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Tag: "integrin" at biology news

Vital step in cellular migration described by UCSD medical researchers

...he study describes how a the interaction of alpha4 integrin adhesion receptor with a protein called paxillin c...al cells, the UCSD team discovered that the alpha4 integrin recruits enzymes that block Rac activity only at the rear of a crawling cell. The scientists noted ...

Enzyme's newly discovered role may make it target for arthritis treatment

..." Pham explains. "The proteases' ability to affect integrin rearrangement is dependent on their catalytic acti...endent neutrophil effector functions by modulation integrin clustering. Immunity, June 7, 2005, 679-691. Funding from the Arthritis Foundation and the National ...

Study finds adult stem cells can replicate

..." Pham explains. "The proteases' ability to affect integrin rearrangement is dependent on their catalytic acti...endent neutrophil effector functions by modulation integrin clustering. Immunity, June 7, 2005, 679-691. Funding from the Arthritis Foundation and the National ...

Unexpected lock and key mechanism found for the assembly of tumor blood vessels

...s cell. Varner and her team found that a specific integrin protein called alpha4beta1 was produced at high le...ssel, the interior area called the endothelia. The integrin was not produced in mature blood vessels, indicating a specific role in developing vessels. The team...

The making of a fat cell

...including a critical switch in gene activity--from integrin alpha 5 to integrin alpha 6. That switch allows preadipocytes to cease dividing and cluster, forming bona fide fat cells...

System Drastically Cuts Down Botulism Detection Time

...including a critical switch in gene activity--from integrin alpha 5 to integrin alpha 6. That switch allows preadipocytes to cease dividing and cluster, forming bona fide fat cells...

Short-term Bio Sensors Monitor From Afar

...including a critical switch in gene activity--from integrin alpha 5 to integrin alpha 6. That switch allows preadipocytes to cease dividing and cluster, forming bona fide fat cells...

Key To Stem Cell Transplant Success Is Tricking Immune System

...including a critical switch in gene activity--from integrin alpha 5 to integrin alpha 6. That switch allows preadipocytes to cease dividing and cluster, forming bona fide fat cells...

Researchers unveil strategy for creating actively-programmed anti-cancer molecules

...nt enhancement in the therapeutic efficacy" of the integrin antagonist directly attributable to the chemically programmed antibody approach. Moreover, the study indicated that this approach allows for the effective assembly of chemically programmed antibodies in vivo or in vitro, widening the possibilities...

UCSD researchers create roadmap to integrin activation

... of the body's most abundant platelet receptor, an integrin called glycoprotein (GP) IIb-IIIa, provides a powe...e the platelet to the outside tells the GPIIb-IIIa integrin on the cell's surface to get sticky. Direct inhibitors of GPIIb-IIIa binding include antithrombot...

Targeting tumors the natural way

...s group modified an agent known to bind tightly to integrin and tethered it to alpha-Gal. When they mixed this...tead: They were killed regardless of the amount of integrin they carried. Because target receptors on cancer cells usually reside on healthy cells, too - albe...

Researcher to study astronaut bone loss for space biology agency

...is is that during prolonged weightlessness, beta-3 integrin production decreases, which in turn diminishes the...ng exercise while in orbit –?in order to stimulate integrin production and enhance or recover IGF-1 receptor function. The IGF-1 will act as a signaling device ...

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