image quality (4pPP16). TURNING VOICE LESSONS INTO A SCIENCE Drawing from knowledge of acoustics and human anatomy, researchers in session 2pMUa will discuss the latest ideas for teaching voice students to improve the...

Students invent protective pouch to enhance cell therapy

...where they can provide effective treatment without interfering with healthy body functions. Arepally and Bulte have overcome some of these hurdles by working with semi-permeable alginate microcapsules ?tiny spheres that surround the injected cells and protect them from the body’s immune system. At the same t...

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