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Tag: "interference" at biology news

Researchers shed light on mechanism of action used by anti-cancer drug

...onsequence of Raf inhibition, but rather reflected interference with the synthesis of Mcl-1. They found that sorafenib interfered with Mcl-1 translation, a process in which proteins are synthesized from their constituent amino acids. However, the mechanism by which protein translation was inhibited by sorafenib r...

Blood-brain barrier breached by new therapeutic strategy

...n. Furthermore, repeated administration of the RNA interference therapy did not trigger inflammation or antibodies to the peptide. Currently, doctors use various methods to deliver therapeutic drugs directly into the brain. These methods involve invasive procedures that result in only localized delivery aroun...

Scientists discover rare 'gene-for-gene' interaction that helps bacteria kill their host

...t. The researchers then used a technique known RNA interference to prevent the insects from producing the phenoloxidase enzyme. These insects were more susceptible to regular Photorhabdus bacteria. But when the two were combined, it was found that not being able to produce ST made no difference to Photorhabdus...

RNA splicing factor implicated in ovarian tumor cell growth

...edge, this is the first time anyone has shown that interference with the production of a splicing factor can inhibit tumor cell growth and tumor invasiveness," Beck said. "Alternatively-spliced genes and splicing factors are likely to play a key role as therapeutic targets and diagnostic markers in the next decad...

Inflammation may play role in metastasis of prostate cancer

...h RANK ligand production or activation, as well as interference with IKKa activation, may offer new therapeutic strategies for prevention of metastatic disease....

Molecular signature may identify cisplatin-sensitive breast tumors

...en in other types of breast cancers. Using an RNA interference system to inhibit the action of p63, they showed that the protein stimulates tumor growth by interfering with p73’s normal ability to induce cell death. Cisplatin was found to break up the binding of p63 to p73 and reactivate the cell-death process. ...

New sensor detects gaseous chemical weapon surrogates in 45 seconds

...angement was cumbersome, power-hungry and prone to interference from external sound and vibration. In the QPAS technique, several QCLs can fit on a 3 x 3 millimeter chip. And the tuning forks are identical to the kind used in wristwatches, measuring only 4 millimeters long, 2 millimeters wide and 0.3 millimete...

RNAi shows promise in gene therapy, Stanford researcher says

...s showing that a biological phenomenon called RNA interference could be an effective gene therapy technique. Since then he has used RNAi gene therapy to effectively shut down the viruses that cause hepatitis and HIV in mice. With three human RNAi gene therapy trials now under way - two in macular degeneratio...

Neural bottleneck found that thwarts multi-tasking

...esponses were enlisted in order to ensure that any interference between the two tasks was not specific to a partic... "This temporal delay is the essence of dual-task interference for tasks that require actions. By using time-resolved fMRI, we can see its signature in the brain,"...

Study of planarians offers insight into germ cell development

...narians. Blocking nanos expression by means of RNA interference immediately after the planarians hatched prevented the emergence and development of germ cells. Blocking nanos in mature adults caused their ovaries and testes to disappear. And when the researchers blocked nanos expression in planarians that had had...

Nanoparticles can track cells deep within living organisms

...rferes with medical imaging. Moreover, the lack of interference means we can measure very low amounts of the labeled cells and closely estimate their number by the brightness of the image." The researchers believe that nanoparticle-labeled adult stem cells could be used to evaluate tumors. Under an MRI scan, ...

Turning a cellular sentinel into a cancer killer

...e. They suppressed p53 protein levels by using RNA interference (RNAi) that had been modified so that RNAi could be switched off by the antibiotic. The RNA interference technology was developed in collaboration with HHMI investigator Gregory Hannon at Cold Spring Harbo...

Novel laboratory technique nudges genes into activity

...o intercept and bind with messenger RNA. While RNA interference is an effective tool for studying gene expression, Dr. Janowski said, it’s more efficient to use RNA to control both activation and de-activation at the level of the chromosome. "It goes right to the source, right to the faucet to turn the genes ...

New research shows why too much memory may be a bad thing

...own. Because working memory is highly sensitive to interference from information previously stored in memory, forgetting such information may therefore be necessary for performing everyday working memory tasks, such as balancing your check book or decision making. "We were surprised to find that halting neurog...

Cocaine high caused by interference in neuronal receiving stations

...eceptor for glutamate. The result, they found, was interference with normal activation of this glutamate receptor. John Wang, of the University of Missouri, Kansas City School of Medicine, and his colleagues published their findings in the December 7, 2006, issue of the journal Neuron, published by Cell Press. ...

Sensory feedback during speech: The brain attunes to more than just sound

...h sounded normal, and it occurred when the robotic interference was applied during both vowel and consonant sound production. The findings support the idea that accurate acoustic quality is not the brain's only goal during the motor control of speech--precision in expected somatosensory feedback cues is also a...

American scientist's research of life's first cells

...cal School in Worcester, she characterized the RNA interference (RNAi) pathway in Drosophila and humans, and the therapeutic application of RNAi to diseases such as Amyotrophic lateral sclerosis (ALS). Schwarz' thesis work was recognized with a 2005 Harold M. Weintraub Graduate Student Award. She is currently...

Regulating the nuclear architecture of the cell

...eus. Mutations in another pathway, that of RNA interference (RNAi), produced related results. One way RNAi wor...r the HP1 protein; or a mutation that disables RNA interference -- allows the heterochromatin to open up. The decondensed, repeated DNAs are then free to interact; ...

A new understanding of how cells defend themselves against bacterial pore-forming toxins

... The Swiss team studied the pathway by using RNA interference to silence genes involved. Interrupting the pathway at any point, either by silencing the genes responsible for the inflammasome formation or the gene for caspase-1, resulted in increased cell death. "We don't yet know the details of the mechanism...

UGA scientists engineer root-knot nematode resistance

...n crops, Huang said. "Our results of in-plant RNA interference silencing of a parasitism gene in root-knot nematodes provides a way to develop crops with broad resistance to this destructive pathogen," Hussey said. "Equally important, our approach makes available a strategy for developing root-knot-nematode-resi...

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