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Tag: "interaction" at biology news

Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants

...rovides valuable understanding of the mechanism of interaction betweenthe pollen tube and female tissue during reproduction.“Integrating materials science, chemistry and plant biology tounderstand how and where specific proteins act on a pollen tube is onemore step towards a better understanding of the fundament...

Research advances quest for HIV-1 vaccine

...formed when 4E10 binds to gp41 and determining how interaction of 4E10 with gp41 influences the virus. X-ray crystallography was used to determine the structure of the complex formed by association of 4E10 with a peptide fragment that is identical to the section of gp41 that the antibody recognizes. The researc...

The secret to longevity in tubeworms

...n. By providing a model in which this hypothetical interaction provides real benefits and explains real observations, the authors hope to stimulate further research into the biology of the enigmatic and beautiful L. luymesi. ### Citation: Cordes EE, Arthur MA, Shea K, Arvidson RS, Fisher CR (2005) Modeling the...

Bound for destruction: Ubiquitination protects against improper Notch signaling

...e clearerwhen the group next turned to examine the interaction between Nedd4 andDeltex (Dx), a putative ubiquitin ligase known to bind and activate theNotch receptor. Hayashi’s group found evidence that Nedd4 and Dx viewith each other to regulate Notch activity during endocytosis, and thatNedd4 actually destabil...

Spider Venom Could Yield Eco-Friendly Insecticides

...f the regions of the toxins that are essential for interaction with insect ion channels. (Ion channels allow the movement of ions -- small charged molecules -- across cell membranes.) His next challenge is to use this information to design insecticides that specifically target insect pests without affecting ver...

Vital step in cellular migration described by UCSD medical researchers

...April print edition, the study describes how a the interaction of alpha4 integrin adhesion receptor with a protein called paxillin creates directional movement of a cell by inhibiting a protein called Rac. "Understanding how this protein contributes to directional movement of a cell provides a new insight into ...

Open microfluidic and nanofluidic systems

...e channel depth to the channel width; and (ii) the interaction between substrate material and liquid. One has to distinguish seven different liquid morphologies which involve localized droplets (D), extended filaments (F), and thin wedges (W) at the channel corners. For microfluidics applications, the most impor...

Agilent Technologies releases automated literature search tool for biology researchers

...matics software platform for visualizing molecular interaction networks and integrating these interactions with gene expression profiles and other data. The platform supports gene functional annotations from Gene Ontology (GO) and KEGG databases, biological models from Systems Biology Markup Language (SBML), pro...

RNA project to create language for scientists worldwide

...Networks, whose goals are to "encourage and foster interaction among scientists" and to facilitate "innovative ideas for implementing novel networking strategies." As principal investigator, Leontis will serve as coordinator of the consortium, which includes scientists from the United States, Great Britain, Fra...

Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits

...etely disable target proteins. Ideker said protein interaction information could help modify that approach to drug discovery. "Maybe the target protein has a good and necessary role in 10 interactions, but the 11th is the only one we would need to eliminate," said Ideker. "What we really want are drugs that inte...

Unexpressed But Indispensable -- The DNA Sequences That Control Development

...njected had upregulated GFP expression, indicating interaction of these sequences with endogenous transcription factors. Different CNEs caused different regional patterns of expression, in keeping with their presumed roles in distinct developmental processes. The discovery of these developmentally important seq...

VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain

...of nervous system development. "We found that the interaction between the Bdnf gene and several other genes that interact with Bdnf were all regulated in one region of the brain that is known to play a role in drug addiction," Miles said. "These findings suggest a 'network' of genes that may be a key to underst...

Sequencing of marine bacterium will help study of cell communication

...biology at Virginia Tech, studies how cell-to-cell interaction regulates bacterial processes that include antibiotic or toxin production, biofilm formation, and bioluminescence. One of the longest studied models of quorum sensing is the bioluminescent marine bacterium V. fischeri. "It was selected by Drs. Ruby ...

Multiple Campylobacter Genomes Sequenced

... synthesis of molecules that are important for the interaction of Campylobacter with the environment. Such differences could underlie the host specificity of the different species. Differences between the Campylobacter species in genes that are likely to be involved in aspects of bacterial virulence, such as ad...

Epstein-Barr virus protein crucial to its role in blood cancers

...B-cell lymphoma. The use of peptides to block the interaction between this essential EBV protein and the specific pathway in human B cells is currently underway. Initial studies show that the growth of EBV-associated cancer cells can be inhibited in tissue-culture assays. The investigators are actively pursuing...

Defensins neutralize anthrax toxin

...B-cell lymphoma. The use of peptides to block the interaction between this essential EBV protein and the specific pathway in human B cells is currently underway. Initial studies show that the growth of EBV-associated cancer cells can be inhibited in tissue-culture assays. The investigators are actively pursuing...

Computational Method Speeds Mapping of Cell Signaling Networks

...o identified a previously unknown T-cell signaling interaction that connects two pathways. Prediction is the great strength of Bayesian network analysis--particularly in the post-genomic age when researchers are generating vast amounts of data. The statistical approach requires no prior knowledge of signaling p...

Navigating an integrated yeast network

...enhancing our understanding of how the networks of interaction by which components of a cell influence one anothe...tic maps of an integrated Saccharomyces cerevisiae interaction network Lan V Zhang, Oliver D King, Sharyl L Wong, Debra S Goldberg, Amy HY Tong, Guillaume Lesage, ...

Harmful chemicals may reprogram gene response to estrogen

... "We are looking at a new kind of gene-environment interaction that determines who gets cancer and who doesn't." According to Walker, the increase in frequency and size of the uterine tumors is due to DES' ability to influence estrogen, a female hormone that is involved in promoting the growth of tumors by regu...

Potential Drug Target For Treating Cocaine Abuse Found

...ew study shows this may not be true. "In fact, the interaction between dopamine trans-porters and the substances that bind to them may depend on the chemical structure of those substances," says NIDA's Amy Newman, who synthesized the compound. The researchers found that their novel drug made contact with transpo...

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