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Tag: "interfering" at biology news

'Genetic network' guards against lethal DNA damage

...0 other genes can be deleted from the cell without interfering with the cell's growth. A major goal of the Hopkins team is to determine which of the non-essential genes interact with each other, said Boeke. All such pair-wise combinations of the 5,000 non-essential genes in the yeast genome would require about ...

Gene thwarts some pathogens, gives access to others, could save crops

...t may promote susceptibility to other pathogens by interfering with other defense strategies of the plants." The research team first looked at normal plants and then at the BIK1 mutant when they began to study the effect of different hormones on plant growth and pathogen defense, Mengiste said. The scientists w...

Revolution in the fight against cancer & viruses

.... "We've exploited this process by creating short interfering RNA, or siRNA, that are being developed into drugs to fight viruses and cancer," he said. "We've now taken this a step further and worked out how we can create siRNA with different cellular properties to target different diseases." While previous st...

RNA interference stops colon cancer spread in mice

...sts were the first to use what are known as "small interfering RNAs" to block the spread of human colorectal cancer cells implanted in laboratory mice. Small interfering RNAs (siRNAs), first described in 2001, are tiny bits of genetic material that can prevent the trans...

Fatty spheres loaded with siRNA shrink ovarian cancer tumors in preclinical trial

...l, demonstrates a potent delivery system for short interfering RNA (siRNA) to attack cancer, says senior author A...gy and Cancer Biology at M. D. Anderson. "Short interfering RNA is a great technology we can use to silence genes, shutting down production of harmful proteins,...

UC Davis researchers reveal apples' protective ways

...was able to protect cells from damage and death by interfering with communication between cells. The current findings appear in the latest issue of Experimental Biology and Medicine.Earlier studies have shown that flavonoids--which are found in chocolate and green tea, as well as other fruits and vegetables--be...

Pathway toward gene silencing described in plants

... nucleus, and it involves short RNAs, called small interfering RNAs -- siRNAs." Those little tykes, just 24 nuc...like 3 protein, DCL3 then chops the RNA into small interfering RNAs (siRNAs). Along comes ARGONAUTE4 (AGO4), which grabs hold of the siRNAs while also binding to ...

Researchers attack tumor cells by exploiting dependency on sugar metabolism

...ractive and potentially well-tolerated approach to interfering with tumor growth. Normal cells produce most of the ATP they need to power cellular functions through an oxygen-dependent process known as oxidative phosphorylation. In contrast, cancer cells commonly switch to what is known as a "glycolytic phenot...

Bacteria have their own immune system protecting against outside DNA

...at the H-NS "immune system" may be responsible for interfering with the expression of human genes in bacteria. "Having a better understanding of this system could help the biotech industry make recombinant proteins more efficiently," said Fang. "More foreign protein can be produced in bacteria that don't have ...

Diabetes research takes wing thanks to long-lived fruit fly

...nding has opened up an untapped route for possibly interfering with the disease process that underlies diabetes. "Obesity is on the rise dramatically, and after decades of increasing life span among people in the United States, there is talk that life expectancy is actually expected to fall soon, largely due to...

Interfering RNA silences genes in 'slippery' immune cells

...ells have previously been difficult to modify with interfering RNA, being more mobile than other cell types that ...conventional technique, which uses synthetic small interfering RNA but is very expensive and in short supply. We expect our technique to expand the toolbox for sci...

Epstein-Barr virus might kick-start multiple sclerosis

...in central nervous system injury and inflammation, interfering with them could prove effective." ...

UWM brain research supports drug development from jellyfish protein

...hout it. But too much of it leads to neuron death, interfering with memory and contributing to neurodegenerative diseases. "There are ways in which cells control the influx of calcium, such as sequestering it by binding it with certain proteins," said Moyer. "If it weren't for these proteins, the high level of...

How does a zebrafish grow a new tail?

...eration in mammals and man. So, if we find ways of interfering with the function of Wnt5b, we might be able to promote regeneration." Moon added that, because the same genes for turning on and turning off growth and development are found in humans, and drugs exist that can regulate this pathway, the findings a...

Detecting explosives with honeybees

...d detect explosives in the presence of potentially interfering agents, such as lotions, motor oil, or insect repellant. In addition, the team studied structural units in the honey bee's antenna and looked for biochemical and molecular mechanisms that could advance their ability to be trained and retain their tra...

Zinc plays important role in brain circuitry

...sts. This work provides a clear demonstration that interfering with zinc modulation of a synaptic pathway leads to a significant alteration in the phenotype of the animal." The three scientists added that the finding "puts a nice dent in the zinc armor, which held firm for more than 50 years." ...

Two central mysteries in genome inheritance solved at UCSD

...spindle microtubule polymers during this time, and interfering with this connection ?using drugs that bind to microtubule polymers ?is a common chemotherapy strategy used to target and curtail rapidly dividing cancer cells. While scientists have known that breakdown of this connection could stop the proliferati...

Molecular structure reveals how botulinum toxin attaches to nerve cells

...In the body, the toxins bind to and enter neurons, interfering with nerve transmission and disrupting the communication between the nerve and muscle fibers throughout the body. Poisoning with botulinum toxins leads to an often-fatal paralysis, which is one reason they are considered among the highest biodefense ...

Rising ocean temperatures, pollution have oysters in hot water

...ters from obtaining enough oxygen or whether it is interfering with the animal's ability to use the oxygen it obtains, Lannig said. These experiments on oyster physiology could be important to save what is left of this ecologically important population. ...

Researchers identify new weapon to fight deadly bacterial sepsis

...ity with pharmacological inhibitors or using small interfering RNAs (pieces of genetic material that specifically stop the production of particular cellular proteins) to prevent the cells from producing the enzyme in the first place, the researchers demonstrated that aldose reductase is essential to that cycle. ...

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