It's in the genes: Study opens door to new treatment of the blues
...ated mice also displayed little interest in sexual interaction and showed decreased preference for palatable sugary drinks over plain water. A month later, the rodents' interest in sex and sweets had returned, but the social avoidance remained. The researchers found that long-term use of antidepressants, such a...Two NIH initiatives launch intensive efforts to find roots of common diseases
...his exciting initiative immediately. Moreover, the interaction of scientists from the public and the private sect...sition actually makes a person sick depends on the interaction between genes and the environment. We need better tools to evaluate environmental exposures, dietary...Macrophage signaling may affect hormone resistance in prostate tumors
...etermine whether a macrophage/prostate cancer cell interaction occurs, if it is a common event in prostate cancer...rch shows at a mechanistic level that the physical interaction of macrophages with prostate tumor cells activates processes in both cell types that cause the activ...Unraveling the mysteries of poison
...ally flexible the binding partner is; for a strong interaction to take place, the molecules of both partners have to be able to change their structures. Applying these new spectroscopic methods, scientists are now better understanding the pharmacology and physiology of potassium channels. This could lead to bet...Novel method reveals how menthol discovery could point towards new or improved pain therapies
.... The scientists' analysis pinpointed a potential interaction site for menthol, as well as a site that translate...imulus-response pathways) that are involved in the interaction with small molecules that affect their function. ...New insight into machinery of immune cells' 'tentacles'
... The researchers sought to understand whether the interaction between Abi and a complex of proteins that include the Wave family of proteins, might regulate actin polymerization. The Abi/Wave complex had already been shown to be involved in actin polymerization in other cells, said Pendergast. Using tracer mo......essential for its ability to cause disease and its interaction with our immune system and some serotypes are more likely to be associated with disease." "The current vaccines provide excellent protection against pneumococcal disease, but only that caused by some of the 90 serotypes, and it is important that we...Tumor cells that border normal tissue are told to leave
...imity of the boundary cells to normal cells--their interaction with normal cells--made them special," Vidal says. "This is the first time the epithelial environment has been shown to play a role in metastasis." The cells that left the fruit fly tumors eventually succumbed to the natural process of programmed ce...Higher carbon dioxide, lack of nitrogen limit plant growth
...ide hinges on an ability to understand the complex interaction between atmospheric carbon dioxide and nitrogen in soils, the scientists believe. The six-year study, the longest of its kind, sheds light on the relationship between carbon dioxide emissions and plant productivity. In the experiment, scientists gre...Scientists force viruses to evolve as better delivery vehicles for gene therapy
... of which were responsible for most of the altered interaction with antibodies. "Starting from scratch, just trying to rationally decide which two amino acid changes to make on the virus, there is no way you would have guessed those two," Schaffer said. "Using the same algorithm as nature came up with - evoluti...Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons
...ed in the April issue of Cancer Cell, examines the interaction between tumor cells and surrounding tissues and ma...tend beyond the tumor itself and involve a complex interaction between the cancer cells and the normal cells that are perturbed by expanding tumor. These results ...Legume compounds may help cancer treatment
...entified several compounds derived from the legume interaction with rhizobium bacteria that show strong anti-angiogenic activity. "They are promising therapeutic molecules which clearly warrant further investigation," Professor Parish said. CILR Director Professor Peter Gresshoff said the current research succ...Molecular force field helps cancer cells defend against attack
...Cance said. "We've shown that if you disrupt this interaction - if you block the binding of these two proteins -...killed," he said. UF researchers identified FAK's interaction with VEGFR-3 in cell cultures of human breast cancer. Breast cancers that pump out high volumes of F...Man's best friend: Study shows lonely seniors prefer playtime with pooch over human interaction
...e dog acts as a social lubricant and increases the interaction between the residents. We expected the group dog visits were going to work better, but they didn't. "The residents found a little quiet time with the pooch is a lot nicer than spending time with a dog and other people," he said. Thirty-seven nursi...FDA approves first medical device using rutgers biomaterial
...an example of a close and strong academic-industry interaction that led to a relatively fast entrance of the product into the medical market." Kohn pointed out that the technology was invented in 1997 and has progressed along a fast and efficient track to FDA approval ?a process that usually takes 10 years or m...Enzyme crystal structure reveals 'unexpected' genome repair functions
...ot act directly in initial damage recognition, the interaction of XPB with the DNA lesion suggests that XPB plays a role in switching TFIIH from transcription mode to NER," Tainer says. "The structural biochemistry of XPB that we discovered shows an unexpected molecular mechanism by which XPB plays a key role in...First direct mechanical communication of mitochondria, cardiomyocyte nucleus shown
...as been interested for many years in mechanisms of interaction between mitochondria and other organelles. They use "skinned cardiac fibers" whose outer membranes have been chemically removed which allows them to control the intracellular medium. They believed that in the tightly packed myocyte, that "mitochondri...APS lecturer shows rare video of 'teacher-student' immune cell interactions in live animal
...assing the information on to their successors. The interaction between T cells and dendritic cells in the lymph node changes over time, von Andrian said. "It's nice that the T cell learns to recognize the antigen, but that doesn't get rid of the microbe that has entered the body," von Andrian said. He traced th...New McGill research shows mice capable of empathy
...tanding pain in humans. "Since we know that social interaction plays an important role in chronic pain behaviour in humans," Dr. Mogil said, "then the mechanism underlying such effects can now be elucidated; why are we so affected by those around us?" Dr. Mogil, the E.P. Taylor Professor of Pain Studies at McG......ically interacts with FRQ; the mutation makes this interaction much stronger. However, a mutant enzyme that has lost its activity has no effect on the clock. Normally CHK2 is involved in the signal response pathway that begins when DNA is damaged and results in a temporary stoppage of cell division until the da...