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Tag: "interfering" at biology news

Virus uses tiny RNA to evade the immune system

...f tiny RNA molecules can silence specific genes by interfering with larger messenger RNAs (mRNAs). That interference prevents mRNAs from making proteins. Scientists do not know which genes are hushed by the microRNAs in people, but the new study bolsters growing evidence that the little molecules can play import...

Einstein researchers identify new way that bacteria develop resistance to antibiotics

...includes ciprofloxacin (Cipro), work against TB by interfering with the microbe's ability to reproduce itself. Specifically, the drugs target an enzyme called DNA gyrase, which helps untwist bacterial DNA during replication. However, TB has been developing resistance to fluoroquinolones due to their increasing u...

Researcher at UGA College of Veterinary Medicine identifies new way of combating viral diseases

...ola, HIV-1, and measles viruses. "We believe that interfering with the Rab9 pathway interferes with the ability of the viruses to exit the cell, thereby dramatically decreasing the ability of the virus to spread rapidly and produce infection," Hodge said. Because these viruses depend heavily on this exit pathw...

Dendritic cells offer new therapeutic target for drugs to treat MS and other autoimmune disease

...ures and mice suggest that blocking the pathway by interfering with a blood cell growth gene, known as FLT3, targets an immune system cell often ignored in favor of T-cell targets in standard therapies. FLT3, which controls the development of healthy blood cells, was identified as a treatment target in patient...

New molecule may aid in production of biofuels and fungi-resistant plants

...umanity. For example, insects might be combated by interfering with their chitin metabolism. Insect viruses need to degrade insect chitin for infection. Fungi may also be combated by degrading the chitin in their cell walls." More than one billion tons of chitin are produced by insects, fungi, and marine organi...

Researchers offer proof-of-concept for Altered Nuclear Transfer

...ique called RNA interference, or RNAi. Here, short interfering RNA (siRNA) molecules are designed to target an individual gene and disrupt its ability to produce protein. In effect, the gene is shut off. Jaenisch and Meissner designed a particular form of siRNA that shut off this gene in the donor nucleus and th...

Small molecule inhibitor of cholera discovered

... traditional antibiotics kill bacteria outright by interfering with processes essential for their survival, the new agent blocks production of bacterial proteins that cause the severe diarrhea associated with Vibrio cholerae infection. "What we have done is made a custom, organism-specific antibiotic against V...

Sickle cell disease corrected in human models using stem cell-based gene therapy

...herapeutic globin gene harboring an embedded small interfering RNA precursor designed to suppress abnormal hemogl...ene, consisting of the gamma-globin gene and small interfering RNA specific for beta S-globin, the globin mutant chain that causes sickle cell disease. "An innov...

Yale participates in global human genome initiative

...man genome siRNA library, or compilation of short, interfering ribonucleic acid sequences. The library is designed to determine when individual genes are functioning. It uses a format that is accessible to researchers for detailed analysis of individual genes, gene families and metabolic pathways. The siRNA seq...

Federal grant funds research on novel HIV therapy

.... Douglas, "and we are testing the hypothesis that interfering with substance P receptors may reduce neurological injury from HIV infection." Project 3, led by Andrew A. Lackner, Ph.D., D.V.M., director of the Tulane National Primate Research Center, will test whether NK-1R antagonists are safe in animals infe...

Limiting the damage in stroke

...istry and behavior of the cell. Most drugs work by interfering with molecules that play important roles within these networks. Scientists knew that NF-kB signaling was active in neurons, but its function was unclear. "We had some evidence that in nerve cells, it could trigger a self-destruction program called a...

Texas scientists discover how a hepatitis C protein promotes liver cancer

...crucial for suppressing the development of tumors, interfering with its ability to control cell proliferation," Lemon said. "By knocking out this 'tumor suppressor' and promoting the proliferation of liver cells, this viral protein is setting up the liver for cancer." According to the federal Centers for Diseas...

Neurons find their place in the developing nervous system with the help of a sticky molecule

...d in utero surgery on embryonic mice ?injecting an interfering RNA molecule into the lateral ventricle, a fluid-f... discovered that nearly all neurons containing the interfering RNA were stalled in aberrant deeper locations, indicating that loss of MDGA1 protein had stymied the...

New compound protects against liver cancer

...ler. "CDDO-Im can also inhibit cancer formation by interfering with this inflammatory process." Because it can stimulate the body's defense mechanisms at such low doses, Kensler believes that CDDO-Im is an excellent candidate for cancer prevention in humans. "If this compound can produce such a potent and drama...

Sea coral's trick helps scientists tag proteins

...ndra is small enough to highlight proteins without interfering with their folding or function. And the researchers have demonstrated that it can switch shades at the body temperature of birds and mammals, which are popular research models. Its usefulness is further enhanced by the fact that it stays red for long...

Chemical guidance of T cells leads to immunologic memory and long-term immunity

...ls receive best as a signal, says Dr. Germain. By interfering with the action of these chemokines, he and his colleagues demonstrated that CD8+ T cells lost their ability to home in on the dendritic cells interacting with the helper T cells. The result was a marked impairment of memory cell generation. Thes...

MiRNA fingerprint identified in platelet formation

...des in length ?also regulates protein synthesis by interfering with mRNA's original instructions. They now know that miRNA helps to regulate many key biological processes, including cell growth, death, development and differentiation. Dr. Carlo Croce, director of Ohio State's Human Cancer Genetics Program, was ...

Gene-specific Ebola therapies protect non-human primates from lethal disease

...cientists have developed a successful strategy for interfering with Ebola virus infection that protected 75 percent of nonhuman primates exposed to the lethal disease. This is the first successful antiviral intervention against filoviruses like Ebola in nonhuman primates. The findings could serve as the basis fo...

Mice lacking social memory molecule take bullying in stride

...sants restores social approach behaviors partly by interfering with the cascade of activity triggered by BDNF as the organism adapts to experience. The researchers say the study "suggests new directions for antidepressant drug discovery." ...

Scientists re-engineer a well-known antibiotic to counter drug resistance

...he VRE actually alters these cell-wall components, interfering with the drug's ability to bind to the bacterium. According to the Centers for Disease Control, VRE were first reported in 1986, nearly 30 years after the introduction of the drug. The study, published in the Journal of the American Chemical Society,...

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