Sudden change in social status triggers genetic response in male fish, study finds
...Our study shows that the male cichlid is obviously interacting with the world around it," says Burmeister, a former postdoctoral fellow in the Fernald lab, now assistant professor of biology at the University of North Carolina-Chapel Hill. "The subordinate male is responding to the absence of another individual,...UCLA researchers identify key enzyme linked to childhood blindness
...osely with Rpe65. Mutations in the genes for these interacting proteins are linked to other forms of human blindness. "These results settle the long standing mystery about the identity of the retinoid isomerase," Travis said. "Scientists have been searching for this enzyme for almost 20 years. Our results also ...Primate virus jumps species barrier to humans for first time in Asia
...hey do urge people to be cautious and careful when interacting with monkeys. Feeding the animals, or even carrying food into a temple, can greatly increase the risk of a bite or scratch, which can lead to transmission of infection. Visitors occasionally engage in other risky behavior, such as touching animals or...Scientists show that tick-borne flaviviruses use a novel mechanism to evade host defenses
...signaling pathway, and then identifies some of the interacting partners in the cell and virus." Prior to this work, Dr. Bloom says, scientists knew only that NS5 helped tick-borne flaviviruses replicate. RML's Sonja Best, Ph.D., who spearheaded the Langat virus work, says the group will continue to study tick-b...Spiders help scientists discover how muscles relax
...e heads of each myosin molecule are inhibited from interacting with actin by interacting with each other instead. When muscle is activated, they suggest, the bonds between the myosin heads ...Researchers seek to discover what really happens when a virus enters the body
...ty signals (IIS) depict how the virus and host are interacting over time, from the point of origin to the point of infection," Bell says. Ultimately, the interdisciplinary team hopes their efforts will provide a quantitative method that derives a characteristic profile or fingerprint from the IIS of any host-v...UCR chemist part of team identifying new areas of gene regulation
...orting structures housing the cell's DNA. Histones interacting with each other form a 'spool' around which DNA is wrapped in the cell. Grunstein, one of the scientists in the current team, discovered in 1991 that sites of histone acetylation, a modification of the protein, play a fundamental role in the regulati...Study finds adult stem cells can replicate
...mine what molecules cathepsin G is sticking to and interacting with on the surfaces of neutrophils and other cells. ### Raptis SZ, Shapiro SD, Simmons PM, Cheng AM, Pham CTN. Serine protease Cathepsin G regulates adhesion-dependent neutrophil effector functions by modulation integrin clustering. Immunity, June...Enzyme's newly discovered role may make it target for arthritis treatment
...mine what molecules cathepsin G is sticking to and interacting with on the surfaces of neutrophils and other cells. ### Raptis SZ, Shapiro SD, Simmons PM, Cheng AM, Pham CTN. Serine protease Cathepsin G regulates adhesion-dependent neutrophil effector functions by modulation integrin clustering. Immunity, June...Random gene expression may drive HIV into hiding
... Commonly, it's only when just a few molecules are interacting with each other that random fluctuations can have such a large effect on eventual outcome, he explained. The researchers hope that understanding the molecular basis of HIV latency will lead to new treatments to slow or stop progression to AIDS. For ...Critical step traced in anthrax infection
...channel. The clamp appears to work as a chaperone, interacting with the hydrophobic sequences on the two factors as they unfold during translocation. The researchers demonstrated that the phi-clamp was critical to infection by mutating the region and thereby blocking translocation of the toxin proteins. These r...Cancer related gene p53 not regulated as indicated by previous tissue culture research
...irst author Kurt Krummel. "You have to look at all interacting partners because after all, modifications of p53 itself might not be so important as modifications of negative regulators and co-activators." Many chemotherapeutical drugs used to treat cancer exert their biological effects on tumor cells through ac...New miniaturised chip dramatically reduces time taken for DNA analysis
...sors. These can identify a substance by chemically interacting with it and converting this interaction into an electrical current that they measure. To detect DNA, the new miniaturised electrochemical genosensors have a probe containing DNA fragments that complement the DNA they aim to detect. For example, to d...Evidence of 600-million-year old fungi-algae symbiosis discovered in marine fossils
...inds of organisms living together and, we believe, interacting in more than a chance association." In modern lichens and in the 400-million-year-old Scotland fossils, the coccoidal cells provide the nutrients and the fungal filaments provide protection against dehydration. But in the marine environment, dehydra...Scripps scientists find potential for catastrophic shifts in Pacific ecosystems
...any disciplines involving complex webs of mutually interacting parts, such as ecosystems and world financial markets, which have the potential for unexpected collapse and irreversible change. Scripps Professor George Sugihara and Scripps students Chih-hao Hsieh, Sarah Glaser and Andrew Lucas conducted the study...New polysaccharide may help combat multidrug resistance in cancer
...ecules that bind to hyaluronan and prevent it from interacting with CD44 were able to sensitize multidrug resistant breast cancer cells to chemotherapeutic drugs. The researchers also found that increasing hyaluronan synthesis in cells increased resistance to drug treatment. "Our work indicates that hyaluronan ...Shutting down the HIV assembly line
... partners. They identified several known and novel interacting proteins and selected one, the delta subunit of AP-3, for further evaluation. AP-3 is an "adaptor protein complex," a group of four proteins known to sort cargo proteins to specific compartments in the cell. Through a series of experiments, the grou...How the environment could be damaging men's reproductive health
...DS is caused by environmental conditions, possibly interacting with genetic factors, the question arises as to whether adverse changes in the environmental factors affecting male reproductive health have taken place in Lithuania in the last 20 years. "We need to look more closely at the role of environmental fa......uman body functions as a carefully woven fabric of interacting species. Ultimately, such understanding promises to provide new ways of fortifying health and preventing or treating a variety of diseases both inside and outside of the gastrointestinal tract." ...