interference 2 3

Tag: "interference" at biology news

Virus uses tiny RNA to evade the immune system

...terfering with larger messenger RNAs (mRNAs). That interference prevents mRNAs from making proteins. Scientists do... and cause disease. When scientists found that RNA interference appeared to be a basic and widespread gene regulatory mechanism, "it became clear that such a fundam...

Hunt for human genes involved in cell division under way

...ted. The scientists will use a method called 'RNA interference (RNAi)' where chemically synthesized RNA molecules are used to target and silence each human gene. About 22,000 genes will be suppressed and their impact on cell division monitored by live cell microscopy to understand each gene's role in cell divisi...

Once given 'no respect,' cells' tiny RNAS take driver's seat

...lar machinery that deals with what is known as RNA interference -- a biological phenomenon that specifically prevents RNA from being used to make proteins. Accompanying the Hopkins paper are two reports looking specifically at microRNAs in cancer -- one in humans, one in mice. One report shows that human tumors'...

Brain size may depend upon how neural cells are cleaved

...in the developing mouse brain. They saw a dramatic interference with orientation of cell cleavage to overproduce "postmitotic" neurons -- cells that could no longer divide -- at the expense of progenitor cells, which could still divide. "This observation led us to want to further test whether impairment of Gβγ ha...

Researchers feed tiny pills of RNA to planarians to identify genes essential for regeneration

...al Cell, employed the first large-scale use of RNA interference (RNAi) to silence planarian genes to identify their role in the worm's biology, according to Alejandro Sánchez Alvarado, Ph.D., principal investigator and U medical school associate professor of neurobiology and anatomy. The U team's work shows that ...

Molecular steps involved in the creation of gene-silencing microRNAs identified

...ttar. "The tantalizing implication is that the RNA interference pathway may play a significant role in HIV replication. TRBP has also been identified as a tumor suppressor, which suggests still other connections to be explored." The lead authors on the Nature study are Thimmaiah Chendrimada, Richard I. Gregory, ...

U. Iowa researchers improve Huntington's disease symptoms in mice

...ngton's disease (HD). Using an approach called RNA interference (RNAi), the scientists reduced levels of the disea...direct and target the symptoms of the disease. RNA interference gives us the first opportunity to attack the fundamental problem and reduce protein expression from ...

Ancient immune defense mechanism is no match for HIV-1

...lementary target RNA. This process is known as RNA interference (RNAi) and can silence the ability of a virus to successfully reproduce itself. Although this mechanism has been artificially manipulated to selectively inhibit specific genes in mammalian cells, it was not known whether mammalian viruses naturally e...

Used in a new way, RNA interference permanently silences key breast cancer gene

...rson Cancer Center have developed a way to use RNA interference (RNAi) so that it permanently hampers breast cancer development. The technique permanently silences activated STAT3, a crucial gene found in some human breast tumors, thus reducing the cancer's ability to become invasive. The study, presented at the...

Scientists identify genetic pathways essential to RNA interference

...ified 80 new genes essential to the process of RNA interference (RNAi), a powerful new research tool for inactivating genes in plants or animals. They used the RNAi process itself to find new genes that participate in the gene-silencing mechanism, which someday may help to fight human disease. The report will app...

Silence the gene, save the cell: RNA interference as promising therapy for ALS

...le de Lausanne (EPFL) in Switzerland have used RNA interference in transgenic mice to silence a mutated gene that ...ues targeted the cause of the disease by using RNA interference to silence the defective gene, preventing it from expressing the SOD1 protein. RNA interference is ...

Researchers rein in regulatory RNAs

...rigger posttranscriptional gene regulation via RNA interference (RNAi) by virtue of their ability to form double-stranded RNA (dsRNA) molecules. A large proportion of these antisense RNAs represent non-coding RNAs. Thus, the researchers expect that these results will lead to a better understanding of roles of no...

Researchers find new genes necessary to make embryo

...l organism to study how embryos develop. Using RNA interference (RNAi), a method for identifying the function of genes, the researchers almost double previous estimates of how many genes are required to make an embryo. Their study focused on the genes expressed by the mother and imparted to the egg, ready to be u...

Scientists identify genetic pathways essential to RNA interference

...ified 80 new genes essential to the process of RNA interference (RNAi), a powerful new research tool for inactivating genes in plants or animals. They used the RNAi process itself to find new genes that participate in the gene-silencing mechanism, which someday may help to fight human disease. The report will app...

Weill Cornell Research Reveals Secrets Of Trafficking Within Cells

.... It combined two pre-existing technologies -- RNA interference (RNAi), where scientists cut down on protein expression by jamming the responsible gene with bits of RNA; and microscopy, which looks at the activity of individual living cells by attaching a fluorescent tag to a specific cell component -- in this ca...

Novel antiviral technology inhibits RSV infection in mice

...ision ofAllergy and Immunology. "We found that RNA interference targeting avirus's NS1 gene can be administered in the form of a nasal drop orspray. The treatment keeps the host's natural antiviral shield intactand attenuates virus reproduction, providing substantial protectionfrom severe infections over days to ...

1 2 3